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( Seongjae Kim ),( Hyeoung-eun Kim ),( Boyeon Kang ),( Youn-woo Lee ),( Hangeun Kim ),( Dae Kyun Chung ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.10
Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is recognized by Toll-like receptor 2, expressed on certain mammalian cell surfaces, initiating signaling cascades that include nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase. There are many structural and functional varieties of LTA, which vary according to the different species of gram-positive bacteria that produce them. In this study, we examined whether LTA isolated from Staphylococcus aureus (aLTA) affects the expression of junction proteins in keratinocytes. In HaCaT cells, tight junctionrelated gene expression was not affected by aLTA, whereas adherens junction-related gene expression was modified. High doses of aLTA induced the phosphorylation of extracellular signal-regulated protein kinases 1 and 2, which in turn induced the epithelial-mesenchymal transition (EMT) of HaCaT cells. When cells were given a low dose of aLTA, however, NF-κB was activated and the total cell population increased. Taken together, our study suggests that LTA from S. aureus infections in the skin may contribute both to the outbreak of EMT-mediated carcinogenesis and to the genesis of wound healing in a dose-dependent manner.
안소윤,안성자,권해연,Ahn, So Youn,An, SeongJa,Kwon, HaeYeon 대한물리치료과학회 2014 대한물리치료과학회지 Vol.21 No.1
Background : This study aims to examine actual conditions of college students' life, behaviors to prepare for employment, and employment performance, thereby providing basic materials to create efficient measures for college students' employment strategies. Method : The subjects of this study were 207 graduates from the Department of Physical Therapy employed in medical and health institutions in Gyeongsangnam-do and Busan. Aquestionnaire devised by Yu Yeon-wha and Lim Gyeong-ae(2012, 2011) was revised and complemented into a self-reporting questionnaire composed of 29 questions. The collected data was analyzed using SPSS Win 18.00 program. Results : 1) The biggest reason for the respondents' selecting physical therapy as a major was bright prospect for employment, and the largest percent of the respondents answered that they started to prepare for employment in the second semester of junior year. 2)Regarding behaviors to prepare for employment, those who largely provided information on employment were the respondents' seniors and friends. 62.3% of the respondents owned certificates and diplomas. 59.9% took part in programs related to employment in order to prepare for employment. Their weakest area was English and what they wanted to know most was annual salaries provided by companies. They put self-development and growth potential before everything as what should be considered in priority when getting a job. 3)The most frequently asked question in their interviews for employment was the motive for application. The biggest reason for their employment at their current institution was their good personality and manner. 4)As for employment performance, they were unsatisfied with their current average annual salary. Conclusion : School should provide consciousness education and employment coaching so that students can early prepare for employment with an active attitude. In particular, educational environment where many students can gain easy access to information about employment in diverse areas should be provided and student coaching should be actively conducted.
Hong, Yi-Fan,Lee, Yoon-Doo,Park, Jae-Yeon,Kim, Seongjae,Lee, Youn-Woo,Jeon, Boram,Jagdish, Deepa,Kim, Hangeun,Chung, Dae Kyun The Korean Society for Microbiology and Biotechnol 2016 Journal of microbiology and biotechnology Vol.26 No.7
Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heat-killed W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.
( Yi-fan Hong ),( Yoon-doo Lee ),( Jae-yeon Park ),( Seongjae Kim ),( Youn-woo Lee ),( Boram Jeon ),( Deepa Jagdish ),( Hangeun Kim ),( Dae Kyun Chung ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heatkilled W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappalight-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun Nterminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.