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Zhenhua Wei,Limao Ren,Shibo Song 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.3
3-D reconstruction of industrial flame could be used to research for the completeness of combustion and flame temperature field. As the flame flicks and has no regular evident characteristic, 3-D reconstruction of flame is difficult and lack of study. The paper proposed a stereo matching algorithm for flame based on distance ratio constraint (DRCFMA). Taking flame characteristics into account and using the processed SIFT operates to get the ratio constraint of matched feature points, the algorithm is applied on the follow-up 3-D reconstruction of flame. The results shows the validity and feasibility of DRCFMA. Compared with conventional algorithms, the proposed algorithm has a better accuracy and shorter time-taken for industrial flame. The experiments had shown that the follow-up 3-D reconstruction of flame has clear and continuously changing greyscale layers.
Diversity and complexity of cell death: a historical review
Park Wonyoung,Wei Shibo,Kim Bo-Sung,Kim Bo-Sung,Bae Sung-Jin,Chae Young Chan,Ryu Dongryeol,Ha Ki-Tae 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimental evidence accumulated over the past few decades has revealed different types of cell death that are genetically programmed to eliminate unnecessary or severely damaged cells that may damage surrounding tissues. Several types of cell death, including apoptosis, necrosis, autophagic cell death, and lysosomal cell death, which are classified as programmed cell death, and pyroptosis, necroptosis, and NETosis, which are classified as inflammatory cell death, have been described over the years. Recently, several novel forms of cell death, namely, mitoptosis, paraptosis, immunogenic cell death, entosis, methuosis, parthanatos, ferroptosis, autosis, alkaliptosis, oxeiptosis, cuproptosis, and erebosis, have been discovered and advanced our understanding of cell death and its complexity. In this review, we provide a historical overview of the discovery and characterization of different forms of cell death and highlight their diversity and complexity. We also briefly discuss the regulatory mechanisms underlying each type of cell death and the implications of cell death in various physiological and pathological contexts. This review provides a comprehensive understanding of different mechanisms of cell death that can be leveraged to develop novel therapeutic strategies for various diseases.
Eun-Ju Jin,Shibo Wei,Yunju Jo,Thanh T. Nguyen,Moongi Ji,Man-Jeong Paik,Jee-Heon Jeong,Se Jin Im,유동렬 생화학분자생물학회 2023 BMB Reports Vol.56 No.6
In the present study, to determine the efficacy of oral supplementationof ginseng berry extracts in augmenting exercise performanceand exercise-associated metabolism, male mice weregiven orally 200 and 400 mg/kg of body weight (BW) of GBCfor nine weeks. Although there are no differences in pre-exerciseblood lactate levels among (1) the control group that receivedneither exercise nor GBC, (2) the group that performedonly twice-weekly endurance exercise, and (3) and (4) the groupsthat combined twice-weekly endurance exercise with either200 or 400 mg/kg GBC, statistically significant reductions inpost-exercise blood lactate levels were observed in the groupsthat combined twice-weekly endurance exercise with oral administrationof either 200 or 400 mg/kg GBC. Histologicalanalysis showed no muscle hypertrophy, but transcriptomeanalysis revealed changes in gene sets related to lactate metabolismand mitochondrial function. GBC intake increased nicotinamideadenine dinucleotide levels in the gastrocnemius, possiblyenhancing the mitochondrial electron transport system andlactate metabolism. Further molecular mechanisms are neededto confirm this hypothesis.
Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Nguyen Thanh T.,Wei Shibo,Nguyen Thu Ha,Jo Yunju,Zhang Yan,Park Wonyoung,Gariani Karim,Oh Chang-Myung,Kim Hyeon Ho,Ha Ki-Tae,Park Kyu-Sang,Park Raekil,Lee In-Kyu,Shong Minho,Houtkooper Riekelt H.,Ryu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse cell death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed cell death. Thus, dysfunctional cellular pathways eventually lead or contribute to various age-related diseases, such as neurodegenerative, cardiovascular and metabolic diseases. Thus, mitochondrion-associated programmed cell death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses mitochondrial quality control networks with activity triggered by stimuli and that maintain cellular homeostasis via mitohormesis, the mitochondrial unfolded protein response, and mitophagy. The review also presents details on various forms of mitochondria-associated programmed cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, parthanatos, and paraptosis, and highlights their involvement in age-related disease pathogenesis, collectively suggesting therapeutic directions for further research.
( Seung Min Jeong ),( Eun-ju Jin ),( Shibo Wei ),( Ju-hyeon Bae ),( Yosep Ji ),( Yunju Jo ),( Jee-heon Jeong ),( Se Jin Im ),( Dongryeol Ryu ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.7
This study investigates the relationship between cancer cachexia and the gut microbiota, focusing on the influence of cancer on microbial composition. Lewis lung cancer cell allografts were used to induce cachexia in mice, and body and muscle weight changes were monitored. Fecal samples were collected for targeted metabolomic analysis for short chain fatty acids and micro-biome analysis. The cachexia group exhibited lower alpha diversity and distinct beta diversity in gut microbiota, compared to the control group. Differential abundance analysis revealed higher Bifidobacterium and Romboutsia, but lower Streptococcus abundance in the cachexia group. Additionally, lower proportions of acetate and butyrate were observed in the cachexia group. The study observed that the impact of cancer cachexia on gut microbiota and their generated metabolites was significant, indicating a host-to-gut microbiota axis. [BMB Reports 2023; 56(7): 404-409]
Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy
Ahn Byeong-Yun,Zhang Yan,Wei Shibo,Jeong Yideul,Park Dong-Hyun,Lee Sang-Jin,Leem Young-Eun,Kang Jong-Sun 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of Prmt7 in protecting against menopause-associated cardiomyopathy. Mice with cardiac-specific Prmt7 ablation (cKO) exhibited sex-specific cardiomyopathy. Male cKO mice exhibited impaired cardiac function, myocardial hypertrophy, and interstitial fibrosis associated with increased oxidative stress. Interestingly, female cKO mice predominantly exhibited comparable phenotypes only after menopause or ovariectomy (OVX). Prmt7 inhibition in cardiomyocytes exacerbated doxorubicin (DOX)-induced oxidative stress and DNA double-strand breaks, along with apoptosis-related protein expression. Treatment with 17β-estradiol (E2) attenuated the DOX-induced decrease in Prmt7 expression in cardiomyocytes, and Prmt7 depletion abrogated the protective effect of E2 against DOX-induced cardiotoxicity. Transcriptome analysis of ovariectomized wild-type (WT) or cKO hearts and mechanical analysis of Prmt7-deficient cardiomyocytes demonstrated that Prmt7 is required for the control of the JAK/STAT signaling pathway by regulating the expression of suppressor of cytokine signaling 3 (Socs3), which is a negative feedback inhibitor of the JAK/STAT signaling pathway. These data indicate that Prmt7 has a sex-specific cardioprotective effect by regulating the JAK/STAT signaling pathway and, ultimately, may be a potential therapeutic tool for heart failure treatment depending on sex.