Nicorandil alleviated cardiac hypoxia/reoxygenation-induced cytotoxicity via upregulating ketone body metabolism and ACAT1 activity

Bai, Yan Ping,Han, Lei Sen The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.1

To study the effect of nicorandil pretreatment on ketone body metabolism and Acetyl-CoA acetyltransferase (ACAT1) activity in hypoxia/reoxygenation (H/R)-induced cardiomyocytes. In our study, we applied H9c2 cardiomyocytes cell line to evaluate the cardioprotective effects of nicorandil. We detected mitochondrial viability, cellular apoptosis, reactive oxygen species (ROS) production and calcium overloading in H9c2 cells that exposed to H/R-induced cytotoxicity. Then we evaluated whether nicorandil possibly regulated ketone body, mainly ${\beta}$-hydroxybutyrate (BHB) and acetoacetate (ACAC), metabolism by regulating ACAT1 and Succinyl-CoA:3-ketoacid coenzyme A transferase 1 (OXCT1) protein and gene expressions. Nicorandil protected H9c2 cardiomyocytes against H/R-induced cytotoxicity dose-dependently by mitochondria-mediated anti-apoptosis pathway. Nicorandil significantly decreased cellular apoptotic rate and enhanced the ratio of Bcl-2/Bax expressions. Further, nicorandil decreased the production of ROS and alleviated calcium overloading in H/R-induced H9c2 cells. In crucial, nicorandil upregulated ACAT1 and OXCT1 protein expressions and either of their gene expressions, contributing to increased production of cellular BHB and ACAC. Nicorandil alleviated cardiomyocytes H/R-induced cytotoxicity through upregulating ACAT1/OXCT1 activity and ketone body metabolism, which might be a potential mechanism for emerging study of nicorandil and other $K_{ATP}$ channel openers.

Infection and Immune Response in the Nematode Caenorhabditis elegans Elicited by the Phytopathogen Xanthomonas

( Yan Ii Bai ),( De Juan Zhi ),( Chan He Li ),( Dong Iing Liu ),( Ju An Zhang ),( Jing Ti An ),( Xin Wang ),( Hui Ren ),( Hong Yu Li ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.9

Xanthomonas oryzae pv. oryzae (Xoo) strains are plant pathogenic bacteria that can cause serious blight of rice, and their virulence towards plant host is complex, making it difficult to be elucidated. Caenorhabditis elegans has been used as a powerful model organism to simplify the host and pathogen system. However, whether the C. elegans is feasible for studying plant pathogens such as Xoo has not been explored. In the present work, we report that Xoo strains PXO99 and JXOIII reduce the lifespan of worms not through acute toxicity, but in an infectious manner; pathogens proliferate and persist in the intestinal lumen to cause marked anterior intestine distension. In addition, Xoo triggers (i) the p38 MAPK signal pathway to upregulate its downstream C17H12.8 expression, and (ii) the DAF-2/DAF-16 pathway to upregulate its downstream gene expressions of mtl-1 and sod-3 under the condition of daf-2 mutation. Our findings suggest that C. elegans can be used as a model to evaluate the virulence of Xoo phytopathogens to host.

Nicorandil alleviated cardiac hypoxia/reoxygenation-induced cytotoxicity via upregulating ketone body metabolism and ACAT1 activity

Yan Ping Bai,Lei Sen Han 대한생리학회-대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.1

Corrigendum to: Nicorandil alleviated cardiac hypoxia/reoxygenation-induced cytotoxicity via upregulating ketone body metabolism and ACAT1 activity

Bai, Yan Ping,Han, Lei Sen The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.3

Decoupling Controller Based on Neural Network

Yan Bai,Guotian Yang,Xingyi Wang 대한전자공학회 1994 ICONIP : International Conference On Neural Inform Vol.3 No.2

Decoupling Controller Based on Neural Networks

Yan Bai,Guotian Yang,Xingyi Wang 대한전자공학회 1994 ICONIP : International Conference On Neural Inform Vol.3 No.1

공사장 가림막의 특성과 시각적 표현 유형의 선호도에 관한 연구

바이옌 ( Bai Yan ),이홍 ( Lee Hong ),안병진 ( Ahn Byoung Jin ) 한국기초조형학회 2018 기초조형학연구 Vol.19 No.2

최근 각 지자체에서는 쾌적한 도시환경 조성을 위하여 도심에서 방치 된 시각적 공해요소로 전락해 온 공사장 가림막에 다양한 디자인적 시도를 통해 도심의 미관을 개선하고자 노력하고 있다. 특히 공사장 가림막에 대한 도시민들의 인식개선을 위해서, 이들이 선호하는 공사장 가림막 디자인은 무엇인지, 그리고 어떠한 유형을 선호하는지에 대하여 살펴볼 필요가 있다. 본 연구는 공사장 가림막 디자인의 인식, 시각적 표현요소와 특성요소에 대한 선호도 차이를 분석한 연구이다. 부산광역시에 거주하는 100명을 대상으로 2017년 6월 9일부터 30일 까지 설문 조사를 실시하였으며, 그중 중복체크 및 피실험자 조건을 성립하지 못하는 10부를 제외한 90부를 분석하였다. 본 연구의 분석 결과 공사장 가림막에 대한 인식은 전체 응답자의 87%가 가림막이 무엇인지에 대하여 알고 있었으며, 특히 연령대가 낮은 여성일수록 공사장 가림막 디자인에 대한 관심이 높은 것으로 조사되었다. 공사장 가림막디자인의 시각적 표현요소는 비대칭 레이아웃과 타이포와 이미지가 혼용된 디자인을, 배경이 있고 난색 위주와 모노 듀오톤의 색채를 선호하는 것으로 조사되었다. 공사장 가림막의 구성 요소 중에서 추상적 이미지와 사진 및 일러스트레이션 이미지가 주를 이루는 디자인을 선호하는 것으로 나타났다. 또한 대부분의 응답자가 공사장 가림막 디자인의 특성요소 중 기능성을 가장 선호하는 것으로 조사 되었다. 본 연구에서 공사장 가림막에 대한 인식, 가림막 디자인의 시각적 표현요소와 특성요소에 대한 선호도를 살펴보았으며, 공사장 가림막에 대한 고정관념과 인식에 대하여 개선하는데 도움이 되고자 하며, 또한 쾌적하고 심미적인 도시환경조성에 있어서 본 연구가 기초자료로 활용되길 희망한다. Recently, local governments try to improve the beauty of the city through various design attempts at construction fence that have become a visual pollution element left unattended in the downtown area to create pleasant urban environments. Especially, to improve the city's perception of construction fence, it is necessary to look at their preferred desing of construction fence, and the type of construction fence they prefer. This study is to analyze the perception of the construction fence, differences of preference of visual expressive elements and Characteristics elements. A questionnaire survey was conducted for 100 people living in Busan Metropolitan City from June 9 to 30, 2017, and 90 copies except for 10 copies which failed duplicate check and test subject condition. Analysis result 87% of respondents know the construction fence, especially the lower age female group be investigated the higher the interest in the design of construction fence. The visual expressive elements of the design of the construction fence prefer the asymmetric layout design and the design which the typography and the image mixed, the background, the warm color and the mono duotone color. Among the components of the construction fence, mainly design preferred which abstract images, photographs and illustration images. Also, most of the respondents were found to prefer the functionality among the characteristics of the design of the construction fence. Finally, this study examined the perception of the construction fence, differences of preference of visual expressive elements and Characteristics elements of the construction fence, It is expected that the result of this study will be useful as a basic data in the design of the construction fence in future.

Normal Estimation for Mass Point Clouds of Irregular Model in the 3D Reconstruction based on Fuzzy Inference

Liu Yan-ju,Jiang Jin-gang,Miao Feng-juan,Tao Bai-rui,Zhang Hong-lie 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.5

This paper presents a fuzzy normal estimate for mass point clouds of irregular models in reconstruction. The irregular model is complex object that some part is smooth and some parts are irregular including sharp features. Therefore, we put kNN and curvature of mass point clouds to fuzzy inference system to divide the kind of point clouds and the output of FIS can determine which part of tooth point clouds belong to. For different kinds point clouds, corresponding algorithm is given. Point clouds in the smooth area are estimated normal by PCA directly and ones in other regions of thin or sharp area are estimated by checker and attach points. This method is simpler than those complex methods used on the whole point clouds directly. The experiment results show that much time is saved and surface reconstruction is very fine than PCA and WLOP.

공공공간 공사장 가림막의 디자인 정보 시각화 유형에 관한 연구

바이옌 ( Bai Yan Design ),서한석 ( Seo Han Sok ),안병진 ( Ahn Byoungjin ) 한국기초조형학회 2017 기초조형학연구 Vol.18 No.2

현대 사회가 도시화(정보화가 진행됨에 따라 도시의 기능과 경관이 발달하고 있으며, 이는 도심에 새로운 공간 형태를 만들고 있다. 이것은 공공문화 이미지 및 디자인 향상 등 도심 환경 개선과 발전에 많은 영향을 미치고 있다. 또한 최근 도심내 공사장 가림막이 다양한 디자인 유형으로 표현되면서 관심이 더욱 커지고 있다. 따라서 본 연구는 공공공간 공사장 가림막의 사례에 관하여 살펴보고, 정보 시각화 특성을 중심으로 국내(국외 도심 내 공공장소에 설치 된 공사장 가림막 디자인의 사례조사들을 비교(분석을 하였다. 사례 선정은 2009년 이후 국내(국외 11개를 선정하였으며, 서울시 공공시설물의 기본 가이드라인에서 정의한 7가지 특성(테마성, 기능성, 심미성, 친환경성, 교류성, 정체성, 보편성)과 정보 시각화 요소를 기준으로 분석하였다. 그 결과, 첫째, 11개 사례 중 8개 사례에서 타이포를 활용하였고, 3개 사례가 오브제 등을 사용하여 다양한 질감을 표현하여 사람들에게 새로운 감각을 선사하고 있는 것으로 나타났다. 둘째, 11개 사례 모두 기능성과 심미성을 가지고 있으며, 그 중 5개 사례가 친환경성, 8개 사례가 테마성, 2개 사례가 교류성, 5개 사례가 정체성을 가지는 것으로 나타났다. 셋째, 정보 시각화 요소의 유형은 전달형, 친환경형, 참여형, 지역형, 아트형으로 나타났으며, 그 중에서 정보 전달형에는 모든 사례가 부합한 것으로 나타났다. 이상으로, 본 연구에서 정보 시각화 요소와 공사장 가림막의 특성을 사례를 중점으로 탐색적으로 살펴보았으며, 그것을 토대로 향후 도심 내 공공공간 공사장 가로환경 개선에 있어서 기초자료를 제시하고자 한다. With the continual urbanization of modern societies, there have been great progress in both the functions and forms of cityscapes. Accordingly, developments in urban spatial methodologies have likewise arisen to cope with these changing times. Consequently, the application of such methodologies have had a significant impact on the development and improvement of urban centers. More recently, there have been an even keener interest and attention on the examinations of fences. Therefore, this study aims to explore the fencing mechanism of urban public spaces as focal points of urban center development, drawing upon multiple case studies for further comparative analysis. In total, eleven national and international case studies have been selected, all of which have been conducted after 2009. Analysis is based on seven core characteristics of the fences: Theme, function, aesthetics, environmentalism, interchangeability, identity, and ubiquity. The results focus on three key points. First, eight of the eleven case studies exhibit design elements that contain letters and characters, while the remaining three primarily have motifs. Second, all eleven case studies demonstrate a focus towards functionality and aesthetics, of which five emphasize on environmentally friendly initiatives, eight are thematic, two indicate interchangeability, and five case studies are holistic. Finally, this paper analyzes these characteristics through informational visualization pertaining to transmission, environmental, participatory, territorial, and artistic models. Serving as a basis for future studies, this paper hopes to perpetuate an interest towards understanding the utilization of fences and its relationship with urban public spaces and urban centers.

Reduction Strategy of Point Clouds to Reconstruct Surface Based on Fuzzy Clustering

Liu Yan-ju,Jiang Jin-gang,Tao Bai-rui,Zhang Hong-lie,Liu Yan-zhong 보안공학연구지원센터(IJGDC) 2014 International Journal of Grid and Distributed Comp Vol.7 No.4