Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder

Narae Yoon,Youngmin Huh,Hyekyoung Lee,Johanna Inhyang Kim,Jung Lee,Chan-Mo Yang,Soomin Jang,Yebin D. Ahn,Mee Rim Oh,Dong Soo Lee,Hyejin Kang,Bung-Nyun Kim 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.12

Objective Underconnectivity in the resting brain is not consistent in autism spectrum disorder (ASD). However, it is known that the functional connectivity of the default mode network is mainly decreased in childhood ASD. This study investigated the brain network topology as the changes in the connection strength and network efficiency in childhood ASD, including the early developmental stages. Methods In this study, 31 ASD children aged 2–11 years were compared with 31 age and sex-matched children showing typical development. We explored the functional connectivity based on graph filtration by assessing the single linkage distance and global and nodal efficiencies using resting-state functional magnetic resonance imaging. The relationship between functional connectivity and clinical scores was also analyzed. Results Underconnectivities within the posterior default mode network subregions and between the inferior parietal lobule and inferior frontal/superior temporal regions were observed in the ASD group. These areas significantly correlated with the clinical phenotypes. The global, local, and nodal network efficiencies were lower in children with ASD than in those with typical development. In the preschool-age children (2–6 years) with ASD, the anterior-posterior connectivity of the default mode network and cerebellar connectivity were reduced. Conclusion The observed topological reorganization, underconnectivity, and disrupted efficiency in the default mode network subregions and social function-related regions could be significant biomarkers of childhood ASD.

간호조무사의 일과 삶의 균형이 이직의도에 미치는 영향: 직무만족과 조직몰입의 매개효과를 중심으로

윤나라 ( Yoon Nara ),김일옥 ( Kim Ilok ) 한국보건사회연구원 2021 保健社會硏究 Vol.41 No.4

본 연구는 현직 간호조무사들이 지각하는 일과 삶의 균형, 직무만족, 조직몰입 및 이직의도 관계를 파악하고, 일과 삶의 균형이 이직의도에 영향을 미치는 과정에서 직무 만족과 조직몰입의 매개효과를 확인하기 위해 시도되었다. 간호간병통합서비스(S시, N시, U시), 요양병원(S시, N시, U시, I시, T시), 의원(S시, N시, I시) 등 총 11개의 기관에 근무하는 간호조무사 201명으로부터 자료를 수집하였고, 수집된 자료는 SPSS WIN 25.0을 이용하여 분석하였다. 본 연구의 분석 결과는 다음과 같다. 첫째, 일과 삶의 균형은 직무만족과 조직몰입과 유의한 양의 상관관계를 보이고, 이직의도에 음의 상관 관계가 있는 것으로 나타났다. 둘째, 일과 삶의 균형은 직무만족, 조직몰입 및 이직의도에 유의한 영향을 주는 것으로 나타났다. 셋째, 직무만족과 조직몰입은 일과 삶의 균형과 이직의도에 부분 매개효과를 보이는 것으로 나타났다. 연구 결과, 간호조무사의 이직 의도를 낮추기 위해서는 일과 삶의 균형을 향상하는 전략 개발이 요구되며, 특히 이를 확립하는 데 직무만족과 조직몰입을 높일 수 있는 전략이 필요함을 제시하였다. This study was attempted to identify the work-life balance, job satisfaction, organizational commitment and turnover intention that nursing assistants perceive and to identify the mediating effects of job satisfaction and organizational commitment in the process of work-life balance affecting turnover intention. Data were collected from 201 nursing assistants working at 11 institutions in integrated nursing services (S, N, U, U, I, T), and clinics (S, N, I, I). and The collected data were analyzed using SPSS WIN 25.0. The analysis results are as follows. First, work-life balance shows a significant positive correlation between job satisfaction and organizational commitment, and there is a negative correlation in turnover intention. Second, work-life balance has been shown to have a significant effect on job satisfaction, organizational commitment and turnover intention. Third, job satisfaction and organizational commitment showed partial mediating effects on work-life balance and turnover intention. The results of this study suggest that in order to reduce the turnover of nursing assistants, it is necessary to develop strategies that can improve job satisfaction and organizational commitment, especially in establishing strategies that can improve work-life balance.

왕겨에서 Tricin과 Tricin 4"-O-(threo-β-guaiacylglyceryl) Ether(TTGE) 추출 조건의 최적화

윤나라(Nara Yoon),이상훈(Sang Hoon Lee),장귀영(Gwi Yeong Jang),이윤정(Yoon Jeong Lee),Li Meishan,김민영(Min Young Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.12

본 연구에서는 왕겨 중의 tricin과 TTGE의 함량을 확인하고, 추출용매의 에탄올 농도(50, 60, 70, 80 및 90%), 추출방법(교반 및 초음파 추출) 및 추출시간(0.5~48시간)이 tricin과 TTGE의 추출에 미치는 영향을 살펴보았다. 왕겨의 tricin과 TTGE의 함량은 각각 82.20 μg/g 및 53.12 μg/g이었다. Tricin 및 TTGE의 최적 추출용매의 에탄올 농도 50, 60, 70, 80 및 90%에 따라 tricin은 각각 66.03, 70.70, 76.11, 66.16 및 23.99%를, TTGE는 각각 64.56, 68.14, 71.42, 60.29 및 16.84%의 회수율을 보여 70% 농도가 가장 높았다. 초음파 추출 시 tricin 회수율은 2시간 처리에서 83.30% 그리고 TTGE는 1시간 처리 시 71.80%로 높았다. 교반 추출 시 추출시간의 증가에 따라 회수율은 증가하였으며, tricin은 48시간 추출 시 92.34% 그리고 TTGE는 24시간 추출 시 76.89%로 높았다. 이상의 결과로부터 tricin과 TTGE를 가장 효율적으로 추출할 수 있는 조건은 추출용매의 에탄올 농도 70%로 1시간 초음파 추출이라 판단된다. This study was conducted to evaluate the effects of extraction conditions on tricin and tricin 4"-O-(threo-β -guaiacylglyceryl) ether (TTGE) extracted from rice hull (Oryza sativa L.). Extraction conditions were an ethanol concentration of extraction solvent of 50~90%, extraction time of 0.5~48 h, and ultrasonic-assisted and agitated extraction as extraction methods. The total tricin and TTGE contents of rice hull were 82.20 μg/g and 53.12 μg/g, respectively. Recovery of tricin and TTGE increased to 76.11% and 71.42% with increasing ethanol concentration until 70% and then decreased above 80%, respectively. In ultrasonic-assisted extraction, highest recovery of tricin was 83.30% after 2 h of extraction and TTGE was 71.80% after 1 h of extraction. In agitated extraction, highest recovery of tricin was 92.34% after 48 h and TTGE was 76.89% after 24 h of extraction. Therefore, optimum extraction conditions for tricin and TTGE of rice hull were 70% ethanol concentration and ultrasonic-assisted extraction for 1 h.

발아 벼로부터 tricin 4-O-(threo-β-guaiacylglyceryl) ether 생성균주의 분리 및 동정

윤나라(Nara Yoon),장귀영(Gwi Yeong Jang),이윤정(Yoon Jeong Lee),Meishan Li,김민영(Min Young Kim),김현영(Hyun Young Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품과학회 2016 한국식품과학회지 Vol.48 No.4

본 연구는 왕겨에서 tricin 4-O-(threo-β-guaiacylglyceryl) ether (TTGE)를 생성시키는 균주를 분리와 동정하기 위하여 실시하였다. 발아 벼 추출물을 MYP, PDA, YM 및 LB 배지에 배양하고 각 배지에서 분리한 균을 왕겨에 접종해 TTGE 생성량을 측정한 결과 PDA 배지에서 자란 균에 의한 TTGE의 생성량(339.30 μg/g)이 가장 많았다. 분리한 균을 동정한 결과 Burkholderia vietnamiensis로 확인하였으며, 형태학적 및 생물학적 특성을 살펴본 결과 catalase 활성을 갖는 short rod 형태의 Gram 세균인 것으로 확인해 기존 Burkholderia 속의 특성과 일치하였다. 또한 분리한 세균을 살균한 왕겨에 접종하여 배양시킨 결과 배양기간에 따라 TTGE의 함량은 증가하였으며, 72시간 동안 배양에서 435.86 μg/g로 가장 많은 증가를 나타내었다. 이러한 결과는 폐기되는 왕겨를 활용함으로써 왕겨의 함유된 TTGE의 함량을 증대시켜 기능소재로 사용할 수 있는 기초 자료가 될 것으로 판단된다. This study was conducted to isolate and identify a microorganism that increases tricin-O-(threo-β-guaiacylglyceryl) ether (TTGE) content in the hulls of rice (Oryza sativa L.). Bacteria from germinated rice were isolated by enrichment cultivation using yeast mold, luria bertani, potato dextrose and mannitol egg york polymyxin broths. The highest increase in TTGE content (339.30 μg/g) was achieved by a microorganism isolated by PDA enrichment cultivation. On the basis of 16S RNA sequence homology and phylogenetic analysis, the isolated bacterium was identified to have 100% similarity with Burkholderia vietnamiensis. The isolated bacteria were short rods, negative for the Gram stain, and positive for the catalase test. The highest TTGE level was 435.86 μg/g in 72-h fermented samples, representing a 2.5x increase compared with the control (175.65 μg/g). In conclusion, the bacterium isolated from germinated rice extract was Burkholderia vietnamiensis, and the optimum fermentation period to maximize TTGE levels was 72 h. These findings might help in developing functional materials using rice hulls, a waste product of rice milling.

열처리와 발아에 따른 왕겨(Oryza sativa L.)의 Tricin과 Tricin 4′-O-(Threo-β-Guaiacylglyceryl) Ether 함량

윤나라(Nara Yoon),장귀영(Gwi Yeong Jang),이윤정(Yoon Jeong Lee),Meishan Li,김민영(Min Young Kim),김현영(Hyun Young Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.5

본 연구에서는 열처리 및 발아와 발아 벼로부터 추출한 조효소액에 의한 왕겨의 tricin과 4’-O-(threo-β-guaiacylglyceryl) ether(TTGE)의 함량 변화에 대해 살펴보았다. 열처리에 의한 왕겨의 tricin과 TTGE의 함량은 온도 및 시간이 증가함에 따라 증가하였고 130℃에서 1시간 처리하였을 때 각각 253.12 및 208.39 ㎍/g으로 가장 높게 나타났으며, 발아 2일차에서 각각 118.20 및 95.37 μg/g으로 가장 높게 나타났다. 발아일수별 벼의 조효소액을 여과한 조효소액 및 여과 후 남은 잔여물을 접종한 결과 여과한 조효소액의 처리구에서는 뚜렷한 함량 차이가 없었으나 잔여물을 처리하였을 때 tricin 및 TTGE의 함량이 유의적으로 증가하였다. 특히 발아 벼 6일 차에서 각각 361.76 및 308.08 ㎍/g으로 가장 많은 함량을 나타내었다. 이상의 결과로부터 tricin과 TTGE의 함량을 가장 많이 증대시킬 수 있는 조건은 발아 6일차 벼로부터 추출한 조효소액 여과 잔여물을 처리한 경우로 나타났다. This study was conducted to evaluate the effects of heat treatment and germination on tricin and tricin 4’-O-(threo-β-guaiacylglyceryl) ether (TTGE) formation from rice hull (Oryza sativa L.). Heat treatments were conducted at 80∼140℃ for 1∼5 h. Germination periods were 1∼6 days at 37℃. Germinated rough rice extracts were classified as non-filtrated, filtrated, and residue after filtration. For heat treatment, the highest contents of tricin and TTGE were 253.12 and 208.39 ㎍/g at 130℃ after 1 h, respectively. For germination, the highest contents of tricin and TTGE in rice hull were 118.20 and 95.37 ㎍/g after 2 days, respectively. In the germinated rough rice extract treatment, the highest contents of tricin and TTGE were 361.76 and 308.08 ㎍/g, respectively, in residue after filtration of germinated rice extract for 6 days. Therefore, the optimum conditions for tricin and TTGE formation were heat treatment at 130℃ for 1 h, germination for 2 days, and addition of residue after filtration of germinated rough rice extract for 6 days.

인공신경망을 이용한 평면프레임구조물의 시스템식별

尹鍾列,林나라 弘益大學校 科學技術硏究所 2002 科學技術硏究論文集 Vol.13 No.-

A method for identifying system parameters of a damaged plane frame structure using an artificial neural network is developed. When a frame is damaged, the modal shapes change and they contain the information on damage locations and extents. Throughout the changes of the structural responses, the neural network identifies system parameters and assesses damage locations and extents. The neural network is trained with modal shape and damage obtained from a dynamic model. Backpropagation neural network is used to solve the inverse problem. The method for selecting the effective mode in training the neural network is suggested. Two-bay, two-story frame structure is used in the numerical tests. Through the suggested method, system parameters and damage of a frame structure are identified and assessed.

Development of Procedures for Compression and Packaging of Spent Filter

Narae Lee,Moonoh Kim,Ji Soo Yoon,Ji Hoon Lee 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2

In this study, the process of compressing/packaging the spent filters of Kori Unit 1, which was conceptually presented in the previous study, is advanced so that disposal suitability for each step can be secure efficiently. In particular, the differences between the previous study and this study are that the disposable filters are screened using an In-Situ Object Counting System (ISOCS), and the method of collecting representative samples for development of scaling factor is specified. The process of compressing/packaging the spent filters consists of 7 stages as follows. 1) Collecting: The spent filters temporarily stored in the filter room are collected by dose and type remotely using a robot system to minimize the radiation exposure of workers according to a pre-established packaging plan. 2) Screening: The gamma activity concentration of the spent filters received by the robot system is measured by ISOCS. The spent filters below the low-level waste concentration limit and the surface dose are transferred into the compression system, while the others are returned in the filter room again. 3) Sampling: The external perforator drilling/cutting the filter was developed for sampling required for the new scaling factors. Since the sampling is collected remotely, the risk of exposure to workers can be reduced. The newly developed scaling factor will be used to verify the disposal suitability of the packages. 4) Compression: According to the pre-established plan, the spent filter collected by dose and type, is supplied to the compression system considering the dose and radionuclide inventory. Whether to additionally store the compressed filter in the drum is determined by checking the accumulated dose. 5) Immobilization: Immobilization with a safety material is necessary when inhomogeneous wastes, like spent filters, have the total radionuclide concentration with a half-life of more than 20 years is 74,000 Bq/g or more and for filling rate or non-dispersible treatment of particulates. 6) Packaging and Analysis: Waste information is labelled onto the package after the measurements of surface dose rate and surface contamination. Finally, using the drum assay system, the gamma radionuclide concentration is measured to identify at least 95% of the total radioactivity concentration of the package. 7) Temporary Storage and Delivery: The packages are moved to temporary storage in the plant prior to disposal. After establishing the plan for delivery and applying for a takeover request to KORAD, if the acceptance inspection is passed, the packages are transported to the disposal facility.

Cost Benefit Analysis of Treatment Process for Spent Filter

Narae Lee,Jisoo Yoon,Kyung Rok Park,Moonoh Kim 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

The treatment process for Spent Filter(SF) of Kori-1 was developed that includes the following : 1) Taking out by robot system 2) Screening by ISOCS 3) Collection of representative samples using a sampling machine 4) Compression 5) Immobilization 6) Packaging and nuclide analysis and 7) Delivery/disposal. Although the robot system, ISOCS, sampling machine and immobilization facility are essentially required for building the above processing but decision to build the compression system and nuclide analysis system must be made after reviewing the need and cost benefit for their construction. In addition, for effcient SF treatment, it is necessary to determine the nuclide concentration range of the SF to which immobilization will be applied. In this study, a cost benefit analysis was performed on existing and alternative methods for processes related to compression treatment, nuclide analysis and immobilization methods, which are greatly affected by economics and efficiency according to the design. First, although the disposal cost is reduced with reducing the number of packaging drums by compressed and packaged but the expected benefits not be equal to or greater than the cost invested in building a compression system. As a result, non-compressed treatment of SF is expected to be economical because the construction cost of compression system is more expensive than the benefits of reducing disposal costs by compression. Second, a cost benefit analysis of direct and indirect nuclide analysis methods was performed. For indirect analysis, scaling factors should be developed and the drum scanner suitable for the analysis for DAW should be improved. As a result, direct analysis applied grouping options is expected to be more economical than indirect analysis requiring the cost for developing scaling factors and improving the scanner. Third, it is timeconsuming and inefficient to distinguish and collect filters that are subject to be immobilized according to the waste acceptance criteria among the disorderly stored SFs in the filter rooms. If the benefits of immobilization of the SFs selectively are not greater than the benefits of immobilization of all SFs, it can be economical to immobilize all SFs regardless of the nuclide concentration of them. As a result, it is more economical to immobilize all SFs with various nuclide concentrations than to selectively immobilize them. The conclusion of this study is that it is not only cost-effective but also disposal-effective to design the treatment process of SF to adopt non-compressed processing, direct analysis and immobilization of all SFs.

New K-GMT Science Program

Narae Hwang,Jae-Joon Lee,Joon Hyeop Lee,Byeong-Gon Park,Yoon-Kyung Seo 한국천문학회 2013 天文學會報 Vol.38 No.1

Evaluation of Radioactive Waste Characteristics in PC-HIC

NaRae Lee,JiHoon Lee,MiHyun Lee,YoungHwan Hwang,Jisoo Yoon 한국방사성폐기물학회 2021 한국방사성폐기물학회 학술논문요약집 Vol.2021 No.06