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( Jana Mattova ),( Pavla Pouckova ),( Petr Urbanek ),( Martin Hruby ),( Jan Kucka ),( Miroslav Vetrik ),( Michaela Skodova ),( Petr Stepanek ),( Milos Petrik ),( Zbynek Novy ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Wilson`s disease is a genetic disorder caused by a malfunction of ATPase 7B that leads to high accumulation of copper in the organism and consequent toxic effects. We propose a gentle therapy to eliminate the excessive copper content with oral administration of insoluble non-resorbable polymer sorbents containing selective chelating groups for copper ions (Cu²<sup>+</sup> ions). Methods: Polymeric beads with the chelating agents triethylenetetramine, N,N-di(2-pyridylmethyl)amine and 8-hydroxyquinoline were investigated. We performed a long term experiment with Wistar rats fed a diet containing the particular polymers. Further, we investigated non-resorbability of polymeric beads. We measured organ radioactivity after oral administration of 8-hydroxyquinoline on polymer radiolabelled with iodine-125. Non-resorbability was also tested with small animal PET/CT imaging (using copper-64) in NMR mice. Results: In a long-term experiment with Wistar rats fed a diet containing the polymers, we have found that there were no signs of polymer toxicity and the addition of polymers to the diet led to a significant reduction in the copper contents in the kidneys, brains, and livers of the rats. 8-hydroxyquinoline on polymer radiolabelled with iodine-125 was not absorbed from the digestive tract after oral administration. Non-resorbability was also confirmed with PET/CT imaging. Conclusions: We have shown that polymers containing specific ligands could potentially be novel therapeutics for Wilson`s disease. Polymeric beads significantly reduced copper content in selected organs and they are non-resorbable from digestive tract and fully eliminated in feces after oral administration.
David Skoda,Barbora Hanulikova,Ales Styskalik,Vit Vykoukal,Petr Machac,Pavel Urbanek,Eva Domincova Bergerova,Lucie Simonikova,Ivo Kuritka 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-
In this work, a novel synthesis of homogeneous molybdenum silicate spheres under non-aqueous conditionsis presented. A preparation method is based on the condensation of molybdenum metal–organicframework-based precursor solution prepared via a microwave-assisted approach from bis(acetylacetonato)dioxomolybdenum and biphenyl-4,40-dicarboxylic acid with 3-aminopropyltriethoxysilane undernon-aqueous conditions. The as-prepared product was calcined at 500 C to obtain amorphous and porousmolybdenum silicate microspheres with homogeneously distributed molybdenum species within silicatematrix. The microspheres exhibit an average size of about 480 nm. This material was further studiedas a heterogeneous catalyst for the epoxidation of olefins via the model catalytic epoxidation of cyclohexenewith cumylhydroperoxide. High catalytic activity at the moderate temperature (65 C) with the conversionof 86% after 2 h and the high selectivity to cyclohexene oxide has been achieved. In addition,molybdenum silicate microspheres exhibit catalytic activity and high selectivity in the oxidation of anilineto nitrosobenzene.