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- 저자 : ( Ryoji Maekura ) (검색결과 1 건)
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( Yukihiro Yano ),( Hiroyuki Kagawa ),( Seigo Kitada ),( Masahide Mori ),( Soichiro Yokota ),( Ryoji Maekura ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To date, the clinical signifi cance of Mycobacterium (M.) gordonae isolated from respiratory specimens has not been well investigated. This study aimed to determine the clinical signifi cance of M. gordonae isolated from respiratory specimens and the validity of the diagnostic guideline for pulmonary nontuberculous mycobacterial (NTM) disease as applied patients with M. gordonae. Methods: A retrospective observational study was conducted on all patients from whom M. gordonae was isolated between 2003 and 2013 in our institution, which is a specialist hospital for respiratory disease in Osaka, Japan. M. gordonae was identifi ed by the DNA-DNA hybridization method. We identifi ed patients who met diagnostic criteria according to the guideline of the American Thoracic Society (ATS) for pulmonary NTM disease and confi rmed fi nal defi nitive diagnosis of such patients. Results: M. gordonae isolates were found in respiratory specimens from 152 patients who were examined multiple times. A total of 10 patients met the diagnostic criteria based on pulmonary symptoms, abnormal radiographic fi ndings, and multiple identifi cations of M. gordonae from respiratory specimens. Among these 10 patients, only 2 were confi rmed as having pulmonary disease caused by M. gordonae. Colonization or contamination was diagnosed in the remaining 150 patients. The ratio of patients confi rmed as having pulmonary disease caused by M. gordonae to those from whom M. gordonae was isolated, was 2/152 (1.32%). The positive predictive value of the ATS guideline for pulmonary NTM disease when applied to patients with M. gordonae was 20% (2/10 patients). Conclusions: Occurrence of pulmonary disease caused by M. gordonae was rare and the present ATS guideline for pulmonary NTM disease may be inappropriate when applied to patients with M. gordonae.
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