Reliability of Jack-up against Punch-through using Failure State Intelligent Recognition Technique

Tao Lyu,Changhang Xu,Guoming Chen,Yipei Zhao,Qingyang Li,Tantan Zhao 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.3

The preload operation of jack-up in complex multi-layered foundation requires enhanced understanding of its behaviour in punchthrough accident and suitable safety analysis tools for the assessment of their reliability for a particular site. In this study, reliability analysis model of jack-up against punch-through is established considering structural uncertainty. In order to identify the failure state, an improved reliability solution method has been developed based on Sparse Auto-Encoder (SAE) deep learning network model. Sparse self-coding algorithm is used to the training of the deep network, and Softmax regression model is established to solve the identification and classification problem of the output layer. The first application of the technique was the study of HYSY 941 jack-up platform. More specifically, numerical calculations of structure ultimate bearing capacity have been undertaken, and the influence of model parameters on the prediction accuracy of the failure state is discussed. The results show that implicit performance function can be constructed accurately using SAE-MC method by reflecting the relationship between different critical safety state and structural vulnerability. Compared with traditional BP neural network, deep learning network has higher prediction accuracy to failure probability. The dynamic risk grade in the process of preload operation can be determined quantitatively using the reliability analysis method mentioned in this paper.

Comparative Genomic and Genetic Functional Analysis of Industrial L-Leucine- and L-Valine-Producing Corynebacterium glutamicum Strains

( Yuechao Ma ),( Qixin Chen ),( Yi Cui ),( Lihong Du ),( Tuo Shi ),( Qingyang Xu ),( Qian Ma ),( Xixian Xie ),( Ning Chen ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.11

Corynebacterium glutamicum is an excellent platform for the production of amino acids, and is widely used in the fermentation industry. Most industrial strains are traditionally obtained by repeated processes of random mutation and selection, but the genotype of these strains is often unclear owing to the absence of genomic information. As such, it is difficult to improve the growth and amino acid production of these strains via metabolic engineering. In this study, we generated a complete genome map of an industrial L-valine-producing strain, C. glutamicum XV. In order to establish the relationship between genotypes and physiological characteristics, a comparative genomic analysis was performed to explore the core genome, structural variations, and gene mutations referring to an industrial L-leucine-producing strain, C. glutamicum CP, and the widely used C. glutamicum ATCC 13032. The results indicate that a 36,349 bp repeat sequence in the CP genome contained an additional copy each of lrp and brnFE genes, which benefited the export of L-leucine. However, in XV, the kgd and panB genes were disrupted by nucleotide insertion, which increase the availability of precursors to synthesize L-valine. Moreover, the specific amino acid substitutions in key enzymes increased their activities. Additionally, a novel strategy is proposed to remodel central carbon metabolism and reduce pyruvate consumption without having a negative impact on cell growth by introducing the CP-derived mutant H+/citrate symporter. These results further our understanding regarding the metabolic networks in these strains and help to elucidate the influence of different genotypes on these processes.

KCNQ1 and type 2 diabetes: study in Hubei Han Chinese and meta‐analysis in East Asian populations

Mustafa Abdo Saif Dehwah,Shuang Zhang,Keyi Qu,Hantao Huang,Aimin Xu,Qingyang Huang 한국유전학회 2010 Genes & Genomics Vol.32 No.4

Recent genome‐wide association studies in East Asian poulations reported the association of KCNQ1 variants with type 2 diabetes. In the present study, we first investigated the association between rs2237892 in KCNQ1 and type 2 diabetes in a Hubei Han Chinese population (223 type 2 diabetes patients and 201 controls). The frequencies of CC genotype and C allele in type 2 diabetes patients were significantly higher than those of controls group (CC: 51.6% vs 39.3%, P=0.001; C:72.2% vs 61.2%, P=0.001). The odds ratio for the risk allele C was 1.65 (95%CI 1.23–2.2, P=0.001). Then, we systematically reviewed the association of SNPs (rs2237892, rs2237895,rs2237897, rs2074196) in KCNQ1 with type 2 diabetes risk in a meta‐analysis. Significant heterogeneity between studies was found for SNPs rs2237892 and rs2237897. Combined odds ratios of the rs2237892 C, rs2237895 C, rs2237897 C,rs2074196 G allele were 1.35 (95% CI 1.29–1.41, P<0.0001),1.27 (95%CI 1.23–1.32, P<0.0001), 1.32 (95%CI 1.21–1.43,P<0.0001), 1.30 (95%CI 1.25–1.35, P<0.0001) respectively. Our results and meta‐analysis demonstrated that KCNQ1 polymorphisms were reproducibly associated with the risk of type 2 diabetes in Han Chinese and East Asian populations.

Influence of raw material grain composition on the properties of fused silica ceramics

Qingtao Wang,Sen Li,Huaqin Yu,Fengzhi Li,Huijun Xu,Haibo Qiao,Juncheng Liu,Qingyang Du 한양대학교 세라믹연구소 2017 Journal of Ceramic Processing Research Vol.18 No.8

Fused silica ceramics were prepared by slip casting method with various particle sizes (d50 ≈ 2.31 μm, 19.79 μm, and 71.46 μm)from three types of fused silica powder. The influence of raw material grain composition on the viscosity of slurry, bulk density,porosity, water absorption, and flexural strength of the fused silica ceramics was investigated. The slurry viscosity wasmeasured by an XND-1 viscometer. The bulk density, porosity, and water absorption of the sintered samples were obtainedby the Archimedes method. The flexural strength was measured by a three-point bending test. The phase composition andmicrostructure of the samples were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Theresults show that when the grain composition was 5 : 3 : 2, slurry viscosity was 150.79 mPa·s with solid content of 75%, thefused silica ceramic particles were packed most tightly and demonstrate bulk density of 2.02 g/cm3, porosity of 6.99%, waterabsorption of 3.47%, and flexural strength of 51.27 MPa.

Electron transport properties of Y-type zigzag branched carbon nanotubes

MaoSheng Ye,HangKong, OuYang,YiNi Lin,Quan Ynag,QingYang Xu,Tao Chen,LiNing Sun,Li Ma Techno-Press 2023 Advances in nano research Vol.15 No.3

The electron transport properties of Y-type zigzag branched carbon nanotubes (CNTs) are of great significance for micro and nano carbon-based electronic devices and their interconnection. Based on the semi-empirical method combining tight-binding density functional theory and non-equilibrium Green's function, the electron transport properties between the branches of Y-type zigzag branched CNT are studied. The results show that the drain-source current of semiconducting Y-type zigzag branched CNT (8, 0)-(4, 0)-(4, 0) is cut-off and not affected by the gate voltage in a bias voltage range [-0.5 V, 0.5 V]. The current presents a nonlinear change in a bias voltage range [-1.5 V, -0.5 V] and [0.5 V, 1.5 V]. The tangent slope of the current-voltage curve can be changed by the gate voltage to realize the regulation of the current. The regulation effect under negative bias voltage is more significant. For the larger diameter semiconducting Y-type zigzag branched CNT (10, 0)-(5, 0)-(5, 0), only the value of drain-source current increases due to the larger diameter. For metallic Y-type zigzag branched CNT (12, 0)-(6, 0)-(6, 0), the drain-source current presents a linear change in a bias voltage range [-1.5 V, 1.5 V] and is symmetrical about (0, 0). The slope of current-voltage line can be changed by the gate voltage to realize the regulation of the current. For three kinds of Y-type zigzag branched CNT with different diameters and different conductivity, the current-voltage curve trend changes from decline to rise when the branch of drain-source is exchanged. The current regulation effect of semiconducting Y-type zigzag branched CNT under negative bias voltage is also more significant.