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( Fatemeh Elham Mahjoub ),( Nasim Zahedi ),( Bahar Ashjai ),( Mohammad Taghi Haghi Ashtiani ),( Fatemeh Farahmand ),( Maryam Monajemzadeh ),( Leila Kashi ),( Heshmat Iranikhah ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.5
Background/Aims: Calprotectin is a 36.5 kD calcium and zinc binding protein in the S100 protein family. Fecal calprotectin levels are elevated in patients with inflammatory bowel disease and some other gastrointestinal disorders such as colorectal carcinoma. We decided to evaluate the fecal calprotectin level to see if it was able to distinguish between functional and organic causes of constipation. Methods: Seventy-six children aged 1 to 120 months that all underwent deep rectal mucosa biopsies at Children Medical Center from November 2010 till September 2011 were recruited. Nineteen cases were diagnosed as Hirschsprung`s disease and 57 of the patients had nerve ganglion cells in their biopsies. Calprotectin concentration was analyzed by the ELISA method. Results: Although there was a significant difference between the median of the two groups (p=0.036), the median was not above the predetermined cutoff value of 50 μg/g. Conclusions: We propose that fecal calprotectin, using the above cutoff value, has limited value in differentiating functional constipation from Hirschsprung`s disease. (Korean J Gastroenterol 2013;62:288-291)
Virulence Factors of Staphylococcus aureus Isolates in an Iranian Referral Children’s Hospital
Farah Sabouni,Shima Mahmoudi,Abbas Bahador,Babak Pourakbari,Reihaneh Hosseinpour Sadeghi,Mohammad Taghi Haghi Ashtiani,Bahram Nikmanesh,Setareh Mamishi 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.2
Objectives: The clinical importance of Staphylococcus aureus (S. aureus) is attributed to notable virulence factors, surface proteins, toxins, and enzymes as well as the rapid development of drug resistance. The aim of this study was to compare the occurrence of virulence factors produced by S. aureus strains isolated from children in an Iranian referral children’s hospital. Methods: The presence of genes encoding for the enterotoxins A (sea), B (seb), C (sec), D (sed ), TSST-1 (tsst), exfoliative toxin A (eta), and exfoliative toxin B (etb) were detected by Multiplex polymerase chain reaction (PCR) using specific primers. In addition, the standardized Kirby-Bauer disc-diffusion method was performed on Mueller-Hinton agar. Results: In total, 133 S. aureus isolates were obtained from different patients. Of these S. aureus isolates, 64 (48%) were methicillin-resistant S. aureus (MRSA), and all of these tested positive for the mecA gene. Regarding the classical enterotoxin genes, sea gene (40.6%) was the most prevalent followed by seb (19.6%), tsst (12.8%), eta (11.3%), etb (9%), sed (4.5%), and sec (3%). Among methicillin-susceptible S. aureus (MSSA) isolates, seb and tsst were the more prevalent toxins in comparison with MRSA isolates (p < 0.05), while the frequency of sea, sed, eta, and etb genes were higher among MRSA isolates (p > 0.05). Conclusion: In our study enterotoxin A was produced by 40.6% of the isolates (48% from MRSA and 33% from MSSA isolates) which was higher than in previous reports. According to our results, strict hygiene and preventative measures during food processing are highly recommended.