다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

전립선암과 전립선비대증 환자에서 혈청 유리 및 총전립선특이항원 측정의 의의

서혁준,박형민,권태균,정성광,김법완,이재태 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Purpose: This study was peformed to investigate whether the free to total PSA ratio(F/T PSA ratio) offers a better discriminant for the detection of patient with prostatic cancer(CaP) and those with benign prostatic hyperplasia(BPH) than serum total PSA alone. Materials and Methods: From September 1996 to February 1999, free and total PSA levels were measured on frozen sera samples of 154 men with BPH and 46 with CaP using immunoradiometric assay. Results: In all subjects, the mean total PSA was significantly higher in CaP group(72.57±66.58ng/ml) than BPH group(3.12±4.10ng/ml). The mean PSAD was significantly higher in CaP group(1.64± 1.86) than BPH group(0.08±0.01). The mean F/T PSA ratio was significantly lower in CaP group(0.19± 0.07) than BPH group(0.30±0.13). Among 41 subjects whose total PSA were between 4-20ng/ml, the mean PSAD was significantly higher in CaP group(0.37±7.16) than BPH group(0.17± 0.07), but the mean F/T PSA ratio was not significantly different between CaP(0.19± 0.10) and BPH group(0.25±7.13). By comparing the sensitivity and specificity of total PSA alone, PSAD and F/T PSA ratio on receiver operating characterislic (ROC) Cutie in all subiects and subiects with total PSA between 4-20ng/ml, F/T PSA ratio had no superiority than total PSA alone and PSAD for discrimination between CaP and BPH. Conclusions: We suggest that the F/T PSA ratio is not superior to total PSA alone and FSAD in the detection of prostatic cancer, and further evaluation of the usefulness of F/T PSA ratio should be required.

Phototrichogram findings in alopecia areata and their relation to disease activity and severity

( Chung Hyeok Lee ),( Jong Won Lee ),( Sang Hoon Lee ),( Won-soo Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Phototrichogram is a non-invasive method, which provides an accurate qualitative as well as quantitative assessment of the hair. Furthermore, taking a close-up photograph of a well-defined scalp area can provide sophisticated high-resolution image about scalp, hair shafts and hair follicles. Objectives: Investigate whether hair findings observed in the phototrichogram is related to the activity and severity of alopecia areata. Methods: We retrospectively analyzed 126 patients and 220 AA patches which is taken with a phototrichogram. The magnification of the phototrichogram was 50x to 100x. Using the one-way anova test, correlations between the incidence of each hair findings on phototrichogram and the severity of disease and disease activity were examined Results: A total of 220 AA patches were analyzed. The association between disease severity of AA and clustered white dots (p-value < 0.01, 95% CI: 0.11-0.88) and black dots (p-value < 0.05, 95% CI: 1.13-6.57) showed statistical significance. The association between disease activity of AA and brown dots (p-value< 0.01, 95% CI: 1.10-5.68), exclamation marks hair (p-value <0.05, 95% CI: 1.13-18.27), short vellus hair (p-value < 0.05, 95% CI: 2.11-4.65) and upright regrowth hair (p-value <0.05, 95% CI: 0.35-0.85) showed statistical significance. Conclusion: Phototrichogram findings are related to the activity and severity of alopecia areata.

A case of pityriasis rubra pilaris presenting atypical centripetal spread

( Chung Hyeok Lee ),( Won-soo Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Pityriasis rubra pilaris (PRP) is considered a rare papulosquamous disorder of unknown etiology. PRP manifests with erythematous scaly plaques, typically involving the scalp, trunk and limbs, associated with a yellowish diffuse palmoplantar keratoderma. PRP is classified into six subtypes based on clinical characteristics and courses. Type I PRP (classic adult) is the most common subtype with over 50% of all cases. Characteristically, patients present with an eruption of follicular hyperkeratotic papules that spread in cephalocaudal direction. As the disease further evolves, a reddish orange, scaling dermatitis appears that often progresses to a generalized erythroderma over a period of 2-3 months. A 51-year-old female presented with palmoplantar hyperkeratosis and multiple erythematous follicular papules and patches on her trunk, both arms and legs for 1 years. The skin lesion occurred from the hands and feet first and it spread to arms, legs and trunk. The histopathologic result revealed hyperkeratosis, alternating pattern of ortho- and parakeratosis, acanthosis, follicular plugging and superficial perivascular lymphocytic infiltrates. Based on these clinicopathological findings, the patient was diagnosed with type I PRP. We started a treatment of oral antihistamine, topical corticosteroids, and emollient and the patient showed clinical improvement. Herein, we report an atypical case of type I PRP presenting a centripetal spread.

Biological Evaluation of Tacrolimus as a Therapeutic Drug for Osteopenia

Chung-Hun Oh,Joon-Gu Lee,Hyun-Ju Lim,Man-Seok Bang,Hye-Min Jung,Yea-Jin Lee,Min-Hyeok Lee,Min-Ji Kim,Eun-Young Lee,Sang-Joon Mo,Yun-Hee Rhee,Jang-In Shin 한국실험동물학회 2013 한국실험동물학회 학술발표대회 논문집 Vol.2013 No.8

Long-term Follow up of<i>Helicobacter pylori</i>IgG Serology After Eradication and Reinfection Rate of<i>H. pylori</i>in South Korea

Lee, Jung Hoon,Kim, Nayoung,Chung, Jae Il,Kang, Kyung Phil,Lee, Sang Hyup,Park, Young Soo,Hwang, Jin-Hyeok,Kim, Jin-Wook,Jeong, Sook-Hyang,Lee, Dong Ho,Jung, Hyun Chae,Song, In Sung Wiley (Blackwell Publishing) 2008 HELICOBACTER -CAMBRIDGE USA- Vol.13 No.4

<P>BACKGROUND: Serology is widely used for epidemiologic research of Helicobacter pylori. However, there is limited information on the long-term follow up of H. pylori titers after eradication. In addition, it is presumed that the reinfection rate decreases as the H. pylori infection rate decreases. The aim of this study was to investigate the long-term follow up of H. pylori IgG, and to evaluate the reinfection rate of H. pylori in Korea. METHODS: Among 247 patients, who were enrolled during 2003-07, 185 patients with invasive H. pylori test positive received proton pump inhibitor-based triple therapy, and follow-up H. pylori testing, including histology, CLOtest, culture, and serology, were evaluated 2, 10, and 18 months after H. pylori eradication. RESULTS: The initial H. pylori IgG optical density (OD(450 nm)), 2.06, gradually decreased to 0.63 (67% reduction) at 18 months after H. pylori eradication. The seroreversion rate was 5, 10, and 45% at 2, 10, and 18 months after H. pylori eradication, respectively. The recrudescence of H. pylori was 3.49%, and the annual reinfection rate was 2.94% per year. H. pylori IgG titers abruptly increased in cases with recrudescence and reinfection, and correlated with the results of the invasive H. pylori tests. CONCLUSION: The results of this study showed that H. pylori IgG serology could be used for the determination of reinfection of H. pylori, but not for the diagnosis of H. pylori eradication. The reinfection rate of H. pylori, in Korea, was found to be very low, 2.94% per year.</P>

Efficacy and Safety of Treatment with Fractional 1,064-nm Picosecond Laser with Diffractive Optic Element for Wrinkles and Acne Scars: A Clinical Study

( Chung Hyeok Lee ),( Eun Mi Jin ),( Hee Seok Seo ),( Tae-ui Ryu ),( Seung Phil Hong ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.3

Background: Fractional picosecond lasers is effective for the treatment of wrinkles or acne scars. Objective: To investigate the safety and efficacy of treatment with a fractional 1,064-nm picosecond laser with a diffractive optic element for facial wrinkles and acne scars. Methods: This prospective open-labeled trial comprised 22 subjects with facial wrinkles or acne scars. Subjects received three laser treatments with a fractional 1,064-nm picosecond laser at 3-week intervals. The efficacy and safety were evaluated at every visit and 2 months after the final treatment (14 weeks from the first treatment session). Global photographic assessments were performed by three blinded dermatologists and the subjects. Skin profilometry was performed using three-dimensional digital photographs; viscoelasticity was measured. Results: The overall mean global improvement scores assessed by the dermatologists at weeks 3, 6, and 14, were 1.8±1.46, 2.5±1.88, and 3.5±1.84, respectively, and those assessed by the subjects were 2.7±2.08, 4.1±2.24, and 5.0±2.52, respectively. Skin profilometry showed significant improvements in the skin wrinkles, texture, depressions, and pores. The gross elasticity and skin firmness significantly improved by 10.96% and 9.04%, respectively. The major adverse reactions were erythema, pruritus, and petechiae, which disappeared within 2∼3 days. Conclusion: The fractional 1,064-nm picosecond laser is an effective and safe therapeutic modality for skin rejuvenation. (Ann Dermatol 33(3) 254∼262, 2021)

SEM findings on dentinal micro changes by CO2 Laser irradiation

Hyeok-Jeong Kweon,신승철,조자원,신건철,Chung-Jae Lee,Jung-Yea Lee,Chon-Hee Lee 대한예방치과학회 2007 International Journal of Clinical Preventive Denti Vol.3 No.1

Clinical trial for evaluating the efficacy and safety of laser treatment of fractional 1064-nm picosecond laser on skin rejuvenation

( Chung Hyeok Lee ),( Dong In Keum ),( Seung Phil Hong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Fractional laser technology is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen synthesis and remodeling. Objectives: Investigate whether use of a Fractional treatment with a wavelength 1,064-nm picosecond-domain laser is effective for the treatment of wrinkles and acne scars. Methods: Patients received 3 laser treatments. Laser treatment were performed with a 1064-nm picosecond laser with fractional hand-piece. At 8-week after treatment, the final assessment was performed. Results: Three individual dermatologists compared the blinded pre- and post-treatment photo to assess the clinical improvement. Skin topography and elasticity were measured using Antera 3dTM and CutometerTM respectively. Fifteen women and 7 men (mean age, 39 years; age range, 21-66 years) are enrolled including 12 wrinkle and 10 acne scar patients. There were statistically significant clinical improvements after treatment compared with baseline (3 weeks: 19.1%, p<0.01; 6 weeks: 25.9%, p<0.01; 14 weeks: 35.2%, p<0.01). Skin topography analysis including wrinkle, texture, depression and pores revealed significant improvement compared with the baseline However, skin elasticity showed no significant differences. Post-treatment erythema, mild edema, and petechiae were the only side effects noted. Conclusion: This study revealed the treatment of fractional 1064-nm picosecond laser is an effective way to achieve skin rejuvenation.

Efficacy and safety of treatment with fractional 1064-nm picosecond laser with diffractive optic element for skin rejuvenation: a clinical trial

( Chung Hyeok Lee ),( Seung Phil Hong ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Fractional picosecond lasers is effective for the treatment of wrinkles or acne scars. Objectives: To investigate the safety and efficacy of treatment with a fractional 1064-nm picosecond laser with a diffractive optic element for facial wrinkles and acne scars. Methods: This prospective open-labeled trial comprised 22 subjects with facial wrinkles or acne scars. Subjects received three laser treatments with a fractional 1064-nm picosecond laser at 3-week intervals. The efficacy and safety were evaluated at every visit and 2 months after the final treatment. Global photographic assessments were performed by three blinded dermatologists and the subjects. Skin profilometry was performed using three-dimensional digital photographs; viscoelasticity was measured. Results: The overall mean global improvement scores assessed by the dermatologists at weeks 3, 6 and 14, were 1.8±1.46, 2.5±1.88 and 3.5±1.84, respectively, and those assessed by the subjects were 2.7±2.08, 4.1±2.24, and 5.0±2.52, respectively. Skin profilometry showed significant improvements in the skin wrinkles, texture, depressions, and pores. The gross elasticity and skin firmness significantly improved by 10.96% and 9.04%, respectively. The major adverse reactions were erythema, pruritus, and petechiae, which disappeared within 2-3 days. Conclusion: The fractional 1064-nm picosecond laser is an effective and safe therapeutic modality for skin rejuvenation.