마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

성인용 브래지어의 치수체계에 관한 실태조사 : 케이블 TV홈쇼핑 판매제품을 중심으로 focusing on products in Cable TV Home Shopping

정화연,서미아 漢陽大學校 韓國生活科學硏究所 2003 韓國 生活 科學 硏究 Vol.- No.21

The purpose of this study is to evaluate the suitability of size of adult women's brassieres sold in Cable TV Home-Shopping. For this purpose, the characteristics of the manufacture's size chart for brassieres were analyzed and compared with Korean Industrial Standard size chart. The results of this study show that 1. The main target age of underwear brand (especially PB brand) in Cable TV Home Shopping was adult women in their middle 30's to early 40's. 2. As a consequence of reviewing the production ratio of each brassiere cup size, that of "A" and "B" cup appeared in a ratio of 7 to 3. And the highest production ratio of "A" cup size was 45% (80A), followed by 35% (75A), 15% (85A), and 5% (90A) in their order. As for B cup size, 80B was 40%, 75B was 30%, 85B was 25%, 90B was 5%. 3. Cup sizes labeled on brassieres sold in Cable TV Home-Shopping were not consistent with revised cup sizes (KS K 0070:1999) and still all brassieres were labeled by former cup sizes (KS K 0070:1987). 4. In the case of underbust circumference and bust circumference, the manufacture's size chart was not consistent with Korean Industrial Standard size chart (KS K 0070:1999). That's why Korean Industrial Standard size chart is not taken into consideration for elastic materials. 5. There is no size chart based on the characteristics of volumes and shapes of the breasts in Korean Industrial Standard size chart. Therefore, we need to set up the method of deciding the cup sizes to make up for the problem of current brassiere sizing system

목운동에 따른 상반신 체표면 변화에 관한 연구

정화연,서미아 漢陽大學校 韓國生活科學硏究所 2002 韓國 生活 科學 硏究 Vol.- No.20

The purpose of this study was to investigate the changes in upper body surface lines caused by the neck movements. Experimental research was performed by gypsum method and the neck movements were consisted of 5 types (upright posture, bending down, bending backward, leaning a head to the right side, and leaning a head to the left side). The results were as follows; 1) As a result of investigating into the rate of the expansion and contraction of horizontal body surface lines, front shoulder line was moved to be inside and back shoulder line was moved to be upside. There was a negative correlation between c3∼d1 and d1∼d2. Generally, the most of front body surface lines were contracted and back lines were mostly expanded. In particular, the rate of changes in shoulder area was higher than other areas. 2) The result of the analysis of the vertical body surface lines, the length of the center back line was increased except the movement of bending backward and the length of the renter front line was decreased in the movement of bending down. 3) According to the variation rates of the body surfaces in length of standard lines, the rate of increase of the length was higher in the front than in the back. 4) According to comparative drawing of the shape of the neck, the shape of the neck in the movement of bending backward and leaning a head to the right side was hollowed than that of the movement of upright posture. But the movement of bending down and leaning a head to the left sloe was more flat. As has been observed, upper body parts whose measurements of body surface lines were differed significantly in the neck movements. Accordingly, the task of designing garments with good neck fitness should be achieved by taking the widen amount caused by the neck movements.

천마분말이 고콜레스테롤혈증 흰쥐 혈청의 지질성분에 미치는 영향

박미연,성낙주,신정애,이수정,박필숙 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.1

This study was designed to investigate the optimum recommendation level on Gastrodia rhizoma and the effects on the improvement of the lipids in the dietary hypercholesterolemic rats. Experimental diets mixed with 5% Dioscorea batatas(Group 2), 10% Dioscorea batatas(Group 3), 15% Dioscorea batatas(Group 4), 5% Gastrodia rhizoma(Group 5), 10% Gastrodia rhizoma (Group 6) and 15% Gastrodia rhizoma(Group 7) were administered to the male rats of the Sprague Dawley for 3 weeks. Concentration of total cholesterol in serum was lower in the Gastrodia rhizoma groups than in the other groups, especially total cholesterol concentration of 10% Gastrodia rhizoma(Group 6) was the lowest in the Gastrodia rhizoma groups. Concentration of HDL-cholesterol in serum was higher in the 10% Gastrodia rhizoma and 15% Gastrodia rhizoma than in the other groups. Concentrations of cholesterylester, LDL, LDL-cholesterol in serum were the lowest in the 10% Gastrodia rhizoma. Concentration of glucose and activity of GPT in serum were the lowest in the 10% Gastrodia rhizoma group. The activity of GOT in serum was lower in the 10% Gastrodia rhizoma group and 15% Gastrodia rhizoma group than in the other groups. Therefore, we consider that there are effects on the improvement of the lipids in the Gastrodia rhizoma and the optimum recommendation quantity of Gastrodia rhizoma is 10% to quantity of food composition.

역행성 심정지 도관 삽입을 위한 술 중 경식도심초음파의 유용성

유미숙;최원주;김정원;박장수;김경태;김지연;어상일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Background: Retrograde cardioplegia catheter (RCC) insertion is one of methods for administration of cardioplegics during cardiopulmonary bypass (CPB). However its success rate depends on only surgeon's experience. We thought the transesophageal echocardiography (TEE) can guide the R CC insertion, because TEE is commonly used for monitoring status of heart during cardiac surgery. This study was designed to evaluate the RC C insertion time by TEE guidance versus conventional method without T EE guidance. Methods: Sixty patients who were scheduled to undergo elective coronary artery bypass graft (CABG) surgery under general anesthesia were divided into groups as follows: group T [RCC insertion into coronary sinus (CS) by TEE guidance, n=30] and group C [RCC insertion into CS by conventional method, n=30]. We recorded the time of insertion of RCC in to CS in two groups. RCC insertion was done by TEE guidance in case that time was over two minutes by conventional methods in group C. Results: The overall time of RCC insertion into CS was 63.8 ± 23.6 seconds in the Group T and 102.3 ±55.7 seconds in the Group C, respectively (p=0.001). There were no complications during RCC into CS by T EE guidance. Conclusions: TEE guidance for RCC insertion into CS is shorten the time of insertion.

배양된 해마 조직 절편에서 Beta-Amyloid Peptide의 신경 독성 효과

박정선,조미선,정연주,이경은 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Alzheimer's disease(AD) is primarily characterized by neurofibrillary tangles, senile plaques, and neurodegeneration. The major component of senile plaques is the beta-amyloid peptide(A B), Which is considered to have a causal role in AD. However, the biological activities of AB in AD has not been clearly defined. In this study we have investigated the effects of AB 25-35 fragment to neurons using organotypic hippocampal slice culture system which maintained intact hippocampal synaptic circuit and anatomy. Hippocampal slice culture is prepared from rat pos-tnatal 10-old days and after 14 days culture, slices were treated with 10uM AB 25-35 fragment. Neuronal death was measured with propidium iodide(PI) uptake and NeuN, neuronal marker, staining. After treatment of AB 25-35 fragment for 3days or 7days on hippocampal slice culture, we observed the increased PI uptake and the decreased number of NeuN-stained neuron in CA1 region of hippocampal pyramidal layer or dentate gyrus. These results suggested that AB 25-35 fragment exerts the neurotoxicity in hippocampal slice culture.

男子大學生의 衣服購買行動에 관한 연구

朴定涓,徐美亞 漢陽大學校 韓國生活科學硏究所 1990 韓國 生活 科學 硏究 Vol.- No.9

This research was designed to analyze empirically the clothing purchasing behavior of the male college students, and to clarify the effect of their external variables upon their clothing purchasing behavior. The study used the questionarize method. The subjects of the study were 434 male college students living in Seoul. As for the analytic method, frequency and relative frequency were used. X2 - Cross tabulation was applied in examining the relationship between external variables and clothing purchasing behavior. The major findings are as follows, 1.Clothing Purchasing Behavior 1) Stage of Problem Recognition : The main motive of purchasing the clothing was to replace the worn-out clothes, And the purchase was initiated by in the order of themselves and their parents. 2) Stage of Search Information : They gathered the information mainly from the items displayed in the stores. And they visited two of three stores before the purchase. Most of interviewees made plans before the purchase. 3) Stage of Evaluating Alternative In evaluating the alternative, DesignㆍStyle, Price, Color Pattern in sequence influenced the selection of the products. 4) Stage of Deciding Purchase ; In the stage of deciding purchase, markets were usually used. Most of the purchasers accompanied their parents but made the decision by themselves. Less than 10,000 won were spent on clothes a month on the average. And in most of the case, their parents bore the expenses. The study showed that half of the interviewees had an experience on repeated purchase. 2.Clothing Purchasing Behavior Concerning the External Variables 1) As the purchasers grew older, the rate of expenses which their parents bore was decreasing and the frequency of independent purchase was increasing. 2) Students in art schools gather information from desplayed clothes, are less frequently accompanied by their parents and less influenced by companions when they purchase clothes more than students in other colleges. 3) Students who have many brothers and sisters are less suggested about the needs of purchasing clothes by parents, and more accompanied by their brothers and sisters. 4) The more incomes people got, the more answers they gave that they bought new clothes because of weariness of old clothes. They prefered department stores. As a family's income is high, the expense of purchasing clothes of them is increasing.

알쯔하이머병 환자 혈청에서의 베타 아밀로이드 단백질에 대한 특이 항체량 측정 : 알쯔하이머병의 생화학적 진단지표 개발 Development of Biomarker for Alzheimer's Disease Diagnosis

소정온,허지연,심혜진,김종원,나덕렬,이필휴,정선주,박문호,주인수,송미숙,김영호,묵인희 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

Background:Alzheimer's disease (Ad) is a neurodegenerative disorder that is rapidly increasing with the aging society, requiring a need for early diagnosis and prevention. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. AD is characterized by deposition of senile plaques and neurofibrillary tangles in the brain. Aβ peptide in senile plaques seems to play a central role in the neuropathology of AD. Several biochemical markers for AD are available, including reduced Aβ protein, a change in ratio between Aβ40 and 42 and increased level of tau protein in the cerebrospinal fluid (CSF). Methods:This study analyzes anti-Aβ antibody from serums of AD patients using the ELISA. The levels of anti-Aβ antibody from patients with idiopathic Parkinson's disease or stroke and from normal control were compared to that of AD patients. Results:Our results showed a significantly lower anti-Aβ antibody level in AD compared to those with other neurological diseases or control. Conclusions:These data showed that the anti-Aβ antibody level in the serum may be used to diagnose the presence of AD.

남성 근로자의 고혈압 유무에 따른 열량 영양소 및 지질 섭취 상태 비교

김연정,김수근,백윤미,김미경 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

목적: 본 연구에서는 정상 근로자와 고혈압인 근로자간의 식이섭취 실태의 차이를 파악하여 효과적인 사업장 고혈압 관리 방안에 대한 기초 자료를 얻고자 하였다. 방법: 연구 대상은 임의 추출한 발전소 근무자 427명을 대상으로 하였으며, 신장, 체중과 혈압을 측정하고, 생활습관 및 식품섭취빈도조사를 실시하여 자료가 완전한 338명을 분석하였다. 대상자를 정상, 경계 고혈압과 고혈압군으로 분류하여 각 군 간 연령, 신장, 체중, 체질량지수, 혈압 등 인체계측 결과와 흡연, 음주, 운동 등 생활습관 및 열량 영양소 섭취 상태, 지질 성취상태의 결과를 비교하였다. 결과: 연령과 신장은 세 군 간 차이가 없었으나 체중과 체질량지수는 고혈압 군과 다른 두 군 간에 유의한 차이를 보였다(p<0.05). 세 군 모두 흡연율은 40.0% 미만으로 차이가 없었으나 흡연량은 경계 고혈압과 고혈압군이 정상군보다 유의하게 더 많았다(p<0.05). 음주 습관에서 음주 빈도와 음주량은 경계 고혈압군이 다른 두 군보다 더 높았으며, 음주량만 통계적으로 유의한 차이가 있었다(p<0.05). 운동 빈도는 주3회 이상 하는 경우가 정상군에서 높았으나 세 군 간에 차이가 없었다. 총 열량 섭취량은 세 군 간 차이가 없었으나, 탄수화물, 단백질, 지방 섭취량과 3대 영양소의 에너지 섭취 비율은 세 군 간에 유의한 차이가 있었으며, 고혈압 군이 다른 군 보다 탄수화물의 섭취는 많고, 지방 섭취는 적었다(p<0.05). 정상군에 비해 경계 고혈압과 고혈압군이 콜레스테롤 섭취량이 상대적으로 적었으나, 유의한 차이가 없었다. P / M /S비도 세 군 간에 유의한 차이가 없었다. 경계 고혈압군은 총 열량, 단백질, 지방 과잉 섭취자의 비율이 높았고, 고혈압군은 탄수화물, 지방 과잉섭취자의 비율이 높았으나 통계적으로 유의하지는 않았다. 결론: 본 연구에서 정상 근로자와 고혈압 환자 간에 탄수화물 섭취에 유의한 차이가 있었으며, 경계 고혈압과 고혈압군에서 열량 영양소 섭취와 지방산 섭취가 상대적으로 불균형하였다. 이러한 연구결과에 따라 고혈압뿐만 아니라 경계 고혈압단계에 있는 근로자를 조기에 발견하여 식습관을 포함한 생활습관을 개선하도록 관리할 필요가 있다. Objectives: The purpose of this study was to investigate the difference in nutrient intake between normotensive workers and hypertensive workers to obtain basic data for developing a program of effective hypertension care at work. Methods: The subjects were 338 male workers. We measured physical data by medical examination and collected lifestyle data by questionnaire survey. Dietary intakes were collected using a food frequency questionnaire. We classified the subjects into normal, prehypertension, and hypertension groups, and compared the results of age, body mass index (BMI), blood pressure (BP), lifestyles and energy nutrients and lipids intake. Results: There were significant differences in both weight and BMI between the hypertension group and the other two groups (p<0.05). The smoking levels of the prehypertension group and hypertension group were significantly higher than that of the normal group (p<0.05). The three groups also showed significant differences in drinking amount (p<0.05). There were significant differences in carbohydrate and protein intakes and the ratio of carbohydrate, protein, and fat intake (p<0.05). Conclusion: In this study, there was a significant difference in carbohydrate intake between normotensive and hypertensive workers, and the intake of energy nutrients and fatty acids in the prehypertension group and hypertension groups was unbalanced. Therefore, early diagnosis of workers with hypertension and prehypertension is necessary to improve lifestyles particularly food habit.

식사를 통한 N-Nitrosamine의 추정 섭취량 평가

신정혜,김연희,이수정,손미예,성낙주 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.1

단체급식소 12개소의 식단을 수거하여 각 메뉴별 및 1인분 식단별 NA 함량을 분석하였고 인공소화 기법을 활용하여 체내에서 생성 가능한 NA의 함량을 예측하였다. 육류와 어패류를 주재료로 요리된 메뉴들의 인공소화 전·후 NA 함량을 분석한 결과 멸치볶음에서 NDMA 함량이 흔적량 ~ 4.8 ㎍/kg으로 가장 높았고, 채소류를 주재료로 한 메뉴들에서는 불검출에서 흔적량의 NDMA가 정량되었으며, 인공소화 후에도 흔적량 이하로 정량되었다. 1인 분량의 식사를 수거하여 인공소화 전·후의 NA를 분석한 결과 NDMA는 인공소화 전 0.20 ~ 0.78 ㎍/kg의 범위였으나 인공소화 후에는 0.43 ~ 0.80 ㎍/kg으로 약간 증가하였다. 상기의 분석 결과를 기초로 하여 성인 1일 NA 섭취량을 계산한 결과 0.60 ~ 2.34 ㎍/day/person이며, 인공소화를 통한 체내에서의 생성량을 고려하면 최대 5.15㎍/day/person으로 추정된다. N-nitrosamine (NA) contents depending on simulated gastric digestion were analyzed with 12 kinds of diets collected from institutional food service those diets were estimated the total NA amounts including both intake from food directly and its endogenous formation in human body from simulated gastric digestion. NA was determined in dishes of meats, fished and vegetables before and after simulated gastric digestion. N-nitrosodimethylamine (NDMA) contents were from not detected(ND) to 4.8 ㎍/kg in dishes of meats and fishes. After digestion, its contents increased and the highest level was 3.0 ㎍/kg in panbroiled dried anchovy. In vegetable dishes, NDMA was detected as ND ~ trace before and after digestion. The contents of NDMA in diets collected from institutional food service were 0.20 ~ 0.78 ㎍/kg, 0.43 ~ 0.80 ㎍/kg before and after digestion, respectively. The average intake of Na per day to Korean, based on the above data, was 0.60 ~ 2.34 ㎍/day/person. The maximum daily intake of NA was reduced to 5.15 ㎍/day/person when considering NA amounts formed endogenously by simulated gastric digestion.