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- 저자 : ( Zhongyi Xu ) (검색결과 3 건)
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Severe Cutaneous Adverse Reactions: A Single-Center Retrospective Study of 173 Patients in China
( Zhongyi Xu ),( Jie Shen ),( Yiwen Yang ),( Ruoyue Yuan ),( Leihong Flora Xiang ),( Chengfeng Zhang ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.5
Background: Severe cutaneous adverse reactions (SCAR) to drugs are a crucial public health issue and the use of systemic corticosteroids in SCAR has been controversial. Objective: To analyze clinical features, causative drugs, treatment, outcomes, and prognostic factors of SCAR in the case-series of 173 patients, and add more information to the debate of using systemic corticosteroids in SCAR management. Methods: A retrospective study of 173 SCAR patients diagnosed with drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) or acute generalized exanthematous pustulosis (AGEP) at a tertiary care institution in China between January 2014 and December 2017 was conducted. Results: Of 173 patients, allopurinol, carbamazepine, and antibiotics are the most frequently implicated drugs for DRESS (40.4%), SJS/TEN (26.0%), and AGEP (40.0%) respectively. Moreover, there is a strongly negative correlation between early corticosteroids use and the progression (p=0.000) and severity (p=0.01) of skin lesions. However, there is no association between early corticosteroids use and the mortality of SCAR (odds ratio: 1.01, 95% confidence interval: 0.95∼1.08). In addition, lymphadenopathy, eosinophilia, and interval from onset to corticosteroids treatment were correlated with SCAR prognosis. Conclusion: Prompt short-course systemic corticosteroids use is associated with early-stage skin lesions remission without influencing the disease mortality. Lymphadenopathy and eosinophilia were the independent poor prognostic factors of SCAR. (Ann Dermatol 31(5) 545∼ 554, 2019)
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Multi-scale Modeling for the Stress Analysis of Acrylic Joints in a Hybrid Structure
Yanfeng Zheng,Yaozhi Luo,Xian Xu,Chao Yang,Zhongyi Zhu,Yuekun Heng 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.4
The central detector at the Jiangmen Underground Neutrino Observatory (JUNO) is a hybrid structure system consisting of an inner acrylic sphere and an outer stainless steel reticulated shell. The stress distributions of the acrylic joints must be accurately simulated to avoid “crazing”. To balance the accuracy and effi ciency of the stress analysis, a multi-scale modeling method using mixed-dimensional coupling is proposed. A framework and a generalized procedure are developed to instruct the modeling and analysis. A multi-scale model consisting of a single refi ned acrylic joint and equipped with simplifi ed joints is proposed and discussed. A comparison of the results using the multi-scale model with a cluster of 3 × 3 refi ned joints reveals that the diff erence is less than 5%, while the ratio of the computation resource cost and the time consumption is approximately only 1/7 and 1/5, respectively. The stress distributions of the acrylic joints in the central detector are obtained using the proposed multi-scale model.
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Xinyang Wu,Shuting Chen,Zixin Zhang,Yihan Zhang,Pingmei Li,Xinyi Chen,Miaomiao Liu,Qian Lu,Zhongyi Li,Zhongyan Wei,Pei Xu 한국식물병리학회 2023 Plant Pathology Journal Vol.39 No.5
Cowpea mild mottle virus (CPMMV) is a global plant virus that poses a threat to the production and quality of legume crops. Early and accurate diagnosis is essential for effective managing CPMMV outbreaks. With the advancement in isothermal recombinase polymerase amplification and lateral flow strips technologies, more rapid and sensitive methods have become available for detecting this pathogen. In this study, we have developed a reverse transcription recombinase polymerase amplification combined with lateral flow strips (RT-RPA-LFS) method for the detection of CPMMV, specifically targeting the CPMMV coat protein (CP) gene. The RT-RPA-LFS assay only requires 20 min at 40°C and demonstrates high specificity. Its detection limit was 10 copies/μl, which is approximately up to 100 times more sensitive than RT-PCR on agarose gel electrophoresis. The developed RT-RPA-LFS method offers a rapid, convenient, and sensitive approach for field detection of CPMMV, which contribute to controlling the spread of the virus.
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