http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Zhongyang Sun ) (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
CLOSED CONVEX SPACELIKE HYPERSURFACES IN LOCALLY SYMMETRIC LORENTZ SPACES
Sun, Zhongyang Korean Mathematical Society 2017 대한수학회보 Vol.54 No.6
In 1997, H. Li [12] proposed a conjecture: if $M^n(n{\geqslant}3)$ is a complete spacelike hypersurface in de Sitter space $S^{n+1}_1(1)$ with constant normalized scalar curvature R satisfying $\frac{n-2}{n}{\leqslant}R{\leqslant}1$, then is $M^n$ totally umbilical? Recently, F. E. C. Camargo et al. ([5]) partially proved the conjecture. In this paper, from a different viewpoint, we study closed convex spacelike hypersurface $M^n$ in locally symmetric Lorentz space $L^{n+1}_1$ and also prove that $M^n$ is totally umbilical if the square of length of second fundamental form of the closed convex spacelike hypersurface $M^n$ is constant, i.e., Theorem 1. On the other hand, we obtain that if the sectional curvature of the closed convex spacelike hypersurface $M^n$ in locally symmetric Lorentz space $L^{n+1}_1$ satisfies $K(M^n)$ > 0, then $M^n$ is totally umbilical, i.e., Theorem 2.
-
Closed convex spacelike hypersurfaces in locally symmetric Lorentz spaces
Zhongyang Sun 대한수학회 2017 대한수학회보 Vol.54 No.6
In 1997, H. Li {\cite{Li97}} proposed a conjecture: if $M^{n} (n\geqslant3)$ is a complete spacelike hypersurface in de Sitter space $S_{1}^{n+1}(1)$ with constant normalized scalar curvature $R$ satisfying $\frac{n-2}{n}\leqslant R\leqslant1$, then is $M^{n}$ totally umbilical? Recently, F.~E.~C.~Camargo et al.~(\cite{Camargo08}) partially proved the conjecture. In this paper, from a different viewpoint, we study closed convex spacelike hypersurface $M^{n}$ in locally symmetric Lorentz space $L^{n+1}_1$ and also prove that $M^{n}$ is totally umbilical if the square of length of second fundamental form of the closed convex spacelike hypersurface $M^{n}$ is constant, i.e., Theorem 1. On the other hand, we obtain that if the sectional curvature of the closed convex spacelike hypersurface $M^{n}$ in locally symmetric Lorentz space $L_{1}^{n+1}$ satisfies $K(M^{n})>0$, then $M^{n}$ is totally umbilical, i.e., Theorem 2.
-
Selection of Stable Reference Genes for Real-Time Quantitative PCR Analysis in Edwardsiella tarda
( Zhongyang Sun ),( Jia Deng ),( Haizhen Wu ),( Qiyao Wang ),( Yuanxing Zhang ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.1
Edwardsiella tarda is a gram-negative pathogenic bacterium in aquaculture that can cause hemorrhagic septicemia in fish. Many secreted proteins have already been identified as virulent factors of E. tarda. Moreover, since virulent phenotypes are based on the expression regulation of virulent genes, understanding the expression profile of virulent genes is important. A quantitative RT-PCR is one of the preferred methods for determining different gene expressions. However, this requires the selection of a stable reference gene in E. tarda, which has not yet been systematically studied. Accordingly, this study evaluated nine candidate reference genes (recA, uup, rpoB, rho, topA, gyrA, groEL, rpoD, and 16S rRNA) using the Excel-based programs BestKeeper, GeNorm, and NormFinder under different culture conditions. The results showed that 16S rRNA was more stable than the other genes at different culture growth phases. However, at the same culture time, topA was identified as the reference gene under the conditions of different strains, different culture media, and infection, whereas gyrA was identified under the condition of different temperatures. Thus, in experiments, the expression of gapA and fbaA in E. tarda was analyzed by RT-qPCR using 16S rRNA, recA, and uup as the reference genes. The results showed that 16S rRNA was the most suitable reference gene in this analysis, and that using unsuitable reference genes resulted in inaccurate results.
-
Daxian Wu,Qunfang Rao,Zhongyang Xie,Xiaoqing Zhu,Jian Wu,Hainv Gao,Jingyu Zhang,Zhouhua Hou,Xiaoyu Cheng,Zeyu Sun 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.4
Background/Aims: Acute-on-chronic liver failure (ACLF) is a catastrophic illness. Few studies investigated the prognostic value of vitamin D-binding protein (VDBP) for hepatitis B virus (HBV)-related ACLF (HBV-ACLF) resulted in conflicting results. Methods: Two prospective HBV-ACLF cohorts (n=287 and n=119) were enrolled to assess and validate the prognostic performance of VDBP. Results: VDBP levels in the non-survivors were significantly lower than in the survivors (P<0.001). Multivariate Cox regression demonstrated that VDBP was an independent prognostic factor for HBV-ACLF. The VDBP level at admission gradually decreased as the number of failed organs increased (P<0.001), and it was closely related to coagulation failure. The areas under the receiver operating characteristic curve (AUCs) of the Child-Pugh-VDBP and chronic liver failuresequential organ failure assessment (CLIF–SOFA)-VDBP scores were significantly higher than those of Child-Pugh (P<0.001) and CLIF-SOFA (P=0.0013). The AUCs of model for end-stage liver disease (MELD)-VDBP were significantly higher than those of MELD (P= 0.0384) only in the case of cirrhotic HBV-ACLF patients. Similar results were validated using an external multicenter HBV-ACLF cohort. By longitudinal observation, the VDBP levels gradually increased in survivors (P=0.026) and gradually decreased in non-survivors (P<0.001). Additionally, the VDBP levels were found to be significantly decreased in the deterioration group (P=0.012) and tended to be decreased in the fluctuation group (P=0.055). In contrast, they showed a significant increase in the improvement group (P=0.036). Conclusions: The VDBP was a promising prognostic biomarker for HBV-ACLF. Sequential measurement of circulating VDBP shows value for the monitoring of ACLF progression.
-
An Xueying,Wang Rongliang,Lv Zhongyang,Wu Wenshu,Sun Ziying,Wu Rui,Yan Wenjin,Jiang Qing,Xu Xingquan 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m6A) modification may have an important role in OA pathogenesis. This study aimed to investigate the role of m6A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes. Mechanistically, the m6A modification and relative downstream targets in osteoarthritic cartilage were assessed by methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing, which indicated that the expression of frizzled-related protein (FRZB), a secreted Wnt antagonist, was abnormally decreased and accompanied by high m6A modification in osteoarthritic cartilage. In vitro dysregulated WTAP had positive effects on β-catenin expression by targeting FRZB, which finally contributed to the cartilage injury phenotype in chondrocytes. Intra-articular injection of adeno-associated virus-WTAP alleviated OA progression in a mouse model, while this protective effect could be reversed by the application of a Wnt/β-catenin activator. In summary, this study revealed that WTAP-dependent RNA m6A modification contributed to Wnt/β-catenin pathway activation and OA progression through post-transcriptional regulation of FRZB mRNA, thus providing a potentially effective therapeutic strategy for OA treatment.
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
