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Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis
Deng, Qi-Wen,He, Bang-Shun,Pan, Yu-Qin,Sun, Hui-Ling,Xu, Ye-Qiong,Gao, Tian-Yi,Li, Rui,Song, Guo-Qi,Wang, Shu-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.
Deng, Shengzhong,Youn, Chan-Hyun,Liu, Qi,Kim, Hoe-Young,Yu, Taoran,Kim, Young-Hun Korea Information Processing Society 2008 Journal of information processing systems Vol.4 No.3
This paper proposes a policy adjuster-driven Grid workflow management system for collaborative healthcare platform, which supports collaborative heart disease diagnosis applications. To select policies according to service level agreement of users and dynamic resource status, we devised a policy adjuster to handle workflow management polices and resource management policies using policy decision scheme. We implemented this new architecture with workflow management functions based on policy quorum based resource management system for providing poincare geometrycharacterized ECG analysis and virtual heart simulation service. To evaluate our proposed system, we executed a heart disease identification application in our system and compared the performance to that of the general workflow system and PQRM system under different types of SLA.
Low Frequency Current Ripple Mitigation of Two Stage Three-Phase PEMFC Generation Systems
Deng, Huiwen,Li, Qi,Liu, Zhixiang,Li, Lun,Chen, Weirong The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.6
This paper presents a two stage three-phase proton exchange membrane fuel cell (PEMFC) generation system. When the system is connected to a three-phase load, it is very sensitive to the characteristics and type of the load. Especially unbalanced three-phase loads, which result in a pulsating power that is twice the output frequency at the inverter output, and cause the dc-link to generate low frequency ripples. This penetrates to the fuel cell side through the front-end dc-dc converter, which makes the fuel cell work in an unsafe condition and degrades its lifespan. In this paper, the generation and propagation mechanism of low frequency ripple is analyzed and its impact on fuel cells is presented based on the PEMFC output characteristics model. Then a novel method to evaluate low frequency current ripple control capability is investigated. Moreover, a control scheme with bandpass filter inserted into the current feed-forward path, and ripple duty ratio compensation based on current mode control with notch filter is also proposed to achieve low frequency ripple suppression and dynamic characteristics improvement during load transients. Finally, different control methods are verified and compared by simulation and experimental results.
The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
Qi-rui Hu,Yao Pan,Han-cheng Wu,Zhen-zhen Dai,Qing-xin Huang,Ting Luo,Jing Li,Ze-yuan Deng,Fang Chen The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2
Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.
Primary Research on Theoretical Performance and Powder Supply Characteristics of Powder Rocket
Deng, Zhe,Hu, Chun-bo,Hu, Song-qi,Xu, Yi-hua The Society for Aerospace System Engineering 2015 International Journal of Aerospace System Engineer Vol.2 No.2
The powder propellant rocket which uses micron-sized particles as fuel is storable and costly. Functions like thrust control and multiple-ignition can be realized by changing powder mass flow rate. In this paper, we discuss the theoretical performance of bi-propellant and mono-propellant powder rocket. When used as the fluidization gas, helium can improve specific impulse dramatically. The stability of the powder feeding device is preliminarily quantified through metal/N2O powder rocket hot fire tests.
Ultrafast dynamics control on ablation of Cu using shaped femtosecond pulse trains
Deng Jiannan,Qi Hongxia,Liu Xinyi,Li Xiaoyi,Tong Qiunan,Lian Zhenzhong,Li Juan,Bo Jinqiu,Fei Dehou,Chen Zhou,Hu Zhan 한국물리학회 2021 Current Applied Physics Vol.26 No.-
The ablation processes of Cu film are investigated using temporal shaped femtosecond pulse trains. The depth is modulated by changing the number and interval of the sub-pulses. The underlying ultrafast dynamic processes are discussed based on plasma shielding and electron multiple heating mechanisms. When the sub-pulse interval is less than 0.4 ps electron multiple heating is the dominant mechanism, while the plasma shielding dominates the subsequent ablation processes when the sub-pulse interval is larger than 0.4 ps. The curve of depth obtained by three pulse trains shows more significant oscillation as the function of sub-pulse interval under the lowfluence. We propose that the oscillation of depth is due to the coherent phonon oscillation excited by the pulse train. The study provides a basis for giving insight into the ultrafast dynamics for improving micromachining and nano-fabrications using shaped femtosecond pulse trains.
Experimental investigation of the preferred Strouhal number used in self-resonating pulsed waterjet
Deng Li,Youping Chen,Yong Kang,Zu’an Wang,Xiaoliang Wang,Qi Fan,Miao Yuan 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.9
Self-resonating pulsed waterjet (SRPW) is superior to plain waterjet in many ways and is being employed in numerous applications. To further improve the performance of SRPW, the optimal value of the preferred Strouhal number (S d ), which is used to determine the chamber length of a self-resonating nozzle, was experimentally studied at inlet pressures of 10 MPa and 20 MPa. The axial pressure oscillation peak and amplitude were used to evaluate the performance of SRPW, in order to find the optimum S d value. Results show that S dvalue determines the self-resonance behavior of an organ-pipe nozzle and greatly affects the intensity of the axial pressure oscillation. Under the experimental conditions, the optimum S d values are 0.315 and 0.278 respectively, corresponding to inlet pressures of 10 MPa and 20 MPa. Compared with the default value of 0.3 obtained from air jet experiment, the optimum S d value at inlet pressure of 10 MPa is a little larger and oppositely a bit smaller at inlet pressure of 20 MPa. Thus, if the inlet pressure is not considered, S d value of 0.3 is reasonable for determining the chamber length of a self-resonating nozzle for generating effective SRPW.
Deng, Shuhao,Sun, Yao,Yang, Jian,Zhu, Qi,Su, Mei The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.6
The full-bridge inverter, widely used for single-phase photovoltaic grid-connected applications, presents a leakage current issue. Therefore, an AC bypass branch is introduced to overcome this challenge. Nevertheless, existing modulation strategies entail drawbacks that should be addressed. One is the zero-crossing distortion (ZCD) of the AC current caused by neglecting the AC filter inductor voltage. Another is that the system cannot deliver reactive power because the AC bypass branch switches at the power frequency. To address these problems, this work proposes an optimized hybrid modulation strategy. To reduce ZCD, the phase angle of the inverter output voltage reference is shifted, thereby compensating for the neglected leading angle. To generate the reactive power, the interval of the negative power output is calculated using the power factor. In addition, the freewheeling switch is kept on when power is flowing into the grid and commutates at a high frequency when power is fed back to the DC side. In this manner, the dead-time insertion in the high-frequency switching area is minimized. Finally, the performances of the proposed modulation strategy and traditional strategies are compared on a universal prototype inverter. Experimental results validate the theoretical analysis.