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Lee, Minbaek,Lee, Joohyung,Kim, Tae Hyun,Lee, Hyungwoo,Lee, Byung Yang,Park, June,Jhon, Young Min,Seong, Maeng-Je,Hong, Seunghun IOP Pub 2010 Nanotechnology Vol.21 No.5
<P>Nanoscale sensors based on single-walled carbon nanotube (SWNT) networks have been considered impractical due to several fundamental limitations such as a poor sensitivity and small signal-to-noise ratio. Herein, we present a strategy to overcome these fundamental problems and build highly-sensitive low-noise nanoscale sensors simply by controlling the structure of the SWNT networks. In this strategy, we prepared nanoscale width channels based on aligned SWNT networks using a directed assembly strategy. Significantly, the aligned network-based sensors with narrower channels exhibited even better signal-to-noise ratio than those with wider channels, which is opposite to conventional random network-based sensors. As a proof of concept, we demonstrated 100 nm scale low-noise sensors to detect mercury ions with the detection limit of ∼1 pM, which is superior to any state-of-the-art portable detection system and is below the allowable limit of mercury ions in drinking water set by most government environmental protection agencies. This is the first demonstration of 100 nm scale low-noise sensors based on SWNT networks. Considering the increased interests in high-density sensor arrays for healthcare and environmental protection, our strategy should have a significant impact on various industrial applications. </P>
Lee, Byung Yang,Seo, Sung Min,Lee, Dong Joon,Lee, Minbaek,Lee, Joohyung,Cheon, Jun-Ho,Cho, Eunju,Lee, Hyunjoong,Chung, In-Young,Park, Young June,Kim, Suhwan,Hong, Seunghun Royal Society of Chemistry 2010 Lab on a chip Vol.10 No.7
<P>We developed a carbon nanotube (CNT)-based biosensor <I>system</I>-<I>on</I>-<I>a</I>-<I>chip</I> (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as <I>efficient signal processing</I>, <I>uniform CNT networks</I>, and <I>biocompatible functionalization of CNT</I>-<I>based sensors</I>. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.</P> <P>Graphic Abstract</P><P>Uniform arrays of carbon nanotube (CNT)-based biosensors were integrated with CMOS signal-processing circuits into a CNT-biosensor system-on-a-chip (SoC) for the detection of glutamate, a neurotransmitter. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b916975j'> </P>
Lee, Seunghun,Ji, Kwang-sun,Park, Hyomin,Tark, Sung Ju,Park, Sungeun,Lee, Jeong Chul,Kim, Won Mok,Kang, Yoonmook,Lee, Hae-Seok,Kim, Donghwan Elsevier 2015 THIN SOLID FILMS - Vol.589 No.-
<P><B>Abstract</B></P> <P>We investigated the structural, optical, and electrical properties of Zn–In–Sn–O (ZITO) films prepared by RF magnetron sputtering for silicon heterojunction solar cells. The effects of Zn addition on the properties of the as-grown films were examined. XRD patterns of the ZITO films deposited at room temperature showed a broad peak. The cross-sectional TEM image of ZITO films at low Zn levels exhibited a typical fine or nanostructure embedded in an amorphous phase. On the other hand, at higher Zn addition, the films exhibited a completely amorphous phase. The carrier concentration decreased with increasing Zn content. The lowest electrical resistivity of 5.5×10<SUP>-4</SUP> Ωcm was observed for a ZITO film with 4.83 Znat.%. All ZITO films grown in this study showed transmittance of over 80% in the visible and near-infrared spectral range. The absorption was less than 5% in the visible region.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Zn–In–Sn–O(ZITO) films with various Zn and Sn contents prepared by RF magnetron sputtering </LI> <LI> Some ZITO films exhibited nanocrystalline structures embedded in an amorphous phase. </LI> <LI> The electrical and optical properties improved with increasing Zn content. </LI> </UL> </P>
Lee, Seungwon,Kim, Hyekang,You, Gihoon,Kim, Young-Min,Lee, Seunghun,Le, Viet-Hoan,Kwon, Ohseop,Im, Sin-Hyeog,Kim, You-Me,Kim, Kwang Soon,Sung, Young Chul,Kim, Ki Hean,Surh, Charles D.,Park, Yunji,Lee, American Society of Hematology 2019 Blood Vol.134 No.16
<B>Abstract</B><P>Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors.</P>
Seunghun J. Lee,Gaku Kurita,Jeremy Perkins 서울대학교 외국어교육연구소 2018 외국어교육연구 Vol.22 No.-
Chinese L2 learners of Japanese are identified as showing difficulties in the production of Japanese geminates. The idea of being difficult-to-listen is embodied in the concept Comprehensibility (Derwing & Munro 2015). This study first reviews the native pronunciation of Japanese singleton vs. geminate contrast. Then, we report findings based on the pronunciation by 20 Chinese learners of Japanese and discuss the issue of comprehensibility in geminate production. While the contrast in the closure duration between singleton and geminate consonants shows a similar pattern to reported Japanese speech, the learners show large differences in the vowel duration preceding and following consonants. We report findings from a linear mixed model that was run with speaker as a random effect. The results show that participants do not make differences in vowel duration, or the difference in vowel duration is reversed from L1 Japanese speakers. Identifying the locus of the source of an L2 accent should be accompanied with intelligibility and comprehensibility. Such identification is important in increasing comprehensibility in speech that is already intelligible.
( Seunghun LEE ),( Ju Han KIM ),( Myung Ho JEONG ),( Hyukjin PARK ),( Ji Eun KIM ),( Youngkeun AHN ),( Jong Hyun KIM ),( Shung Chull CHAE ),( Young Jo KIM ),( Seung Ho HUR ),( In Whan SEONG ),( Take J 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: This study aims to investigate clinical features, angiographic fi ndings, and outcomes of young AMI patients. Methods: We analyzed major adverse cardiac events (MACE) in the Korea Acute Myocardial Infarction Registry from November 2005 to October 2010. Registered patients were divided into two groups, young age group (<45 years) and old age group (=65 years). Results: Young age group was composed of 1,248 patients (39.6±4.3 years) and old age group 9,759 patients (74.5±6.5 years). Male, smoking, family history and dyslipidemia were more frequent in young age group than those in old age group (96.6% vs. 57.5%, P<0.001; 86.9% vs. 45.7%, P<0.001; 15.5% vs. 4.8%, P<0.001; 13.4% vs. 9.5%, P<0.001). Young Korean adults with AMI had a shorter symptom-to-door (17.4±72.6 min vs. 24.2±77.7 min, P=0.002), but a longer door-to-balloon time (111.1±106.8 min vs. 101.8±92 min, P=0.043). The young age group had shown a favorable prognosis compared with old age group by Kaplan-Meier survival analysis (long-rank, P<0.001). However, there was no signifi cant difference in the adjusted MACE rate at one-year (HR 1.10, 95% CI 0.79-1.53, P=0.585), even after propensity-matched analysis (HR 0.80, 95% CI 0.52-1.23, P=0.307). Conclusions: Young Korean adults with AMI have similar clinical outcomes with old age patients, and therefore they should be treated aggressively like elderly patients.
Linear Ion Beam Applications for Roll-to-Roll Metal Thin Film Coatings on PET Substrates
Seunghun Lee,Do-Geun Kim 한국진공학회(ASCT) 2015 Applied Science and Convergence Technology Vol.24 No.5
Linear ion beams have been introduced for the ion beam treatments of flexible substrates in roll-to-roll web coating systems. Anode layer linear ion sources (300 mm width) were used to make the linear ion beams. Oxygen ion beams having an ion energy from 200 eV to 800 eV used for the adhesion improvement of Cu thin films on PET substrates. The Cu thin films deposited by a conventional magnetron sputtering on the oxygen ion beam treated PET substrates showed Class 5 adhesion defined by ASTM D3359-97 (tape test). Argon ion beams with 1∼3 keV used for the ion beam sputtering deposition process, which aims to control the initial layer before the magnetron sputtering deposition. When the discharge power of the linear ion source is 1.2 kW, static deposition rate of Cu and Ni were 7.4 and 3.5 A/sec, respectively.