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김서윤(Kim, Seoyun),양진향(Yang, Jinhyang) 한국간호교육학회 2015 한국간호교육학회지 Vol.21 No.3
Purpose: Patients on hemodialysis need to manage the stress of having a life-threatening condition. The purpose of this study was to identify factors associated with stress among patients on hemodialysis. Methods: The research had a cross-sectional, descriptive design using a questionnaire. The participants were 91 adult patients on hemodialysis from four dialysis centers in a large Korean city. Data were analyzed with the SAS 9.2 program using descriptive statistics, t-tests, ANOVA, and multiple regression. Results: There were statistically significant differences in stress by age, dialysis period, and change in employment status. In hemodialysis patients, stress was significantly positive correlated with fatigue and depression, but negatively correlated with self-esteem. Stepwise multiple regression analysis for stress revealed that the most powerful predictor was depression. Depression and fatigue explained 32.5% of the variance. Conclusion: The results indicate a need to manage the stress of these patients. The findings also suggest that consideration be given to characteristics of age, dialysis period, and employment status in developing strategies to reduce depression and fatigue and developing programs to manage the stress of patients on hemodialysis.
북한이탈 여성의 자궁경부암에 대한 인식 : 포커스그룹 면담
김진현(Jinhyun Kim),양진주(Jinju Yang),최서연(Seoyun Choi),정재원(ChaeWeon Chung) 다문화건강학회 2022 다문화건강학회지 Vol.12 No.1
Purpose: This study explored the perceptions of cervical cancer among female defectors from North Korea. Methods: Aqualitative method using focus group interviews was employed. Thirteen participants who were older than 20 when theyleft North Korea were recruited through a church-based community in Seoul. Data were collected from 3 focus group in terviews conducted in July 2021 after obtaining written consent from each participant. Each interview lasted for 40 to 50minutes and was recorded. After verbatim transcription, the data were analyzed qualitatively using the conventional con tent analysis method. Results: The following four categories were identified, each with two to three subcategories: mis conceptions about cervical cancer, barriers to knowledge acquisition, negative emotions toward the screening test, andexpectations for cervical cancer education. Conclusion: North Korean defectors have been considered particularly vulner able to cervical cancer, a major women’s health issue. Education and healthcare services need to be integrated into theservices they receive after they enter South Korea.
CD160 is essential for NK-mediated IFN-γ production
Tu, Tony C.,Brown, Nicholas K.,Kim, Tae-Jin,Wroblewska, Joanna,Yang, Xuanming,Guo, Xiaohuan,Lee, Seoyun Hyunji,Kumar, Vinay,Lee, Kyung-Mi,Fu, Yang-Xin The Rockefeller University Press 2015 The Journal of experimental medicine Vol.212 No.3
<P>NK-derived cytokines play important roles for natural killer (NK) function, but how the cytokines are regulated is poorly understood. CD160 is expressed on activated NK or T cells in humans but its function is unknown. We generated CD160-deficient mice to probe its function. Although CD160<SUP>−/−</SUP> mice showed no abnormalities in lymphocyte development, the control of NK-sensitive tumors was severely compromised in CD160<SUP>−/−</SUP> mice. Surprisingly, the cytotoxicity of NK cells was not impaired, but interferon-γ (IFN-γ) secretion by NK cells was markedly reduced in CD160<SUP>−/−</SUP> mice. Functionally targeting CD160 signaling with a soluble CD160-Ig also impaired tumor control and IFN-γ production, suggesting an active role of CD160 signaling. Using reciprocal bone marrow transfer and cell culture, we have identified the intrinsic role of CD160 on NK cells, as well as its receptor on non-NK cells, for regulating cytokine production. To demonstrate sufficiency of the CD160<SUP>+</SUP> NK cell subset in controlling NK-dependent tumor growth, intratumoral transfer of the CD160<SUP>+</SUP> NK fraction led to tumor regression in CD160<SUP>−/−</SUP> tumor-bearing mice, indicating demonstrable therapeutic potential for controlling early tumors. Therefore, CD160 is not only an important biomarker but also functionally controls cytokine production by NK cells.</P>