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Moon Haeng Hur,Yuri Cho,Do Young Kim,Jae Seung Lee,Gyoung Min Kim,Hyo-Cheol Kim,Dong Hyun Sinn,Dongho Hyun,Han Ah Lee,Yeon Seok Seo,In Joon Lee,Joong-Won Park,Yoon Jun Kim 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Background/Aims: Transarterial radioembolization (TARE) has shown promising results in treating advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). However, whether TARE can provide superior or comparable outcomes to tyrosine kinase inhibitor (TKI) in patients with HCC and PVTT remains unclear. We compared the outcomes of TARE and TKI therapy in treatment-naïve patients with locally advanced HCC and segmental or lobar PVTT. Methods: This multicenter study included 216 patients initially treated with TARE (n=124) or TKI (sorafenib or lenvatinib; n=92) between 2011 and 2021. Baseline characteristics were balanced using propensity score matching (PSM) or inverse probability of treatment weighting (IPTW). The primary outcome was overall survival (OS). The secondary outcomes included progression-free survival (PFS) and objective response rate (ORR). Results: In the unmatched cohort, the median OS of the TARE and TKI groups were 28.2 and 7.2 months, respectively (P<0.001), and the TARE group experienced significantly and independently longer OS compared to the TKI group (adjusted hazard ratio=0.41, 95% confidence interval=0.28–0.60, P<0.001). Similar results were observed in the study cohorts balanced with IPTW (P=0.003) or PSM (P=0.004). Although PFS was comparable between the two groups, the TARE group showed a trend of prolonged PFS in a subpopulation of patients with Vp1 or Vp2 PVTT (P=0.052). In the matched cohorts, the ORR of the TARE group was 53.0–56.7%, whereas that of the TKI group was 12.3–15.0%. Conclusions: For patients with advanced HCC with segmental or lobar PVTT and well-preserved liver function, TARE may provide superior OS compared to sorafenib or lenvatinib.
허문행(Hur, Moon-Haeng) 한국산학기술학회 2010 한국산학기술학회 학술대회 Vol.- No.-
최근 네트워크의 발달로 인해 네트워크 감사데이터의 양이 점점 증가하고 있다. 이렇게 증가하는 네트워크 감사데이터를 능동적이고 효율적으로 분석하기 위한 연구가 진행되고 있다. 하지만 지금까지의 연구들은 특정 침입탐지시스템에 제한되어 데이터 마이닝 기법을 적용하여 감사데이터를 분석하고 침입탐지모델을 구축하는 연구였다. 따라서 이 논문에서는 특정 침입탐지시스템에 의존하지 않고 감사데이터를 효율적으로 분석하여 알려지지 않은 공격패턴이나 규칙들을 발견하여 보안정책 실행시스템에서 활용할 수 있도록 하기위한 감사데이터 분석 마이너를 설계하고 구현하였다. 보안관리자는 구현된 감사데이터 마이너를 이용하여 원하는 정보를 가공 추출하여 고수준의 의미추출에 이용할 수 있다.
데이터마이닝을 이용한 침입 탐지 시스템의 경보데이터 축약기법
허문행(Hur, Moon-Haeng) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-
이 논문에서는 데이터마이닝의 클러스터링을 이용한 경보 데이터 축약기법을 제안한다. 제안된 클러스터링 기반 경보데이터 축약기법은 데이터간의 유사성을 이용한 경보 데이터의 그룹화를 통해 생성된 모델을 이용하여 새로운 경보 데이터에 대한 분류를 자동화할 수 있다. 이것은 과거에 탐지된 공격의 형태뿐만 아니라 새로운 혹은 변형된 경보의 분류나 분석에도 이용할 수 있다. 또한 생성된 클러스터의 생성 원인의 분석을 이용한 클러스터 간의 시퀀스의 추출을 통해 사용자가 공격의 순차적인 구조나 그 이면에 감추어진 전략을 이해하는데 도움을 주며, 현재의 경보 이후에 발생 가능한 경보들을예측할 수 있다.
SUBACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN RATS
Moon, Chang-Kiu,Park, Kwang-Sik,Mock, Myung-Soo,Jung, Myung-Kiu,Kim, Ji-Young,Lee, Yong-Soon,Jeong, Ja-Young,Hur, Gyeung-Haeng,Kang, Kyung-Sun,Hwang, Gui-Seo,Kim, Seong-Gon,Won, Hyun-Soon 한국독성학회 1989 Toxicological Research Vol.5 No.2
Subacute toxicity of Hantabax, epidemic hemorrhagic fever vaccine, was investigated in Sprague-Dawley rats with subcutaneous injection. Any significant toxic clinical symptom was not observed in the treated rats during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in organs examined.
Park, Moon-Sic,Shim, Hee-Sang,Baek, Seung Heon,Kim, Jung Gu,Hur, Do Haeng Elsevier 2017 Annals of nuclear energy Vol.103 No.-
<P><B>Abstract</B></P> <P>The purpose of this work is to understand the pre-oxidation effect of fuel cladding surface on crud deposition in simulated primary water of PWRs at 328°C. Crud deposition tests were performed using ZIRLO™ (ZIRLO™ is a trademark of Westinghouse Electric Company LLC in the United States of America) claddings with three different oxidation states under sub-cooled nucleate boiling conditions. Boiling characteristics on the cladding surfaces were also simultaneously monitored using acoustic emission technique. The deposited amount on the pre-oxidized claddings was increased by up to 45%, compared with that on the as-received clean cladding. The number of boiling events also showed higher values on the pre-oxidized claddings. The effect of the pre-oxidized layers is discussed in the view point of the degree of sub-cooled nucleate boiling, zeta potential and wettability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effect of the pre-oxidized layer of fuel claddings on crud deposition is presented. </LI> <LI> Water boiling on the cladding surfaces is monitored using acoustic emission method. </LI> <LI> The amount of crud deposits increases as the zirconium oxide layer is grown thicker. </LI> <LI> The hit number of the boiling signals shows higher values on the oxidized claddings. </LI> <LI> Based on the zeta potentials, adhesion of magnetite particles on the oxidized surfaces is favored. </LI> </UL> </P>
Shim, Hee-Sang,Park, Moon-Sic,Baek, Seung Heon,Hur, Do Haeng Elsevier 2018 Annals of nuclear energy Vol.121 No.-
<P><B>Abstract</B></P> <P>Deposits on fuel assemblies (crud) have been the main cause of local power shift, increased fuel cladding temperature, accelerated fuel cladding corrosion, and radiation buildup in nuclear power plants. We report the experimental results on aluminum oxide (Al<SUB>2</SUB>O<SUB>3</SUB>) as a fuel cladding coating for crud mitigation. Crud deposition tests were performed under a sub-cooled nucleate flow boiling condition in simulated primary water of pressurized water reactors at 328 °C. The amount of deposits on the Al<SUB>2</SUB>O<SUB>3</SUB>-coated cladding tube decreased by 23% compared with that on the uncoated cladding tube. The difference of zeta potentials between magnetite particle and cladding surface increased from 7.5 mV to 16.1 mV, when the cladding surface was coated with Al<SUB>2</SUB>O<SUB>3</SUB>. Therefore, the reduction of crud deposition can be attributed to the increased repulsive force between the magnetite particle and Al<SUB>2</SUB>O<SUB>3</SUB>-coated cladding surface. The effect of the Al<SUB>2</SUB>O<SUB>3</SUB> layer is discussed from the view point of zeta potential, wettability, and thermodynamic stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effect of aluminum oxide coated on fuel cladding on crud deposition was investigated. </LI> <LI> Crud deposition tests were performed in simulated PWR primary water at 328 °C. </LI> <LI> The crud mass decreased by 23% by the Al<SUB>2</SUB>O<SUB>3</SUB>-coating. </LI> <LI> Repulsive force between magnetite particle and cladding increased by the Al<SUB>2</SUB>O<SUB>3</SUB>-coating. </LI> </UL> </P>
고속 SSD와 대용량 HDD를 위한 하이브리드 저장 시스템에 대한 연구
변시우(Byun, Si-Woo),허문행(Hur, Moon-Haeng) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-
최근 산업체나 연구소에서 사용되는 중대형 데이터 서버에서 발생하는 가장 큰 오버헤드(bottleneck)중의 하나가 바로 저장 시스템이라 할 수 있다. 대표적인 저장 시스템으로서 전통적인 하드디스크 드라이브(HDD)와 더불어 최근 상용화된 Solid State Drive(SSD)가 주목 받기 시작하였다. 본 연구의 목표는이러한 대용량 HDD 및 고속 SSD에 대하여, 저장 장치로서의 약점을 상호 보완하면서, 장점을 강화하여, 최종적으로 입출력 성능을 극대화할 수 있는 새로운 융합형 데이터 저장 시스템(Hybrid-RAID) 개발이다. Hybrid 저장 시스템 개발을 위한 최근의 기술 연구 및 기반 기술의 설계 및 구현에 대하여 논하며, hybrid-clustering 기술을 제안한다.