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Suguru Odajima,Toshiyuki Seki,Sayako Kato,Keisuke Tomita,Yuichi Shoburu,Eitaro Suzuki,Masataka Takenaka,Motoaki Saito,Hirokuni Takano,Kyosuke Yamada,Aikou Okamoto 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Objective: Direct oral anticoagulants (DOACs) are increasingly being used for the treatment of cancer-associated venous thromboembolism (CAT). However, there is limited evidence of the efficacy of DOACs for the treatment of gynecological CAT. Thus, this study aimed to investigate the efficacy and safety of edoxaban for the treatment of gynecological CAT using Japanese real-world data. Methods: We reviewed the medical records of patients with 371 gynecological cancer who received edoxaban or vitamin K antagonist (VKA) between January 2011 and December 2018. Results: Altogether, 211 and 160 patients were treated with edoxaban and VKA, respectively. Fourteen patients (6.8%) in the edoxaban group and 22 (13.8%) in the VKA group showed recurrence of venous thromboembolism (VTE). Cumulative VTE recurrence was not significantly different between the 2 groups (p=0.340). Adverse events occurred in 15 (7.1%) and 11 (6.9%) patients in the edoxaban and VKA groups, respectively (p=0.697). Subgroup analysis of the edoxaban and VKA groups according to different tumor types, including ovarian, endometrial, and cervical cancer, showed equivalent outcomes in terms of VTE recurrence and adverse events. Patients without pulmonary embolism (PE) were mostly omitted from initial unfractionated heparin (UFH) therapy prior to administration of edoxaban. However, this did not increase the recurrence of VTE. Conclusion: This study confirmed that edoxaban is effective and safe for the treatment of gynecological CAT. This finding was consistent for different types of gynecological cancer. Additionally, initial UFH therapy prior to the administration of edoxaban may be unnecessary for patients without PE.
DRL1 Regulates Adaxial Leaf Patterning and Shoot Apical Meristem Activity in Arabidopsis
( Kiu Hyung Cho ),( Hoon Sung Choi ),( Motoaki Seki ),( Sang Eun Jun ),( Young Byung Yi ),( Kazuo Shinozaki ),( Hirokazu Tsukaya ),( Gyung Tae Kim ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.4
Leaf shape is controlled early on by initiation at the shoot apical meristem (SAM), as well as by changes in the rates and planes of cell division and the polarity-dependent differentiation of leaf cells. To elucidate the regulation of this differentiation by signal(s) from the SAM, we screened for mutations in genes that might be involved in these early processes. A novel recessive mutant, 356-2 [identified as a new allele of the deformed root and leaf1 (drl1) mutant], was isolated from a collection of Ds transposon insertion lines. The 356-2/drl1-101 mutant produces narrow, filamentous leaves and defective meristems. Its palisade cells have a spongy cell-like structure and are fewer in number, indicating that the leaves are abaxialized. Interestingly, some of those filament-like leaves have no vascular tissues inside their blades. DRL1 encodes a protein similar to the yeast elongator-associated protein (EAP) KTI12. The amino acid sequence of DRL1 is universally conserved in prokaryotes and eukaryotes. These facts suggest that DRL1 might positively regulate leaf polarity and SAM activity by controlling cell proliferation and differentiation.
Jung, Jae-Hoon,Park, Ju-Hyung,Lee, Sangmin,To, Taiko Kim,Kim, Jong-Myong,Seki, Motoaki,Park, Chung-Mo American Society of Plant Biologists 2013 The Plant cell Vol.25 No.11
<P>Short-term cold stress delays flowering by activating the floral repressor <I>FLOWERING LOCUS C</I> (<I>FLC</I>). This study shows that the cold signaling attenuator HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (HOS1) acts as a chromatin remodeling factor for <I>FLC</I> regulation under short-term cold stress by antagonizing the actions of FVE and its interacting partner histone deacetylase 6.</P>