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( Wei Hong Wang ),( Tae Gu Lee ),( Ra Hul S. Patil ),( Bara Mun ),( In Ho Yang ),( Hi Young Kim ),( Dong Yup Hahn ),( Dong Hwan Won ),( Ji Hye Lee ),( Ye Hee Lee ),( Hyuk Jae Choi ),( Sang Jip Nam ),( 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Chemical investigation of a Korean marine sponge, Minanchora sp. led to the isplation of three new steriodes (1-3). Compounds 1 and 2, designated as monan chosterols A abd B, resoectubely, represent the first example of steriods possessing the bicyclo[4.3.1] A/Brubg ststem from a natural source, Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRna expression of 1L-6, TNF-a and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells, Compounds 2 and 3 exhibited significant inhibitpry effects on the mRNA expression of 1L-6 without notable cytotoxocotu tp tje cells in a dose-dependent manner.