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Unexpected Complications and Safe Management in Laparoscopic Pancreaticoduodenectomy
Yuichi Nagakawa,Yatsuka Sahara,Yuichi Hosokawa,Chie Takishita,Tetsushi Nakajima,Yousuke Hijikata,Kazuhiko Kasuya,Kenji Katsumata,Akihiko Tsuchida Korean Society of Gastrointestinal Cancer 2017 Journal of digestive cancer reports Vol.5 No.1
Although laparoscopic pancreaticoduodenectomy (LPD) is considered as minimally invasive surgery, an advanced level of laparoscopic skill is still required. LPD comprises various procedures including reconstruction. Therefore, establishment of a safe approach at each step is needed. Prevention of intraoperative bleeding is the most important factor in safe completion of LPD. The establishment of effective retraction methods is also important at each site to prevent vascular injury. I also recommend the "uncinate process first" approach during initial cases of LPD, in which the branches of the inferior pancreaticoduodenal artery are dissected first, at points where they enter the uncinate process. This approach is performed at the left side of the superior mesenteric artery (SMA) before isolating the pancreatic head from the right aspect of the SMA, which allows safe dissection without bleeding. Safe and reliable reconstruction is also important to prevent postoperative complications. Laparoscopic pancreatojejunostomy requires highly skilled suturing technique. Pancreatojejunostomy through a small abdominal incision, as in hybrid-LPD, facilitates reconstruction. In LPD, the surgical view is limited. Therefore, we must carefully verify the position of the pancreaticobiliary limb. A twisted mesentery may cause severe congestion of the pancreaticobiliary limb following reconstruction, resulting in severe complications. We must secure the appropriate position of the pancreaticobiliary limb before starting reconstruction. We describe the incidence of intraoperative and postoperative complications and appropriate technique for safe performance of LPD.
A Study on Automation of Network Maintenance in Telecom Carriers for Zero-Touch Operations
Aiko OI,Ryosuke SATO,Yuichi SUTO,Kosuke SAKATA,Motomu NAKAJIMA,Tsuyoshi FURUKAWA 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
In recent years, there are many work efficiency efforts in particular automation of business processes in various industry. The same trend applies to the network operations of telecommunication carriers; however, although automation of service fulfillment, such as developing network services, is progressing, automation of service assurance such as responding to network failure has not progressed. Currently, network maintenance personnel have independently developed tools for automation of network maintenance (such as troubleshooting) process partially and they are manually performing maintenance tasks by coordinating multiple groups of tools. However, in view of the future decrease in the working population, work efficiency must be further improved. Following this situation, this article focuses on further automation of network maintenance process, by developing technologies to orchestrate existing automation tools. In this paper, handling network failures among network maintenance work is targeted, the challenges and the requirements for expansion in the range of automation is discussed, after discussing current automation of network maintenance at telecom carriers in the real world. After that an implementation method that satisfies these requirements using our orchestrator and OSS products is proposed and evaluated. By defining a workflow of network maintenance that makes each process reusable, it becomes easy to create new workflow and update the one, and furthermore it was found that by reviewing how to code the workflow, it was possible to significantly improve processing performance.
( Yutthana Pengjam ),( Harishkumar Madhyastha ),( Radha Madhyastha ),( Yuya Yamaguchi ),( Yuichi Nakajima ),( Masugi Maruyama ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Osteoporosis is a bone pathology leading to increased fracture risk and challenging the quality of life. The aim of this study was to evaluate the effect of an anthraquinone glycoside, aloin, on osteogenic induction of MC3T3-E1 cells. Aloin increased alkaline phosphatase (ALP) activity, an early differentiation marker of osteoblasts. Aloin also increased the ALP activity in adult human adipose-derived stem cells (hADSC), indicating that the action of aloin was not cell-type specific. Alizarin red S staining revealed a significant amount of calcium deposition in cells treated with aloin. Aloin enhanced the expression of osteoblast differentiation genes, Bmp-2, Runx2 and collagen 1a, in a dose-dependent manner. Western blot analysis revealed that noggin and inhibitors of p38 MAPK and SAPK/JNK signals attenuated aloin-promoted expressions of Bmp-2 and Runx2 proteins. siRNA mediated blocking of Wnt-5a signaling pathway also annulled the influence of aloin, indicating Wnt-5a dependent activity. Inhibition of the different signal pathways abrogated the influence of aloin on ALP activity, confirming that aloin induced MC3T3-E1 cells into osteoblasts through MAPK mediated Wnt and Bmp signaling pathway.
Pengjam, Yutthana,Madhyastha, Harishkumar,Madhyastha, Radha,Yamaguchi, Yuya,Nakajima, Yuichi,Maruyama, Masugi The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Osteoporosis is a bone pathology leading to increased fracture risk and challenging the quality of life. The aim of this study was to evaluate the effect of an anthraquinone glycoside, aloin, on osteogenic induction of MC3T3-E1 cells. Aloin increased alkaline phosphatase (ALP) activity, an early differentiation marker of osteoblasts. Aloin also increased the ALP activity in adult human adipose-derived stem cells (hADSC), indicating that the action of aloin was not cell-type specific. Alizarin red S staining revealed a significant amount of calcium deposition in cells treated with aloin. Aloin enhanced the expression of osteoblast differentiation genes, Bmp-2, Runx2 and collagen 1a, in a dose-dependent manner. Western blot analysis revealed that noggin and inhibitors of p38 MAPK and SAPK/JNK signals attenuated aloin-promoted expressions of Bmp-2 and Runx2 proteins. siRNA mediated blocking of Wnt-5a signaling pathway also annulled the influence of aloin, indicating Wnt-5a dependent activity. Inhibition of the different signal pathways abrogated the influence of aloin on ALP activity, confirming that aloin induced MC3T3-E1 cells into osteoblasts through MAPK mediated Wnt and Bmp signaling pathway.
Development of a Cloud Profiling FM-CW Radar at 95 GHz and its Performance
Toshiaki TAKANO,Yumiro SUGA,Ken-ichi AKITA,Youhei KAWAMURA,Kurt SAKAI,Hiroshi KUMAGAI,Hiroshi KUROIWA,Yuichi OHNO,Hiroaki Horie,Tamio TAKAMURA,Yuji NAKANISHI,Teruyuki NAKAJIMA 대한전자공학회 2003 ITC-CSCC :International Technical Conference on Ci Vol.2003 No.7