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A Study of the Endocrine Disrupting Activity of Phthalate Esters using Human Cancer Cell Lines
Han, Sang-Kuk 木浦海洋大學校 2002 論文集 Vol.10 No.1
Phthalate esters have recently been added to the list of chemicals which mimic the female hormone estrogen. However, they have been tested for estrogenic activity only to a very small extent. In this study, therefore, we test to estrogenic and androgenic agonists and antagonists of phthalate esters by E-Screen and A-Screen bioassay. In the E-Screen assay, butylbenzyl phthalate (BBP), di-n-butyl phthalate (DBP), diethyl phthalate (DEP), and di-2-ethylhexyl phthalate (DEHP) showed all weakly estrogenic activity, comparing with β-estradiol-17-acetate (E₂) as positive control. Also, all of them stimulated maximally the proliferation of MCF-7 cells at a concentration of 10 μM. Other phthalate esters tested not showed estrogenic activity. In the A-Screen assay, all of phthalate esters tested showed no androgen agonistic activity. However, BBP and DBP were antiandrogenics in the antagonist assay. Our results demonstrate that hormone mimicking chemicals can have multiple hormonal activities, which may make it difficult to interpret their mechanisms of action in vivo.
Han, Yeon-Hee,Lim, Seok-Tae,Yun, Kuk-No,Yim, Sung-Kyun,Kim, Dong-Wook,Jeong, Hwan-Jeong,Sohn, Myung-Hee The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.2
Purpose : An elevated thyroid stimulating hormone level (TSH) is essential to stimulate the uptake of radioiodine into thyroid remnants andmetastases of thyroid cancer when a patient undergoes high-dose radioiodine therapy. Nowadays, recombinant human thyroid stimulating hormone (rh-TSH) is increasingly used instead of the classic method of thyroid hormone withdrawal (THW). However, beyond the therapeutic effects, clinical differences between the two methods have not yet been clearly demonstrated. The aim of this work was to investigate the effects of the two methods, especially on liver function. Methods : We identified 143 evaluable patientswho were further divided into two groups: THW and rh-TSH. We first reviewed the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, which were measured during the admission period for total thyroidectomy. We called these liver enzyme levels "base AST" and "base ALT." We also assessed other chemistry profiles, including AST, ALT, total cholesterol, LDL cholesterol, alkaline phosphatase (ALP), total bilirubin (TB), and triglyceride (TG), which were measured on admission day for high-dose radioiodine therapy. We called these liver enzyme levels "follow-up AST" and "follow-up ALT." We compared the changes in base and follow-up liver enzyme levels and the other chemistry profiles between the two groups. Results : The base AST and base ALT levels of the two groups were within normal range, and there was no significant difference between the two groups. In contrast to these base liver enzyme levels, follow-up liver enzyme levels between the two groups showed significant differences. Patients in the THW group had higher follow-up AST and ALT levels than did the rh-TSH group. Patients in the THW group also had higher levels of total cholesterol and LDL cholesterol than did the patients in the rh-TSH group. However there were no statistically significant differences in ALP, total bilirubin, and triglyceride levels between the two groups. Conclusions : In this retrospective analysis of liver function, the use of rh-TSH for high-dose radioiodine therapy had less of an effect on liver function and cholesterol levels than dose thyroid hormone withdrawal. This suggests that rh-TSH can be used effectively and safely especially for patients with metabolic syndrome.
Chironomidae (Diptera) Fauna of Seoul-Gyeonggi Area in Korea
( Kuk Bon Na ),( Han Il Ree ),( Sang Woo Jung ),( Yeon Jae Bae ) 고려대학교 한국곤충연구소 2010 昆蟲硏究誌 Vol.26 No.-
The Chironomidae (Diptera) fauna of the Seoul-Gyeonggi area in Korea was investigated during 2003-2004. As a result, 41 species in 23 genera and 4 subfamilies including 19 new Korean records, as follows, were identified: Microtendipes tamaogouti Sasa, Microtendipes truncatus Kawai and Sasa, Paracladopelma tamahikawai Sasa, Polypedilum pedestre (Meigen), Stictochironomus sp., Micropsectra shouharasima Sasa, Neozavrelia bicoliocula (Tokunaga), Rheotanytarsus tamaquartus Sasa, Tanytarsus tamaoctavus Sasa, Tanytarsus sp., Euryhapsis subviridis (Siebert), Paratrichocladius rufiventris (Meigen), Conchapelopia quatuormaculata Fittkau, Conchapelopia sp.1, Conchapelopia sp.2, Rheopelopia maculipennis (Zetterstedt), Trissopelopia longimana (Staeger), Potthastia gaedii (Meigen), and Potthastia montium (Edward). List of species was provided with bibliographic sources and material data.
Sung Soo Kim,Hyun Kuk Kim,Hyung Wook Park,Myung Ho Jeong,임경섭,Hae Jin Kee,Yu Hee Ryu,Han Byul Kim,Joo-Young Na,Young-Jae Ki,Keun-Ho Park,Dong-Hyun Choi,Ki Hong Lee,Nam Sik Yoon,Jeong Gwan Cho 대한심장학회 2020 Korean Circulation Journal Vol.50 No.1
Background and Objectives: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular arrhythmia (VA) after AMI in a porcine model. Methods: Twenty pigs were randomly divided into 2 groups based on RDN (RDN, n=10; Sham, n=10). After implanting a loop recorder, AMI was induced by occlusion of the middle left anterior descending coronary artery. Catheter-based RDN was performed for each renal artery immediately after creating AMI. Sham procedure used the same method, but a radiofrequency current was not delivered. Electrocardiography was monitored for 1 hour to observe VA. One week later, the animals were euthanized and the loop recorder data were analyzed. Results: Ventricular fibrillation event rate and the interval from AMI creation to first VA in acute phase were not different between the 2 groups. However, the incidence of premature ventricular complex (PVC) was lower in the RDN than in the Sham. Additionally, RDN inhibited prolongation of the corrected QT (QTc) interval after AMI. The frequency of non-sustained or sustained ventricular tachycardia, arrhythmic death was lower in the RDN group in the early period. Conclusions: RDN reduced the incidence of PVC, inhibited prolongation of the QTc interval, and reduced VA in the early period following an AMI. These results suggest that RDN might be a therapeutic option in patients with electrical instability after AMI.