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- 저자 : ( Nazneen Shaik Survay ) (검색결과 4 건)
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Nazneen Shaik Survay(쉐익나즈닌),EunYoung Ko(고은영),Chandrama Prakash Upadhyay(우파드하야),Jang Mi(장미),Se Won Park(박세원),DongHa Lee(이동하),Yi-Sook Jung(정이숙),Do-Young Yoon(윤도영),SaeJin Hong(홍세진) 한국원예학회 2010 원예과학기술지 Vol.28 No.5
고혈당 쥐에(Sprague-Dawley rat) 각종 야채와 과일을 섭취(1g/㎏ body weight) 한 후 oral glucose tolerance test(OGTT)을 실시하였다. 0분, 5분, 15분, 30분, 60분, 90분, 120분 후에 blood glucose levels(ΔBGLs)을 측정하였다. Under glucose curve(ΔAUCs)은 OGGT의 120분 후 계산하였으며 과일과 야채의 Total phenolic content(TPC)과 anti-oxidant activity (AOA)는 Folin Ciocalteu and DPPH(2, 2-diphenyl-1-picrylhydrazyl)을 통하여 특정하였다. 실험의 마지막은 Pearson’s correlations을 사용하여 TPC, AOA and ΔAUC 간의 상관관계를 분석하였으며 모든 통계수치는 unpaired Student’s t-test를 실시하였다. 과일중에서는 탠저린, 자두, 배가 저혈당 효과를 보였으며 야채중에서는 푸른잎 머스타드와 양배투, 치커리, 브로콜리가 감소된 ΔBGLs와 유효한 ΔAUC수치를 보여서 저혈당 효과에 효과적이었다. 효과적인 ΔAUC의 범위는 5548.2 ± 462.1에서부터 3823.3 ± 282.0㎎ · min/dL이며, TPC와 AOA의 범위는 0.063 ± 0.00에서부터 0.913 ± 0.14㎎/g GAE, 01.05 ± 0.08에서부터 75.46 ± 0.06%이다. 전체적으로 과일의 50%와 양체의 60-65%가 높은 TPC와 효과적인 AOA의 수치를 나타내었다. 우리는 이번 연구를 통하여 저혈당 효과가 있어 제2형 당뇨를 예방할 수 있는 과일과 채소류를 선별할 수 있었다. An in vivo oral glucose tolerance test (OGTT) was performed on hyperglycemic male Sprague-Dawley rats to assess the effect of fruits and vegetables (1 g · ㎏?¹ body weight) on blood glucose levels (ΔBGLs) at different time intervals of 0, 5, 15, 30, 60, 90 and 120 min. The areas under glucose curve (ΔAUCs) were calculated at 120 min of OGTT by trapezoid method. Total phenolic content (TPC) and anti-oxidant activity (AOA) of fruits and vegetables were assayed in vitro by Folin Ciocalteu and DPPH (2, 2-diphenyl-1-picrylhydrazyl) methods, respectively. At the end of the experiment the correlations among the parameters TPC, AOA and ΔAUC was estimated by Pearson’s correlations. Among fruit crops, tangerine, plum, grape and pear and among vegetables, blue leaf mustard, cabbage, chicory, broccoli and others exhibited significant hypoglycemic effects by reducing ΔBGLs with significant ΔAUC. The effective ΔAUC ranged from 5548.2 ± 462.1 to 3823.3 ± 282.0 ㎎-min · dL?¹. The TPC and AOA ranged from 0.063 ± 0.00 to 0.913 ± 0.14 ㎎ · g?¹ GAE and 01.05 ± 0.08 to 75.46 ± 0.06%, respectively. Overall, six fruits and fifteen vegetables exhibited higher TPC and one fruit and four vegetables exhibited higher AOA. There was a better correlation among TPC, AOA and ΔAUC of fruits and TPC & AOA of vegetables. We report that hypoglycemically significant fruits and vegetables investigated in this study have pharmacological importance which reduced ΔBGLs through insulin like activity and AOA in prevention of type-2 diabetes.
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New Genera of Flavonols and Flavonol Derivatives As Therapeutic Molecules
Survay, Nazneen Shaik,Upadhyaya, Chandrama Prakash,Kumar, Brajesh,Young, Ko-Eun,Yoon, Do-Young,Park, Se-Won The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.1
Natural products from plants and microorganisms traditionally have provided the pharmaceutical industry with one of the most important sources of "lead" compounds in the search for new drugs and medicines. The diversity of polyphenol structure is enormous. They are classified into several classes, the most important polyphenol in our food being phenolic acids and flavonoids, which include flavonol as one of subgroups. Flavonols are a group of plant secondary metabolites containing hydroxyl in $3^{rd}$ position of chromone ring of a '6+3' flavonoid ring structure. Several health beneficial activities have been attributed to these naturally occurring plant flavonols, including antioxidative, anticarcinogenic, vasoprotective, anti-inflammatory, neurodegenerative, antidiabetic, antiplatelet activities, among which antioxidative properties remain the main topic investigated in recent years. The main aim of this review is to put forward the pharmacological importance of major flavonols and newly found flavonol derivatives from the last 10 years and their related bioactivity as lead compounds. The bioactivity of these flavonoids depends on structure-activity relationship (SARs), the flavonols being one of the structurally active compounds. Most studies have demonstrated their occurrence and their absorption in humans, but the question remains as to which form is actually absorbed: aglycone, glycosidic or both. The major flavonols such as quercetin, kaempferol, myricetin, rutin, isorhamnetin, and galangin were found to exhibit anticancer activity. These flavonols also have positive effects on major diseases such as cardiovascular disease, type-2 diabetes, and Alzheimer's disease. They are also found to have therapeutic value against osteoporosis, platelet aggregation, and antioxidant activity, the major action of prevention.
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Review : New Genera of Flavonols and Flavonol Derivatives As Therapeutic Molecules
( Se Won Park ),( Do Young Yoon ),( Nazneen Shaik Survay ),( Chandrama Prakash Upadhyaya ),( Brajesh Kumar ),( Ko Eun Young ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.1
Natural products from plants and microorganisms traditionally have provided the pharmaceutical industry with one of the most important sources of “lead” compounds in the search for new drugs and medicines. The diversity of polyphenol structure is enormous. They are classified into several classes, the most important polyphenol in our food being phenolic acids and flavonoids, which include flavonol as one of subgroups. Flavonols are a group of plant secondary metabolites containing hydroxyl in 3rd position of chromone ring of a ``6+3`` flavonoid ring structure. Several health beneficial activities have been attributed to these naturally occurring plant flavonols, including antioxidative, anticarcinogenic, vasoprotective, anti-inflammatory, neurodegenerative, antidiabetic, antiplatelet activities, among which antioxidative properties remain the main topic investigated in recent years. The main aim of this review is to put forward the pharmacological importance of major flavonols and newly found flavonol derivatives from the last 10 years and their related bioactivity as lead compounds. The bioactivity of these flavonoids depends on structure-activity relationship (SARs), the flavonols being one of the structurally active compounds. Most studies have demonstrated their occurrence and their absorption in humans, but the question remains as to which form is actually absorbed: aglycone, glycosidic or both. The major flavonols such as quercetin, kaempferol, myricetin, rutin, isorhamnetin, and galangin were found to exhibit anticancer activity. These flavonols also have positive effects on major diseases such as cardiovascular disease, type-2 diabetes, and Alzheimer`s disease. They are also found to have therapeutic value against osteoporosis, platelet aggregation, and antioxidant activity, the major action of prevention.
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