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RISS 인기검색어
- 검색키워드
- 저자 : ( Vincenzo Ziparo ) (검색결과 2 건)
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( Marco La Torre ),( Giuseppe Nigri ),( Annalisa Lo Conte ),( Federica Mazzuca ),( Simone Maria Tierno ),( Adelona Salaj ),( Paolo Marchetti ),( Vincenzo Ziparo ),( Giovanni Ramacciato ) The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.1
Background/Aims: The prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a prognostic indicator of recurrence and reduced overall survival. The aim of this study was to identify preoperative prognostic factors and to create a prognostic model able to assess the early recurrence risk for patients with resectable PAC. Methods: A series of 177 patients with PAC treated surgically at the St. Andrea Hospital of Rome between January 2003 and December 2011 were reviewed retrospectively. Univariate and multivariate analyses were utilized to identify preoperative prognostic indicators. Results: A preoperative CA 19-9 level >228 U/mL, tumor size >3.1 cm, and the presence of pathological preoperative lymph nodes statistically correlated with early recurrence. Together, these three factors predicted the possibility of an early recurrence with 90.4% accuracy. The combination of these three preoperative conditions was identified as an independent parameter for early recurrence based on multivariate analysis (p=0.0314, hazard ratio, 3.9811, 95% confidence interval, 1.1745 to 15.3245). Conclusions: PAC patient candidates for surgical resection should undergo an assessment of early recurrence risk to avoid unnecessary and ineffective resection and to identify patients for whom palliative or alternative treatment may be the treatment of choice. (Gut Liver 2014,8:102-108)
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Elsa Iannicelli,Sara Di Renzo,Mario Ferri,Emanuela Pilozzi,Marco Di Girolamo,Alessandra Sapori,Vincenzo Ziparo,Vincenzo David 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.1
Objective: To evaluate the accuracy of magnetic resonance imaging (MRI) with lumen distention for rectal cancer staging and circumferential resection margin (CRM) involvement prediction. Materials and Methods: Seventy-three patients with primary rectal cancer underwent high-resolution MRI with a phasedarray coil performed using 60-80 mL room air rectal distention, 1-3 weeks before surgery. MRI results were compared to postoperative histopathological findings. The overall MRI T staging accuracy was calculated. CRM involvement prediction and the N staging, the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were assessed for each T stage. The agreement between MRI and histological results was assessed using weighted-kappastatistics. Results: The overall MRI accuracy for T staging was 93.6% (k = 0.85). The accuracy, sensitivity, specificity, PPV and NPV for each T stage were as follows: 91.8%, 86.2%, 95.5%, 92.6% and 91.3% for the group ≤ T2; 90.4%, 94.6%, 86.1%, 87.5% and 94% for T3; 98,6%, 85.7%, 100%, 100% and 98.5% for T4, respectively. The predictive CRM accuracy was 94.5% (k =0.86); the sensitivity, specificity, PPV and NPV were 89.5%, 96.3%, 89.5%, and 96.3% respectively. The N staging accuracy was 68.49% (k = 0.4). Conclusion: MRI performed with rectal lumen distention has proved to be an effective technique both for rectal cancer staging and involved CRM predicting.
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