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RISS 인기검색어
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- 저자 : ( Nana Keum ) (검색결과 3 건)
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( Nana Keum ),( Dong Hoon Lee ),( Woong Ju ),( Yun Hwan Kim ),( Seung Cheol Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Previous highest versus lowest meta-analyses suggested that recreational physical activity is associated with a reduced risk of endometrial cancer. However, they are limited to the qualitative assessment of the relationship. By conducting dose-response meta-analysis, we aim to quantify the amount of recreational physical activity associated with a reduced risk of endometrial cancer and identify the shape of dose-response relationship. PubMed and Embase were searched up to August 2013 for observational studies investigating the association between recreational physical activity and endometrial cancer risk. Summary relative risks (RRs) associated with a 4 MET-hour/week were estimated, using random- effects dose-response meta-analysis. Four case-control studies and three cohort studies were included in these analyses. The SRR for a 4 MET-hour/week of recreational physical activity was 0.93 (95% CI: 0.89-0.96) for case-control studies, and 0.99 (95% CI: 0.97-1.00) for cohort studies. There was no evidence for a threshold effect of recreational physical activity on the risk of endometrial cancer risk. These findings provide quantitative evidence suggesting additional reduction in endometrial cancer risk may occur with more recreational physical activity.
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( Woong Ju ),( Nana Keum ),( Dong Hoon Lee ),( Yun Hwan Kim ),( Eun Young Cho ),( Seung Cheol Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The aim of this study was to evaluate whether dietary intake of red meat is related to the risk of endometrial cancer (EC). We searched PubMed, EMBASE, and the Cochrane Library in April 2013 and additionally in June 2013, using common keywords related to red meat and ECs. Two of the authors independently selected all studies retrieved from the databases and bibliographies based on the pre-determined selection criteria. We performed conventional meta-analyses with selected observational studies and a dose-response meta-analysis only with case-control studies. Out of 342 articles retrieved from databases and relevant bibliographies, a total of 16 studies were included in the final analyses. A total of 5,419 cases and 12,654 controls were analyzed in the meta-analysis of 11 case-control studies, and 2,549 cases among 247,746 participants were analyzed in the meta-analysis of five prospective studies. In a random-effect conventional meta-analysis of 11 case-control studies, red meat consumption was associated with increased risk of EC (summary relative risk [SRR],1.43; 95% confidence interval [CI], 1.15-1.79). In dose-response meta-analysis of case-control studies, red meat intake increased the risk of EC with SRR of 1.06 (95% CI, 1.05-1.07) per 10 g/day increment. In a random-effect meta-analysis of five prospective cohort studies, there is no significantly increased risk of EC for red meat intake (SRR, 0.97; 95% CI, 0.85-1.11). Our meta-analysis found that an association between red meat consumption and the risk of EC with dose-response relationship with case-control studies, whereas there was no evidence to support the association in analysis of prospective studies.
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Effect of Food Sensitivity on Overweight was Assessed Using Food-specific Serum IgG Levels
Minhyeong LEE,Soyoun KIM,Hyeonmin GIL,Eugene CHEON,Nana KEUM,Youngeun KWON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Obesity has become a global epidemic, and overweight is a gateway to obesity. While it has been previously suggested that the food sensitivity is associated with obesity by causing chronic inflammation, the detailed effects and the mechanisms are not clearly elucidated. Understanding the association between food sensitivity and overweight is important for public health, and we studied this association by comparing the levels of total IgGs as well as food-specific IgGs (food-sIgG) between overweight and lean groups. We collected serum samples from 164 healthy participants along with their dietary information and body mass index (BMI). The amount of IgG was determined by microarray-based assays and the statistical analysis was carried out by converting the measure concentration to decile scores via the Wilcoxon rank-sum test. The total IgG and total food-sIgG scores were comparable between the groups (P >0.05), precluding chronic inflammation as the main cause of overweight. On the other hand, food-sIgG scores against dairy products and seafood were significantly higher (P <0.05) in the overweight group. The dietary information indicates the food-sIgG scores were not associated with the actual consumption (P >0.05), suggesting the higher food-sIgG as an indicator of food sensitivity rather than the result of higher consumption. This result suggests that the food-elimination therapy based on food sensitivity analysis could be effective treatment for overweight individuals.
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