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- 저자 : ( Xinping Song ) (검색결과 2 건)
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( Xinping Song ),( Zijian Zhao ),( Yujuan Zhao ),( Qing Jin ),( Shengyu Li ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.2
Recently, the efficacy of probiotics in treatment of neurodegenerative disorders has been reported in animal and clinical studies. Here, we assessed the effects of Bacillus coagulans JA845 in counteracting the symptoms of D-galactose (D-gal)/AlCl<sub>3</sub>-induced Alzheimer’s disease (AD) in a mice model through behavioral test, histological assessment and biochemical analysis. Ten weeks of pretreatment with B. coagulans JA845 prevented cognitive decline, attenuated hippocampal lesion and protected neuronal integrity, which demonstrated the neuroprotective features of B. coagulans JA845 in vivo. We also found that supplementation of B. coagulans JA845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of D-gal/AlCl<sub>3</sub>-induced AD model mice. Furthermore, B. coagulans JA845 administration attenuated oxidative stress and decreased serum concentration of inflammatory cytokines by regulating the Nrf2/HO-1 and MyD88/TRAF6/NF-κB pathway. Our results demonstrated for the first time that B. coagulans has the potential to help prevent cognitive decline and might be a novel therapeutic approach for the treatment of neurodegenerative diseases.
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A High Step-up DC-DC Converter with Multiplier Voltage Cells
Song Liye,Tian Guosheng,Peng Jishen,Ding Xinping 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
The non-isolated high voltage gain dc-dc converter becomes the focus of research in the sustainable energy converters. This paper proposes a high step-up dc-dc converter with switched-capacitor and 3-winding coupled inductor. It consists of voltage multiplier cell, coupled inductor, and switched-capacitor. Compared with existing high step-up dc-dc converters, the proposed converter incorporates a switched-capacitor at the output side of the converter, which has a lower impulse current and power loss due to the current limiting efect of magnetic element. Therefore, it makes full use of the boosting capability of the switched-capacitor and avoids its drawbacks. The converter achieves high voltage gain by cascaded boost method, which is composed of 3-winding coupled-inductor based boost cells. It reduces voltage stresses on the components in each cell, achieves high voltage gain by utilizing devices with low on-state resistance and low voltage rating that improves the efciency. An inherent passive clamp circuit alleviates voltage spike of switch as well as recycles the leakage energy. The converter provides high voltage gain, high efciency and high power density. The operation modes, steady-state analysis, stresses of the components, comparison with other candidates, and design guideline are analyzed and presented. The validation of the proposed converter is verifed by a 200 W prototype constructed in the laboratory
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