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Indomethacin 유발 소장염증 모델에서 Fibroblast Growth Factor-10 투여에 의한 염증 조절기전에 관한 연구
한동수,Sartor, R. Balfour 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6
Background/Aims: Fibroblast growth factor-10 (FGF-10) is a homolog of keratinocyte growth factor-2 with epithelial mitogenic activity. We investigated the therapeutic role of FGF-10 in intestinal ulceration and its mechanism of protection. Methods: FGF-10 was administered before or after induction of small intestinal ulceration by indomethacin. FGF-10 was injected subcutaneously (1 or 5 mg/kg) and intravenously (1 mg/kg) daily for 6 days (acute study). Injury was evaluated by double-blinded macroscopic and microscopic scores, and the concentration of tissue interleukin (IL)-1β and the expression of collagen type I RNA were compared. It was determined whether FGF-10 has an effect on in vitro epithelial cellular proliferation, restitution of wounded monolayers, the expression of cyclooxygenase-2 (COX-2) and collagen, and regulation of NF-κB. Results: Intravenous FGF-10 significantly decreased acute intestinal injury by all parameters. FGF-10 promoted in vitro proliferation and migration of epithelial cell, anstimulated COX-2 expression, but had no effect on IκB degradation. FGF-10 affected up-regulated collagen expression in cultured myofibroblasts but not in vivo fibrosis. Conclusions: FGF-10 treats intestinal inflammation by actively promoting the mechanism to heal epithelial cells.