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Localization of transient events in dispersive medium by attack time and filter bank analysis
Filip FRANEK(플필립),JunGu KANG(강준구),SungUk CHOI(최성욱),JongHo LEE(이종호) 한국소음진동공학회 2015 한국소음진동공학회 학술대회논문집 Vol.2015 No.4
Localization of vibration events in structural systems is a challenge due to character of propagating waves in dispersive medium, in which bending waves propagate with a frequency dependent speed of sound. This property of solid materials is adverse for time of arrival methods used in non-dispersive medium. The proposed ideas tackle the problem of various propagation speed of each frequency component. The first method using attack time and magnitude information detects the change of envelope that is position dependent and becomes flatter and longer further from the origin of vibration. This envelope shape can be extracted by signal manipulation that obtains positive and smoothed magnitude envelope of the original signal or it can accumulate the signal from which the slope information can be obtained, and signals can be ranked. Second method utilize standard techniques for time estimation as triggering, and cross-correlation, but it separates the signals into multiple frequency bands beforehand as was suggested by White. The results give more detailed information about closeness of sound sources since there is not only a simple integer order to indicate the closeness of sensors from the vibration origin, whereas a histogram of each method is obtained by feeding the methods through the filter banks.
Ksenija Durgo,Ana Belscak-Cvitanovic,Angela Stancic,Jasna Franekic,Drazˇenka Komes 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
In this article, the bioactive potential of red raspberry leaves, a by-product of this widely spread plant, mostly valued for its antioxidant-rich fruits, was determined. The polyphenolic profile and antioxidative properties of red raspberry leaf extract were determined and examined for potential biological activity. Cytotoxic effect, antioxidative/prooxidative effect, and effect on total glutathione concentration were determined in human laryngeal carcinoma (HEp2) and colon adenocarcinoma (SW 480) cell lines. SW 480 cells are more susceptible to raspberry leaf extract in comparison with HEp2 cells. The antioxidative nature of raspberry leaf extract was detected in HEp2 cells treated with hydrogen peroxide, as opposed to SW 480 cells, where raspberry leaf extract induced reactive oxygen species formation. Raspberry leaf extract increased total glutathione level in HEp2 cells. This effect was reinforced after 24 hours of recovery, indicating that induction was caused by products formed during cellular metabolism of compounds present in the extract. Comparison of the results obtained on these two cell lines indicates that cellular response to raspberry extract will depend on the type of the cells that are exposed to it. The results obtained confirmed the biological activity of red raspberry leaf polyphenols and showed that this traditional plant can supplement the daily intake of valuable natural antioxidants, which exhibit beneficial health effects.
The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus
Harley, Isaac T. W.,Niewold, Timothy B.,Stormont, Rebecca M.,Kaufman, Kenneth M.,Glenn, Stuart B.,Franek, Beverly S.,Kelly, Jennifer A.,Kilpatrick, Jeffrey R.,Hutchings, David,Divers, Jasmin,Bruner, G Hindawi Publishing Corporation 2010 Journal of biomedicine & biotechnology Vol.2010 No.-
<P>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. IFN-kappa is a type I IFN expressed in skin. A pooled genome-wide scan implicated the <I>IFNK</I> locus in SLE susceptibility. We studied <I>IFNK</I> single nucleotide polymorphisms (SNPs) in 3982 SLE cases and 4275 controls, composed of European (EA), African-American (AA), and Asian ancestry. rs12553951C was associated with SLE in EA males (odds ratio = 1.93, <I>P</I> = 2.5 × 10<SUP>−4</SUP>), but not females. Suggestive associations with skin phenotypes in EA and AA females were found, and these were also sex-specific. <I>IFNK</I> SNPs were associated with increased serum type I IFN in EA and AA SLE patients. Our data suggest a sex-dependent association between <I>IFNK</I> SNPs and SLE and skin phenotypes. The serum IFN association suggests that <I>IFNK</I> variants could influence type I IFN producing plasmacytoid dendritic cells in affected skin.</P>