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        Role of regular physical activity in modifying cardiovascular disease risk factors among elderly Korean women

        ( Seunghui Baek ),( Lorraine S. Evangelista ),( Youngmee Kim ) 한국스포츠정책과학원(구 한국스포츠개발원) 2018 International Journal of Applied Sports Sciences Vol.30 No.1

        Introduction: This study examined physical activity (PA) participation rates and the role of PA in the modification of cardiovascular disease (CVD) risk factors according to types of PA in elderly Korean women using data from 2007 to 2012 from a nationally representative South Korean database.Materials and Method: In total, 3,456 elderly women aged ≥65 years, without CVD, were included in the study. CVD risk was evaluated using both the 10-year Framingham risk score (FRS) and atherogenic index (AI), as well as well-known CVD risk factors such as hypertension, diabetes mellitus, smoking, and hypercholesterolemia.Results: The PA participation rates were 4.7%, 33.9%, and 61.4% for the regular PA, regular walking, and no PA groups, respectively. Multiple linear regression analyses revealed that regular PA and regular walking were associated with a favorable lipid profile and lower AI, after controlling for socio-demographic factors and types of PA. PA did not significantly affect the FRS.Conclusion: This study suggests that regular PA and walking are important in the modification of CVD risk factors among elderly Korean women.

      • KCI등재후보

        한국노인운동의 키워드 네트워크 분석을 통한 연구동향 (1995~2019년)

        백승희 ( Baek Seunghui ),김은정 ( Kim Eunjung ) 대한체육학회(구 한국유산소운동과학회) 2021 대한스포츠융합학회지 (jcses) Vol.19 No.1

        The study aims to identify the research trend centered on keywords most frequently used in research on elderly citizens with the topic of exercise based on domestic academic journals published. Keyword network analysis based on network algorithm was used. For the network text analysis, the SNA package of the R program(version 3.5.3) was adopted to extract major keywords based on the frequency and to identify the connectivity between them. As a result, it turned out that the number of research on senior exercise has been steadily increasing since 1995. Major keywords used were: “elderly”-562 times(28.3%), “elderly women”-377 times(19.0%), “exercise”-281 times(14.1%), “body composition”-159 times(8.0%), “combine exercise”- 143 times(7.2%), “physical fitness”-122 times(6.1%), “balance”-107 times(5.4%), “depression”- 99 times(5.0%), “lipid”-99 times(5.0%), and “resistance exercise”-88 times(4.4%). Also, the result was reanalyzed based on the four major diseases seniors develop gotten from the keyword network analysis. Among the 331 thesis papers on obesity, 48.0% included the keyword “body composition,” 6.9% included “BMI,” 4.2% included “body fat,” and 3.9% included “% body fat.” Also, among the 285 papers on falls, 26.7% included “gait ability,” 24.2% included “fall,” and 18.6% included “BMD.” Among the 218 papers on depression, 45.4% included the keyword “depression,” 33.9% included “QOL,” 20.64% included “self-efficacy,” 9.2% included “self-esteem,” and 7.34% included “life satisfaction.” Meanwhile, among 126 thesis papers on dementia, 17.5% included the keyword “cognitive function,” 13.5% included “BDNF,” and 6.3% included “MMSE-K”. This result of keyword network analysis will be able to serve as the primary data for researchers studying the exercise of aged citizens when establishing an academic system. Also, by emphasizing the importance of elderly workouts, it will be able to work as a bridgehead for policy support in a bid to make the exercising habit a part of their daily life, and ultimately contribute to the development of physical training.

      • KCI등재

        한국 청소년의 비만수준과 상대악력의 연관성

        백승희 ( Baek Seunghui ),신지은 ( Shin Jieun ) 대한체육학회 2021 대한스포츠융합학회지 (jcses) Vol.19 No.2

        The study aims to examine the correlation between the Bady max index(BMI) as one of an obesity index andthe grip strength of Korean adolescents. Among the adolescents aged 12-18 years from the 2016-2019 National Health and Nutrition ExaminationSurvey (KNHANES), 1,032 males and 950 females were selected as final subjects, excluding subjects whoseheight, weight, and grip strength were not investigated or measured. All statistical analysis used SAS 9.4, andcomplex sample analysis was conducted using weights based on the guidelines for using raw data from the KNHANES.First, relative grip strength was divided into quartiles and the differences between groups wereanalyzed using a general linear model (GLM). Then, the relationship between waist circumference and relativegrip strength according to the BMI percentile level of children and adolescents was analyzed throughregression analysis. As a result, the basic characteristics were analyzed by mean and standard error, frequency and percentage (%), and tested through general linear model (GLM) and crossover analysis (Rao-Scott x2). Second, regression analysis was used to determine the relationship between obesity and relative grip strength according to the level of obesity, and the relationship between obesity and relative grip strength was analyzed by adjusting for age. The differences in BMI, weight, height, and relative grip strength were all significantly higher in males according to gender, and in the relationship between obesity and relative grip strength, both male and female adolescents with normal and obese weights, the higher the relative grip strength, the higher the BMI. was significantly lowered. The results of this study are expected to serve as important basic data fordetermining the health status of adolescents, and furthermore, it can give you the motivation to improve your physical fitness by being aware of your physical fitness level. And, it is expected that it can be used as an index to manage the health of students in the school field.

      • Identification of tumor suppressor miRNAs by integrative miRNA and mRNA sequencing of matched tumor–normal samples in lung adenocarcinoma

        Yu, Namhee,Yong, Seunghui,Kim, Hong Kwan,Choi, Yoon‐,La,Jung, Yeonjoo,Kim, Doyeon,Seo, Jihae,Lee, Ye Eun,Baek, Daehyun,Lee, Jinseon,Lee, Seungjae,Lee, Jong Eun,Kim, Jaesang,Kim, Jhingook,Lee, Sa John Wiley and Sons Inc. 2019 MOLECULAR ONCOLOGY Vol.13 No.6

        <P>The roles of miRNAs in lung cancer have not yet been explored systematically at the genome scale despite their important regulatory functions. Here, we report an integrative analysis of miRNA and mRNA sequencing data for matched tumor–normal samples from 109 Korean female patients with non‐small‐cell lung adenocarcinoma (LUAD). We produced miRNA sequencing (miRNA‐Seq) and RNA‐Seq data for 48 patients and RNA‐Seq data for 61 additional patients. Subsequent differential expression analysis with stringent criteria yielded 44 miRNAs and 2322 genes. Integrative gene set analysis of the differentially expressed miRNAs and genes using miRNA–target information revealed several regulatory processes related to the cell cycle that were targeted by tumor suppressor miRNAs (TSmiR). We performed colony formation assays in A549 and NCI‐H460 cell lines to test the tumor‐suppressive activity of downregulated miRNAs in cancer and identified 7 novel TSmiRs (miR‐144‐5p, miR‐218‐1‐3p, miR‐223‐3p, miR‐27a‐5p, miR‐30a‐3p, miR‐30c‐2‐3p, miR‐338‐5p). Two miRNAs, miR‐30a‐3p and miR‐30c‐2‐3p, showed differential survival characteristics in the Tumor Cancer Genome Atlas (TCGA) LUAD patient cohort indicating their prognostic value. Finally, we identified a network cluster of miRNAs and target genes that could be responsible for cell cycle regulation. Our study not only provides a dataset of miRNA as well as mRNA sequencing from the matched tumor–normal samples, but also reports several novel TSmiRs that could potentially be developed into prognostic biomarkers or therapeutic RNA drugs.</P>

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