The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

( Mohammad H Farzaei ),( Roodabeh Bahramsoltani ),( Mohammad Abdollahi ),( Roja Rahimi ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.4

Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process that may occur within the peripheral or central nervous systems and plays a principal role in the etiology of IBS symptoms. The pharmacological studies on selective drugs based on targeting specific ligands can provide novel therapies for modulation of persistent visceral hyperalgesia. The current paper reviews the cellular and molecular mechanisms underlying therapeutic targeting for providing future drugs to protect or treat visceroperception and pain sensitization in IBS patients. There are a wide range of mediators and receptors participating in visceral pain perception amongst which substances targeting afferent receptors are attractive sources of novel drugs. Novel therapeutic targets for the management of VH include compounds which alter gut-brain pathways and local neuroimmune pathways. Molecular mediators and receptors participating in pain perception and visceroperception include histamine-1 receptors, serotonin (5-hydrodytryptamine) receptors, transient receptor potential vanilloid type I, tachykinins ligands, opioid receptors, voltage-gated channels, tyrosine receptor kinase receptors, protease-activated receptors, adrenergic system ligands, cannabinoid receptors, sex hormones, and glutamate receptors which are discussed in the current review. Moreover, several plant-derived natural compounds with potential to alleviate VH in IBS have been highlighted. VH has an important role in the pathology and severity of complications in IBS. Therefore, managing VH can remarkably modulate the symptoms of IBS. More preclinical and clinical investigations are needed to provide efficacious and targeted medicines for the management of VH.

Comparison of mice’ sperm parameters exposed to some hazardous physical agents

Mohammad-Bagher Abdollahi,Somayeh Farhang Dehghan,Faezeh Abasi Balochkhaneh,Manouchehr Ahmadi Moghadam,Hamzeh Mohammadi 환경독성보건학회 2021 환경독성보건학회지 Vol.36 No.3

The present study was aimed to compare the effects of exposure to noise, vibration, lighting, and microwave on male mice’ sperm parameters. The mice were randomly assigned to five groups of eight, which comprised of the unexposed group and exposure groups including the lighting (1000 lux), noise (100 dB(A)), vibration (acceleration of 1.2 m/s²) and microwave (power density of 5 watts). The exposure groups were subjected to the four agents for 8 hours a day, 5 days a week during a 2-week period. Semen analysis were done according to World Health Organization guidelines. The highest significant mean difference in sperm count (-1.35×10<SUP>6</SUP>/mL) had being observed between the microwave group and the control one (P=0.001). The highest difference in immotile percent (25.88 %) had being observed between the noise group and the control one (P=0.001). The highest difference in normal morphology (-27.06 %) observed between the lighting exposure group and the control group (P=0.001). The four agents can cause changes in different sperm parameters, however for definite conclusion; more laboratory and field studies are required. In total, exposure to microwave has had the greatest effect on sperm count and exposure to light has had the greatest effect on normal morphology and non-progressive motility. Moreover, exposure to noise has had the greatest effect on progressive motility and immotile percent, respectively.

FAS-670A>G gene polymorphism and the risk of allograft rejection after organ transplantation: a systematic review and meta-analysis

Mohammad Masoud Eslami,Ramazan Rezaei,Sara Abdollahi,Afshin Davari,Mohammad Ahmadvand 대한혈액학회 2021 Blood Research Vol.56 No.1

The association between the risk of allograft rejection after organ transplantation and FAS gene polymorphism has been evaluated previously. However, inconsistent results have been reported. Hence, we conducted the most up-to-date meta-analysis to evaluate this association. All eligible studies reporting the association between FAS-670A>G polymorphism and the risk of allograft rejection published up to December 2019 were extracted using a comprehensive systematic database search in the Web of Science, Scopus, and PubMed. The pooled odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated to determine the association strength. This meta-analysis included six case-control studies with 277 patients who experienced allograft rejection and 1,001 patients who did not experience allograft rejection (controls) after organ transplantation. The overall results showed no significant association between FAS-670A>G polymorphism and the risk of allograft rejection in five genetic models (dominant model: OR=0.81, 95% CI=0.58‒1.12; recessive model: OR=0.10, 95% CI=0.80‒1.53; allelic model: OR=0.96, 95% CI=0.79‒1.18; GG vs. AA: OR=0.92, 95% CI=0.62‒1.36; and AG vs. AA: OR=0.75, 95% CI=0.52‒1.08). Moreover, subgroup analysis according to ethnicity and age did not reveal statistically significant results. Our findings suggest that FAS-670A>G polymorphism is not associated with the risk of allograft rejection after organ transplantation.

NUMERICAL RANGE AND SOT-CONVERGENCY

ABDOLLAHI, ABDOLAZIZ,HEYDARI, MOHAMMAD TAGHI Korean Mathematical Society 2015 대한수학회논문집 Vol.30 No.3

A sequence of composition operators on Hardy space is considered. We prove that, by numerical range properties, it is SOT-convergence but not converge.

Gastrointestinal Cancer Incidence in East Azerbaijan, Iran: Update on 5 Year Incidence and Trends

Somi, Mohammad Hossein,Golzari, Mehrad,Farhang, Sara,Naghashi, Shahnaz,Abdollahi, Leila Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

Background: A cancer registry program has been established in East Azerbaijan and this has emphasized the importance of cancers of gastrointestinal tract in this region. The aim of the present pathology-based cancer registry report is to renew epidemiologic aspects of gastrointestinal tract cancers and estimate recent trends. Materials and Methods: A survey team reviewed and collected all records of cancer cases from all referral and valid pathology laboratories of East Azerbaijan province during September 2007-2011. Crude rates, age-specific rates of cancer incidence and annual percent change were calculated. Results: The total newly diagnosed cancer cases (n=6,889)comprised 4,341 males (63.0%) and 2,540 females (36.9%). Gastric cancer was the most common GI tract cancer with an ASR (per $10^5$) of 23.1 for males and 7.69 for females. The ASRs for esophageal and colorectal cancers were 9.69 and 11.2 in males and 7.35 and 8.93 in females. Trend analysis showed a significant decline for esophageal cancer and increasing incidence for colorectal cancer in females. Conclusions: The prevalence of gastric cancer is high in East Azerbaijan province of Iran. This pathology based cancer registry showed an ascending trend for colorectal cancer and decreasing trend for esophageal cancer in females during 2007-2011.

Improved antifouling and self-cleaning ability of PVDF ultrafiltration membrane grafted with polymer brushes for oily water treatment

Sakineh Pourziad,Mohammad Reza Omidkhah,Mahdi Abdollahi 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.83 No.-

This study focuses on the modification of commercial polyvinylidenefluoride (PVDF) membranes usingsurface-initiated atom transfer radical polymerization (SI-ATRP) method. Poly(N-isopropylacrylamide)(PNIPAAm) was grafted from PVDF surface and then PEGMA was grafted onto the PVDF-g-PNIPAAmmembrane. The aim of the research was to prepare membranes that simultaneously have antifouling andself-cleaning properties. PNIPAAm (lower block) was grafted to give the membrane temperaturesensitive property and PPEGMA (upper block) was used to improve hydrophilicity. Morphology,topography and chemical composition of the modified membranes were completely characterized. Antifouling and cleaning ability of modified membranes were investigated using synthetic oily water. Moreover, the role of PEGMA polymerization time on the membrane performance was examined. PNIPAAm-b-PPEGMA modified membrane achieved 64% decrease in fouling ratio compared tounmodified PVDF membrane at best condition. Theflux recovery was 99.1% for modified membraneat this condition. Furthermore, the unmodified PVDF membrane showed 91.1% oil rejection; while themodified membrane could reject 98.2% oil molecules. Thefinalflux of all modified membranes werehigher than unmodified membrane. These results indicated that PNIPAAm-b-PPEGMA modifiedmembranes have excellent fouling resistance and self-cleaning ability.

Ethical Priority Setting for Successful Publishing by Iranian Scientists

Tina Didari,Mohammad Abdollahi 대한의학회 2018 Journal of Korean medical science Vol.33 No.49

In 2016, BioMed Central (BMC), a leading open-access publisher, retracted 58 Iranian articles due to alleged peer review and authorship manipulations.1 The next year, PubMed Central (PMC) reevaluated and discontinued archiving of 14 Iranian journals, which failed to meet the “scientific and editorial standards” of the global digital repository.2 Later on, Elsevier retracted 26 Iranian articles, which were mostly authored by the same physicist, due to “peer-review manipulations” and “unexplained authorship irregularities,”3 and Wiley pulled 13 articles of an Iranian ichthyologist over “concerns about faked peer review.”4 Although such unfortunate incidents take place globally, Iranian scholars could escape the latest grim allegations by adhering to the global and local editorial guidance.

In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan

Mehrdad Ghorbanlou,Fatemeh Moradi,Mohammad Hassan Kazemi-Galougahi,Maasoume Abdollahi 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1

Morphologic changes in the brain through aging, as a physiologic process, may involve a wide range of variables including ventricular dilation, and sulcus widening. This study reports normal ranges of these changes as standard criteria. Normal brain computed tomography scans of 400 patients (200 males, 200 females) in every decade of life (20 groups each containing 20 participants) were investigated for subcortical/cortical atrophy (bicaudate width [BCW], third ventricle width [ThVW], maximum length of lateral ventricle at cella media [MLCM], bicaudate index [BCI], third ventricle index [ThVI], and cella media index 3 [CMI3], interhemispheric sulcus width [IHSW], right hemisphere sulci diameter [RHSD], and left hemisphere sulci diameter [LHSD]), ventricular symmetry. Distribution and correlation of all the variables were demonstrated with age and a multiple linear regression model was reported for age prediction. Among the various parameters of subcortical atrophy, BCW, ThVW, MLCM, and the corresponding indices of BCI, ThVI, and CMI3 demonstrated a significant correlation with age (R2≥0.62). All the cortical atrophy parameters including IHSW, RHSD, and LHSD demonstrated a significant correlation with age (R2≥0.63). This study is a thorough investigation of variables in a normal brain which can be affected by aging disclosing normal ranges of variables including major ventricular variables, derived ventricular indices, lateral ventricles asymmetry, cortical atrophy, in every decade of life introducing BW, ThVW, MLCM, BCI, ThVI, CMI3 as most significant ventricular parameters, and IHSW, RHSD, LHSD as significant cortical parameters associated with age.

Different Anatomical Distribution of Basal Cell Carcinoma Subtypes in Iranian Population: Association between Site and Subtype

( Alireza Ghanadan ),( Pejman Abdollahi ),( Mehrshad Rabet ),( Zahra Naraghi ),( Mohammad Amin Abbasi ),( Homayun Moslehi ),( Ata Abbasi ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.5

Background: Basal cell carcinoma (BCC) is the most common type of human cancer. Despite the high prevalence of these tumors, there is a lack of reliable epidemiological data in some regions including Iran. Objective: To assess the relationship between BCC subtypes and anatomical distribution in the Iranian population. Methods: There were 876 patients with a single BCC enrolled in this study (March 2007 to March 2010; Razi Dermatology Center, Tehran, Iran). Results: Among 876 patients, 544 were males and 332 females. Of the lesions, 43% were nodular, 32.4% mixed type, 3% superficial and rest of other subtypes. In the lesion location, 58.2% were on the face, 29.2% on scalp, 6.2% on ears, 2.3% on neck, 1.7% on trunk and 1.3% on the extremities. There was no significant difference between male and female in the BCC subtypes, but anatomical distribution of the tumor was different (p=0.002). Most of the trunk- arising BCCs were superficial, and most of the facial BCCs were nodular subtype. Also, most of the BCC subtypes occurred in patients between 40 to 80 years old and mostly on the face and scalp (p=0.04). However, superficial BCCs mostly occurred in younger patients over others (p=0.001). Conclusion: Subtype is associated with a site, independent of gender or age. Also BCCs occurring on the trunk are mostly of the superficial subtype. (Ann Dermatol 26(5) 559∼563, 2014)

A Multi-Layer Architecture for Intrusion Tolerant Web Services

Zahra Aghajani Kalkhoran,Mohammad Abdollahi Azgomi 보안공학연구지원센터(IJUNESST) 2008 International Journal of u- and e- Service, Scienc Vol.1 No.1