선삭가공 중 신경망을 이용한 채터진동의 감시

남용석(Yong Seak Nam),조종래(Jong Rae Cho),김재실(Chae Sil Kim),정윤교(Youn Gyo Jung) Korean Society for Precision Engineering 2001 한국정밀공학회지 Vol.18 No.4

선삭가공 중 Neural network를 이용한 Chatter vibration의 감시

남용석(Yong-Seak Nam),조종래(Jong-Rae Cho),정윤교(Youn-Gyo Jung) 한국정밀공학회 1999 한국정밀공학회 학술발표대회 논문집 Vol.1999 No.11월

신경망을 이용한 선삭가공 시 Chatter vibration의 감시

남용석(Yong-Seak Nam),조종래(Jong-Rae Cho),정윤교(Youn-Gyo Jung) 한국생산제조학회 2000 한국공작기계학회 춘계학술대회논문집 Vol.2000 No.4

생활중심 주제통합 교육과정 운영이 지적장애학생의 자기관리역량에 미치는 효과

조용락 ( Cho¸ Yong Rak ),김우리 ( Kim¸ Woori ),권주석 ( Kwon¸ Ju Seak ) 한국지적장애교육학회(구 한국정신지체아교육학회) 2020 지적장애연구 Vol.22 No.4

본 연구의 목적은 생활중심 주제통합 교육과정 운영이 지적장애학생의 자기관리역량(자신감, 자기조절능력)에 미치는 효과를 검증하는 것이다. 실험은 대상자 간 중다간헐기초선 설계를 사용하여 수행되었으며, 연구대상은 특수학교에 재학 중인 중학교 1학년 지적장애학생 세명을 대상으로 하였다. 생활중심 주제통합 교육과정은 생활 영역과 관련된 주제(건강과 안전, 경제생활, 여가생활, 대인관계 및 예절, 지역사회 서비스 이용)를 선정하여, 다섯 개 교과(국어, 수학, 사회, 과학, 진로와 직업)에서 해당 주제와 관련된 내용을 분석하여 새롭게 통합단원과 내용을 구성하였다. 기초선에서는 기존의 교육과정을 운영하여 수업을 실시하였고, 중재단계에서는 생활중심 주제통합 교육과정을 적용한 30회기의 수업을 실시하였으며, 유지 단계에서는 기초선과 동일한 조건의 수업을 실시하였다. 또한, 수업이 끝난 후에는 학생별로 자신감과 자기조절능력 검사를 실시하였으며, 검사는 3회기에 한 번씩 자신감에 대해서 총 10회, 자기조절능력에 대해 총 10회 실시되었다. 연구 결과, 생활중심 주제통합 교육과정은 지적장애학생들의 자신감과 자기조절능력 향상에 효과적이었다. 중재를 종료한 후에도 그 효과는 유지되었다. 한편, 생활중심 주제통합 교육과정의 주제에 따라 자신감이나 자기조절능력의 향상 정도가 달라졌다. 본 연구의 결과를 통해 생활 영역과 관련된 교과 간 주제통합 교육과정이 자기관리역량을 향상시키는데 효과적임 확인할 수 있었다. The purpose of this study was to demonstrate the effects of life skill theme-based curriculum on improving self-management competency (self-confidence, self-regulation) of students with intellectual disabilities. The multiple-probe across subject design was used and three seventh-grade students with intellectual disabilities participated in the study. The theme-based curriculum selected the themes relative to life skills and developed units and contents in the units by integrating the contents in five subject matters (reading, math, social studies, science, and vocation). Traditional instruction was provided in a baseline phase; theme-based curriculum consisted of 30 sessions was implemented in an intervention phase and maintenance phase was followed. after instruction, each student was tested for self-confidence and self-regulation skills. The test was conducted once every three sessions, 10 times for self-confidence and 10 times for self-regulating ability. The results revealed that life skill theme-based curriculum was effective on improving self-confidence and self-regulation abilities of students with intellectual disabilities and the effects was maintained. In the meantime, levels of the effects on self-confidence and self-regulation varied by the themes. The results confirmed that the theme-based curriculum related to life skills was effective on improving the self-management competency.

Efficacy and safety of autologous adipose tissue-derived stem cell therapy for children with refractory Crohn’s complex fistula: a Phase IV clinical study

Yu Jeong Cho,Hyunhee Kwon,Yong Jae Kwon,Kyung Mo Kim,Seak Hee Oh,Dae Yeon Kim 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.1

Purpose: Autologous adipose tissue-derived stem cells (ASCs) have been proposed for patients with refractory Crohn disease, but research is lacking in pediatric patients. This Phase IV study evaluated the efficacy and safety of ASCs in children with refractory Crohn’s fistulae. Methods: Patients with a refractory Crohn’s fistula who did not have conventional therapy for more than 3 months or with a recurrent complex Crohn’s fistula were included. All patients were at least 14 years old. Patients with infection, poor condition, or active Crohn disease with a disease activity index of 450 and above were excluded. Five patients were treated with ASCs from 2014 to 2015 in Asan Medical Center. ASC administration was adjusted according to fistula size (1 mL per ㎠). We evaluated the efficacy and safety 8 weeks after injection and followed patients for 6 months. Results: Fistulae were healed in 4 patients by 8 weeks after ASC injection. Of these 4 patients, 1 had complete fistula closure and sustainability after 6 months. The other 3 with healing effects had less than 50% fistula closure by 6 months. None of these 4 patients have persistent fistulae. One patient had no healing effect, and seton ligation was performed 8 months after ASC injection. There were no adverse effects related to ASC administration. Conclusion: ASC therapy is a simple and well-tolerated therapeutic option for children with refractory Crohn’s complex fistulae. Complete closure was well-sustained. However, more data from a larger number of patients are needed.

Efficacy and safety of autologous adipose tissue-derived stem cells (ASCs) therapy for children with refractory Crohn’s complex fistula

Yu Jeong CHO,Hyunhee KWON,Yong Jae KWON,Kyung Mo KIM,Seak Hee OH,Dae Yeon KIM 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.10

The Experience with Diverting Ostomy for Crohn’s Pancolitis in Pediatric Patients

Hyunhee KWON,Yu Jeong CHO,Yong Jae KWON,Kyung Mo KIM,Seak Hee OH,Jung-Man NAMGOONG,Seong Chul KIM,Dae Yeon KIM 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.10

Effect of everolimus rescue therapy for acute cellular rejection following pediatric living donor liver transplantation: Report of one case

Shin Hwang,Jung-Man Namgoong,Seak Hee Oh,Kyung Mo Kim,Chul-Soo Ahn,Hyunhee Kwon,Yu Jeong Cho,Yong Jae Kwon 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.2

Acute cellular rejection (ACR) after pediatric living donor liver transplantation (LDLT) is often curable with steroid pulse therapy, but a few pediatric patients show steroid-resistant ACR, which is difficult to control. We report the effect of everolimus as a rescue therapy for ACR in a case of pediatric LDLT. The patient was a 11-year-old girl who was admitted due to subacute liver failure of unknown cause. LDLT operation using a modified right liver graft from her mother was performed. The graft-recipient weight ratio was 1.30. The explant liver showed massive hepatic necrosis. The patient recovered uneventfully with immunosuppression using tacrolimus and low-dose steroid. However, at postoperative day (POD) 20, the liver enzyme levels began to increase. The first liver biopsy taken at POD 25 showed moderate ACR with rejection activity index (RAI) score of 7. At that time, steroid pulse therapy was performed, but the patient did not respond and the liver enzyme levels increased further. The second liver biopsy taken at POD 40 showed moderate ACR with RAI score of 7. At this time, everolimus was administered, and soon after that, liver enzyme levels had gradually improved. Currently, the patient is doing well for 44 months to date without any abnormal findings. The maintenance target trough concentrations were tacrolimus 5 ng/ml and everolimus 3 ng/ml. Our case demonstrated the effect of rescue therapy using everolimus for ACR following pediatric LDLT. Further studies are needed to assess the role of everolimus in pediatric liver transplant recipients suffering from ACR.

Living donor liver transplantation with total pancreatectomy and portal vein homograft replacement in a pediatric patient with advanced pancreatoblastoma

Jung-Man Namgoong,Shin Hwang,Seak Hee Oh,Kyung Mo Kim,Gil-Chun Park,Chul-Soo Ahn,Hyunhee Kwon,Yu Jeong Cho,Yong Jae Kwon 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.1

Pancreatoblastoma is a malignant exocrine pancreatic tumor that is usually present in childhood. We herein present one case of pediatric living donor liver transplantation (LDLT) combined with spleen-preserving regional total pancreatectomy and portal vein homograft interposition in a 4-year-old boy with advanced pancreatoblastoma invading the portal and superior mesenteric veins. The size of the pancreatoblastoma was gradually reduced along systemic chemotherapy, thus we decided to perform surgery to remove it completely. A cold-stored fresh iliac vein homograft was prepared. Initially, a spleen-preserving distal pancreatectomy was performed. Thereafter, a completion regional total pancreatectomy was performed under superior mesenteric vein-vena cava bypass. A left liver graft from his mother was implanted according to the standardized procedures with portal vein interposition. This patient recovered uneventfully and is currently undergoing scheduled adjuvant chemotherapy. To our knowledge, this is the world-second case of pediatric LDLT for advanced pancreatoblastoma. Availability of fresh vein homografts is helpful to expand the indication of pediatric LDLT.

실험적 고혈압 백서의 심맥관계 기능조절에 있어서 중추 Opiate System의 역할

김기원(Kee-Won Kim),곽용근(Yong-Geun Kwak),채준석(Joon-Seak Chae),조규박(Kyu-Park Cho) 대한약리학회 1987 대한약리학잡지 Vol.23 No.2

Morphine을 비롯한 opioid peptide가 말초 또는 중추에 투여시 혈압하강과 심박동수감소를 보이며 opiate 수용체 길항제인 naloxone에 의해 길항됨이 관찰되었던바 근래 몇몇 보고들은 중추신경내에서 adrenergic및 opioidergic system이 서로 관련되어 있음을 시사하고 있다. 이에 본 실험에서 고혈압 연구에 널리 사용되고 있는 2-kidney, 1-clip (2K1C) 방법으로 실험적 고혈압을 유발시킨 백서의 측뇌실내 clonidine또는 morphine의 심맥관계에 대한 효과와 각각의 차단제에 의한 영향 그리고 정상 및 고혈압상태 백서의 뇌내 β-endorphin의 함량과 specific opiate receptor binding을 정량하여 고혈압 유발에 따른 뇌내 opiate system의 변동을 관찰하였다. 2K1C 고혈압 또는 sham-operated대조백서에서 측뇌실내 clonidine (3-30μg/kg)은 용량에 비례하여 혈압하강과 심박동수감소를 일으켰으며 clonidine의 혈압강하 효과는 2K1C고혈압 백서에서 더욱 현저하였다. clonidine의 혈압강하효과는 고혈압 백서에서 측뇌실내 yohimbine 또는 naloxone 전처리에 의해 약화되었고 대조군에서는 yohimbine (30μg/kg, i.v.t.)에 의해 억제되었으나 naloxone (50μg/kg, i.v.t.)에 의해서는 영향 받지 않았다. clonidine과 마찬가지로 측뇌실내 morphine (10-100μg/kg)은 2K1C 고혈압 또는 sham-operated 대조백서에서 용량에 비례하여 혈압하강과 심박동수감소를 일으켰으며, morphine의 혈압강하효과는 2K1C 고혈압백서에서 더욱 현저하였다. 대조군과 고혈압군에서 morphine의 혈압강하효과는 naloxone 전처리에 의해 현저히 약화되었으나 yohimbine에 의해서는 영향 받지 않았다. 2K1C 시술익일부터 투여한 clonidine은 2K1C 시술에 의한 혈압 상승을 억제하였으며 naloxone (2 mg/kg, i.p.)에 의해 반전되었다. 2K1C 시술에 의해 고혈압이 유발된 백서의 뇌내 β-endorphin 함량은 sham-operated 군에 비하여 유의하게 감소되어 있었고 (3H)-naloxone의 specific binding의 Bmax는 증가되었으나 Kd치는 변동되지 않았다. 이상의 실험 성적은 뇌내 opiate계가 혈압조절에 중요한 역할을 담당하고 있으며 2K1C 고혈압백서의 고혈압상태 유지에 뇌내 opiate계의 기능저하가 일부관여하고 있음을 강력히 시사한다. The possible inolvement of central opiate system in the control of cardiovascular function and in the antihypertensive action of clonidine has been examined in unanesthetized rats with shamoperated or 2-kidney, 1-clip (2K1C) renal hypertension. In both groups of rats, intraventricular clonidine (3-30μg/kg) produced hypotension and bradycardia. Hypotensive action of clonidine was more potent in the hypertensive rats than in the normotensive sham-operated rats. Yohimbine (30μg/kg, i.v.t.) inhibited the hypotension and bradycardia produced by clonidine. Naloxone (50μg/kg, i.v.t.) inhibited the action of clonidine in 2K1C hypertensive rats but not influenced in the sham-operated rats. Intraventricular morphine (10-100μg/kg) also reduced rats. Intraventricular morphine (10-100μg/kg) also reduced blood pressure and heart rate in both groups of rats. But these effects were not affected by yohimbine, but antagonized by naloxone (50μg/kg, i.v.t.). Chronic treatment of 2K1C rats with clonidine (3 X 20μg/kg, p.o.,) for 14 days from 1 day after 2K1C operation) suppressed the development of hypertension and maintained the blood pressure in normal level and this errect of clonidine was abolished by naloxone (2 mg/kg, i. p.). In the 2K1C hypertensive rats, immunoreactive β-endorphin content was significantly decreased, but maximum binding (Bmax) of (³H)-naloxone was significantly increased in brain of 2K1C hypertensive rats. However, Kd value was not changed. These results suggest that the opioidergic component might be involved in the antihypertensive action of clonidine only in hypertensive and that central opiate system might play important roles in pathophysiology of development and maintenance of hypertension.