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Jeong, Sung In,Burns, Nancy A.,Bonino, Christopher A.,Kwon, Il Keun,Khan, Saad A.,Alsberg, Eben The Royal Society of Chemistry 2014 Journal of Materials Chemistry B Vol.2 No.46
<P>A significant problem affecting electrospun nanofibrous tissue scaffolds is poor infiltration of cells into their three-dimensional (3D) structure. Environmental and physical manipulation, however, can enhance cellular infiltration into electrospun scaffolds. In this work, RGD-modified alginate mats with increased thickness and porosity were achieved by pairing high humidity electrospinning with post-processing ultra-sonication. RGD-modified alginate, polyethylene oxide (PEO), and an FDA-approved, nonionic surfactant blends were electrospun in 20 and 50% relative humidity conditions. Mats electrospun in high humidity conditions resulted in significantly increased mat thickness and decreased fiber diameters. The mats' alginate content was then isolated <I>via</I> ionic crosslinking and PEO/surfactant extraction. Finally, the alginate-only mat was post-processed by ultra-sonication to further enhance its cross-sectional thickness. Cell morphology, proliferation, and infiltration into the scaffolds were evaluated by seeding fibroblasts onto the alginate mat. Cell spreading, growth and infiltration improved with increased humidity and ultra-sonication. This approach shows great promise for the design of cell-permeable nanofibrous scaffolds for tissue-engineering applications.</P>
Abdullah A. Saad,Wasi Khan,Pooja Dhiman,A. H. Naqvi,M. Singh,유춘리 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.1
Nanoparticles (NPs) of (La1-xSrx)(Fe1-xNix)O3, (x = 0.0, 0.1 & 0.2) with orthorhombic perovskite structure was successfully prepared through the sol-gel combustion method. The structural, optical and magnetic properties of the NPs were studied by x-ray diffraction (XRD), scanning electron microscopy (SEM) equipped with an energy dispersive x-ray spectrometer (EDS), UV-Vis. Spectrometer and magnetization measurements. The crystallite size was estimated from x-ray diffraction (XRD) patterns, which decreases with increase in Sr and Ni contents and SEM images exhibit formation of agglomerated NPs for pure and doped samples. The absorbance has a tendency to increase with the increase in dopant concentration and band gap increases with Sr and Ni contents. Magnetization measurement revealed ferromagnetic nature of all samples at room temperature.
( Austin J. Peters ),( Saad A. Khan ),( Seiji Koike ),( Susan Rowell ),( Martin Schreiber ) 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.4
Purpose: Ketamine has historically been contraindicated in traumatic brain injury (TBI) due to concern for raising intracranial pressure. However, it is increasingly being used in TBI due to the favorable respiratory and hemodynamic properties. To date, no studies have evaluated whether ketamine administered in subjects with TBI is associated with patient survival or disability. Methods: We performed a retrospective analysis of data from the multicenter Prehospital Tranexamic Acid Use for Traumatic Brain Injury trial, comparing ketamine-exposed and ketamine-unexposed TBI subjects to determine whether an association exists between ketamine administration and mortality, as well as secondary outcome measures. Results: We analyzed 841 eligible subjects from the original study, of which 131 (15.5%) received ketamine. Ketamine-exposed subjects were younger (37.3±16.9 years vs. 42.0±18.6 years, P=0.037), had a worse initial Glasgow Coma Scale score (7±3 vs. 8±4, P=0.003), and were more likely to be intubated than ketamine-unexposed subjects (88.5% vs. 44.2%, P<0.001). Overall, there was no difference in mortality (12.2% vs. 15.5%, P=0.391) or disability measures between groups. Ketamine-exposed subjects had significantly fewer instances of elevated intracranial pressure (ICP) compared to ketamine-unexposed subjects (56.3% vs. 82.3%, P=0.048). In the very rare outcomes of cardiac events and seizure activity, seizure activity was statistically more likely in ketamine-exposed subjects (3.1% vs. 1.0%, P=0.010). In the intracranial hemorrhage subgroup, cardiac events were more likely in ketamine-exposed subjects (2.3% vs. 0.2%, P=0.025). Ketamine exposure was associated with a smaller increase in TBI protein biomarker concentrations. Conclusions: Ketamine administration was not associated with worse survival or disability despite being administered to more severely injured subjects. Ketamine exposure was associated with reduced elevations of ICP, more instances of seizure activity, and lower concentrations of TBI protein biomarkers.
Prabhu, Shamit S.,Khan, Saad A.,Doudnikoff, Alexander L.,Reebye, Uday N. The Korean Dental Society of Anesthsiology 2019 Journal of Dental Anesthesia and Pain Medicine Vol.19 No.1
Myasthenia gravis (MG) is a neuromuscular autoimmune disorder which clinically presents as muscular weakness and fatigue due to autoantibody formation against acetylcholine receptors (AChR), leading to their subsequent destruction. Due to the neuromuscular implications of MG, certain considerations must be taken into account when providing anesthesia to MG patients. In the following case report, we have outlined procedural considerations for the anesthetic management of a patient with MG undergoing deep sedation for an elective oral surgery in an outpatient setting, as well as a discussion of relevant literature.
황장선,손재우,서영민,조연호,이경우,이도현,Muhammad Saad Khan,Sachin Chavan,박찬휘,Anand Sharma,Assaf A. Gilad,최종훈 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-
Bacterial infections and resistance against antibiotics are on the rise despite new drug development. New developments in the field of nanomedicine are proving to be an alternative for traditional antibiotics. Silica nanoparticles (SiNPs) have a promising role in emerging nanomedicine because of their low cytotoxicity and efficient drug delivery potential. In current study, we developed and analyzed silica nanoparticles of ∼50 nm in size that are capable of encapsulating small organic molecules and drugs, such as fluorescein isothiocyanate (FITC), doxorubicin (DOX), 4′, 6-diamidino-2-phenylindole (DAPI) and/or isoniazid (INH). Our drug delivery contains the anti-tuberculosis drug, INH, which is encapsulated in beta (β)-glucan-conjugated SiNPs. We focused on synthesizing and encapsulating SiNPs that have amine functional groups as well as the ability to conjugate with β-glucan molecules, making the nanocomplex both a drug carrier and a stimulus for host immune systems.
Hwang, Jangsun,Son, Jaewoo,Seo, Youngmin,Jo, Yeonho,Lee, Kyungwoo,Lee, Dohyun,Khan, Muhammad Saad,Chavan, Sachin,Park, Chanhwi,Sharma, Anand,Gilad, Assaf A.,Choi, Jonghoon Elsevier 2018 Journal of industrial and engineering chemistry Vol.58 No.-
<P><B>Abstract</B></P> <P>Bacterial infections and resistance against antibiotics are on the rise despite new drug development. New developments in the field of nanomedicine are proving to be an alternative for traditional antibiotics. Silica nanoparticles (SiNPs) have a promising role in emerging nanomedicine because of their low cytotoxicity and efficient drug delivery potential. In current study, we developed and analyzed silica nanoparticles of ∼50nm in size that are capable of encapsulating small organic molecules and drugs, such as fluorescein isothiocyanate (FITC), doxorubicin (DOX), 4′, 6-diamidino-2-phenylindole (DAPI) and/or isoniazid (INH). Our drug delivery contains the anti-tuberculosis drug, INH, which is encapsulated in beta (β)-glucan-conjugated SiNPs. We focused on synthesizing and encapsulating SiNPs that have amine functional groups as well as the ability to conjugate with β-glucan molecules, making the nanocomplex both a drug carrier and a stimulus for host immune systems.</P> <P><B>Graphical abstract</B></P> <P>Beta-glucan modified silica nanoparticles carrying and secreting anti-tuberculosis drug molecules: SA treated Glu was presenting carboxyl groups on their surface while SiNPs encapsulating INH were terminated with amine groups. Glu and SiNPs were then conjugated with by EDC/NHS linkers. INH@SiNPs/Glu complexes released drug molecules while macrophages recognizing Glu secreted cytokines (Red arrows: Glu, Yellow arrows: INH encapsulated SiNPs: Right, Drug release profiling: Left).</P> <P>[DISPLAY OMISSION]</P>
Use of Nanoscale Materials for the Effective Prevention and Extermination of Bacterial Biofilms
이도현,서영민,Muhammad Saad Khan,황장선,조연호,손재우,이경우,박찬휘,Sachin Chavan,Assaf A. Gilad,최종훈 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.1
Biofilms have been shown to cause most human infections. The prevention and extermination of bacterial biofilms has always presented a major challenge in the clinic. The failure of traditional antibiotics and the development of bacterial resistance against these measures is on the rise. Nanoscale materials possess the advantage of presenting enhanced surface properties of bulk materials, and are emerging as effective agents for deterring microbial growth. This review article summarizes the fundamentals of bacterial growth, biofilm formation, mechanisms for antibacterial technologies, and usage of nanoparticles for the prevention and extermination of biofilms. Further research is required with respect to the appropriate usage of nanoparticles for the effective control of biofilms to save human lives and reduce healthcare costs.