MC21/CTF and VERA multiphysics solutions to VERA core physics benchmark progression problems 6 and 7

Daniel J. Kelly III,Ann E. Kelly,Brian N. Aviles,Andrew T. Godfrey,Robert K. Salko,Benjamin S. Collins 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.6

The continuous energy Monte Carlo neutron transport code, MC21, was coupled to the CTF subchannelthermal-hydraulics code using a combination of Consortium for Advanced Simulation of Light WaterReactors (CASL) tools and in-house Python scripts. An MC21/CTF solution for VERA Core PhysicsBenchmark Progression Problem 6 demonstrated good agreement with MC21/COBRA-IE and VERA solutions. The MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 7, Watts Bar Unit1 at beginning of cycle hot full power equilibrium xenon conditions, is the first published coupled MonteCarlo neutronics/subchannel T-H solution for this problem. MC21/CTF predicted a critical boron concentrationof 854.5 ppm, yielding a critical eigenvalue of 0.99994 ± 6.8E-6 (95% confidence interval). Excellent agreement with a VERA solution of Problem 7 was also demonstrated for integral and localpower and temperature parameters.

Calcium Antagonists in Angina Pectoris

Kelly, David T. Medical Publications Korea 1986 Medical Progress Vol.8 No.12

Optimum Use of Calcium Antagonists in Angina Pectoris

Kelly, David T. Medical Publications Korea 1985 Medical Progress Vol.7 No.7

<i>Phellinus linteus</i> activates different pathways to induce apoptosis in prostate cancer cells

Zhu, T,Guo, J,Collins, L,Kelly, J,Xiao, Z J,Kim, S-H,Chen, C-Y Nature Publishing Group 2007 The British journal of cancer Vol.96 No.4

<P>It is known that polysaccharides extracted from the <I>Phellinus linteus</I> (PL) mushroom possess antitumour activity. We previously have demonstrated that high doses of PL render murine or human lung cancer cells susceptible to apoptosis. However, the molecular mechanisms of PL-mediated apoptosis have not been fully explored. In this study, we demonstrate that LNCaP cells expressing the androgen receptor (AR) are highly susceptible to apoptosis in response to treatment with high doses of PL. In this process, caspase 8 and its downstream effectors (such as BID), as well as ER stress-related, apoptotic signalling, are activated. In contrast, a moderate amount of apoptosis occurs in PC3 cells (that lack AR) after the same treatment, which does not activate ER-mediated apoptotic signalling. We also show that, in the process of PL-induced apoptosis, caspase 2 is induced in LNCaP cells, but not in PC3 cells. However, LNCaP cells that express a mutated AR or LNCaP cells treated with a caspase 2 inhibitor blocked ER stress-induced apoptotic signals. The magnitudes of the induction of apoptosis in these cells are comparable with what occurred in the PC3 cells. The data demonstrate that high doses of PL activate the AR-dependent and independent apoptotic pathways. Our study also suggests that caspase 2 is a key target in the determination of the susceptibility of prostate cancer cells to PL-induced apoptosis.</P>

Effect of PCBN tool grade on joint strength and tool life in friction stir spot welded DP 980 steel

Hartman, T.,Miles, M.P.,Hong, S.-T.,Steel, R.,Kelly, S. Elsevier 2015 Wear: An international journal on the science and Vol.328 No.-

<P><B>Abstract</B></P> <P>Friction stir spot welding of advanced high strength steel, like dual phase (DP) 980, is a very demanding application in terms of tool wear. The best candidate material currently being tested is polycrystalline cubic boron nitride (PCBN). The purpose of the current work is to study the effect of PCBN material grade, as specified primarily by CBN grain size, on weld quality and tool life, for the spot welding of DP 980 steel. With a nominal composition of 90% CBN, three tool grades were tested. Grade A had CBN grain sizes of 3–6μm, grade B had grain sizes of 12–15μm, and grade C had a multimodal distribution, with grain sizes ranging from 4 to 40μm. The best performance in terms of joint strength and tool life was achieved with grade A. The effect of fine CBN grain size was less adhesion of DP 980 on the tool surface over time, less abrasive wear, and higher lap shear failure loads of the welds that were produced, compared to the other grades. A-type tools were the most consistent in both the number of welds per tool, and the number of welds that reached acceptable lap shear failure loads. B-type tools, performed slightly better than C-type tools in terms of wear, but neither of them was able to achieve consistent, acceptable lap shear failure load values after the first 200 welds. In fact only one out of five C-type tools was able to produce acceptable lap shear failure loads after the first 100 welds. Based on the experimental evidence, tool wear was likely dominated by grain pullout. This is consistent with the correlation showing that larger CBN grain size was related to shorter tool life.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We monitored wear resistance of PCBN tools over thousands of friction stir spot welds in DP 980 steel. </LI> <LI> CBN grain size was found to have a significant impact on tool life and on joint strength. </LI> <LI> Grain pullout was postulated to be the primary wear mechanism based on the evidence. </LI> </UL> </P>

Femtosecond X-ray Absorption Spectroscopy at a Hard X-ray Free Electron Laser: Application to Spin Crossover Dynamics

Lemke, Henrik T.,Bressler, Christian,Chen, Lin X.,Fritz, David M.,Gaffney, Kelly J.,Galler, Andreas,Gawelda, Wojciech,Haldrup, Kristoffer,Hartsock, Robert W.,Ihee, Hyotcherl,Kim, Jeongho,Kim, Kyung Hw American Chemical Society 2013 The journal of physical chemistry. A, Molecules, s Vol.117 No.4

<P>X-ray free electron lasers (XFELs) deliver short (<100 fs) and intense (∼10<SUP>12</SUP> photons) pulses of hard X-rays, making them excellent sources for time-resolved studies. Here we show that, despite the inherent instabilities of current (SASE based) XFELs, they can be used for measuring high-quality X-ray absorption data and we report femtosecond time-resolved X-ray absorption near-edge spectroscopy (XANES) measurements of a spin-crossover system, iron(II) tris(2,2′-bipyridine) in water. The data indicate that the low-spin to high-spin transition can be modeled by single-exponential kinetics convoluted with the overall time resolution. The resulting time constant is ∼160 fs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcafh/2013/jpcafh.2013.117.issue-4/jp312559h/production/images/medium/jp-2012-12559h_0008.gif'></P>

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

Harley, Isaac T. W.,Niewold, Timothy B.,Stormont, Rebecca M.,Kaufman, Kenneth M.,Glenn, Stuart B.,Franek, Beverly S.,Kelly, Jennifer A.,Kilpatrick, Jeffrey R.,Hutchings, David,Divers, Jasmin,Bruner, G Hindawi Publishing Corporation 2010 Journal of biomedicine & biotechnology Vol.2010 No.-

<P>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. IFN-kappa is a type I IFN expressed in skin. A pooled genome-wide scan implicated the <I>IFNK</I> locus in SLE susceptibility. We studied <I>IFNK</I> single nucleotide polymorphisms (SNPs) in 3982 SLE cases and 4275 controls, composed of European (EA), African-American (AA), and Asian ancestry. rs12553951C was associated with SLE in EA males (odds ratio = 1.93, <I>P</I> = 2.5 × 10<SUP>−4</SUP>), but not females. Suggestive associations with skin phenotypes in EA and AA females were found, and these were also sex-specific. <I>IFNK</I> SNPs were associated with increased serum type I IFN in EA and AA SLE patients. Our data suggest a sex-dependent association between <I>IFNK</I> SNPs and SLE and skin phenotypes. The serum IFN association suggests that <I>IFNK</I> variants could influence type I IFN producing plasmacytoid dendritic cells in affected skin.</P>

Pathogenesis of Hantaan Virus Infection in Sucking Mice

Gum Ryong Kim,Kelly T . Mckee,Ho Wang Lee 대한바이러스학회 1986 Journal of Bacteriology and Virology Vol.16 No.1

Pathogenesis of Hantaan Virus Infection in Suckling Mice Clinical , Virologic and Serologic Observations

Lee, Ho Wang,Kim, Gum Ryong,Kelly T . Mckee 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1

Hemorrhagic fever with renal syndrome (H FRS) is a debilitating disease of humans cau- sed by Hantaan virus (HVI, the prototype member of a newly proposed genus of Bunyaz:Iridae. Studies of HV pathogenesis have been limited by the absence of a well defined model for a virus-induced disease state. In an at- tempt to devise a model for HV pathogenesis in laboratory rodents, newborn outbred suckling ICR mice were shown to be uniformly susceptible to lethal infection with nonmouse adapted HV by intracerebral (IC), intraperitoneal (IP), intramuscular (IM), and subcutaneous (SC) inoculation routes. Clinical coures, mean time to death, and fatal outcome were age-dependent. With an inoculum of 10 LD, mortality was 100% in mice infected within 72h of birth, but declined to 50% by 7 days. By 2-2.5 weeks, animals developed complete resistance to clinical disease. Virus was consistently deteeted in serum by day 6 post-in- fection in IC:- and IP- inoculated animals, and reached peak levels of 10' PFU/ml byday 8; Mice infected IM and SC showed delays in onset of viremia, but achieved similar titers. Immunofluorescent antibody appeared by 17-18 days, and neutralizing antibody by 15 days, in all experimental groups. Two of 8 inbred mouse strains were identified as resistant to clinical disease: SJL/J and A/J. Manipulation of this model will allow investigation of natural rodent pathogenesis with HV, as well as offer insight into disease mechanisms and therapy of HFRS.

Design approach of high damping rubber bearing for seismic isolation

Patrick L.Y. Tiong,James M. Kelly,Tan T. Or 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.20 No.3

Structural control through seismic isolation using elastomeric rubber bearing, which is also known as High Damping Rubber Bearing (HDRB), has seen an increase in use to provide protective from earthquake, especially for new buildings in earthquake zones. Besides, HDRB has also been used in structural rehabilitation of older yet significant buildings, such as museums and palaces. However, the present design approach applied in normal practice has often resulted in dissimilar HDRB dimension requirement between structural designers and bearing manufacturers mainly due to ineffective communication. Therefore, in order to ease the design process, most HDRB manufacturers have come up with catalogs that list all necessary and relevant product lines specifically for structural engineers to choose from. In fact, these catalogs contain physical dimension, compression property, shear characteristic, and most importantly, the total rubber thickness. Nonetheless, other complicated issues, such as the relationship between target isolation period and displacement demand (which determines the total rubber thickness), are omitted due to cul-de-sac fixing of these values in the catalogs. As such, this paper presents a formula, which is derived and extended from the present design approach, in order to offer a simple guideline for engineers to estimate the required HDRB size. This improved design formula successfully minimizes the discrepancies stumbled upon among structural designers, builders, and rubber bearing manufacturers in terms of variation order issue at the designing stage because manufacturer of isolator is always the last to be appointed in most projects.