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Microwave-assisted Weak Acid Hydrolysis of Proteins
( Miyeong Seo ),( Jinhee Kim ),( Sehwan Park ),( Ji-hye Lee ),( Taehee Kim ),( Jihyeon Lee ),( Jeongkwon Kim ) 한국질량분석학회 2012 Mass spectrometry letters Vol.3 No.2
Myoglobin was hydrolyzed by microwave-assisted weak acid hydrolysis with 2% formic acid at 37 oC, 50 oC, and 100 oC for 1 h. The most effective hydrolysis was observed at 100 oC. Hydrolysis products were investigated using matrixassisted laser desorption/ionization time-of-flight mass spectrometry. Most cleavages predominantly occurred at the C-termini of aspartyl residues. For comparison, weak acid hydrolysis was also performed in boiling water for 20, 40, 60, and 120 min. A 60- min weak acid hydrolysis in boiling water yielded similar results as a 60-min microwave-assisted weak acid hydrolysis at 100 oC. These results strongly suggest that microwave irradiation has no notable enhancement effect on acid hydrolysis of proteins and that temperature is the major factor that determines the effectiveness of weak acid hydrolysis.
Seunghui Lee*,Miyeong Lee*,Sangdon Kwan,Soohyung Kim,Ki Bum Park,Oh Kyoung Kwon,Ji Yeon Park 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.6
Purpose: Among patients with gastric cancer who underwent radical gastrectomy, the proportion of patients aged ≥80 years has increased. This study aimed to evaluate surgical outcomes and survival of patients aged ≥80 years who underwent curative resection for gastric cancer and identify independent factors that affect postoperative survival. Methods: This retrospective study enrolled 1,066 patients aged ≥65 years with gastric cancer who underwent curative resection between January 2014 and December 2018 at a single institution. They were divided into those aged ≥80 years (old-elderly group) and 65–79 years (young-elderly group). Their clinicopathological characteristics and surgical outcomes were compared. Results: Of the 1,066 patients, 136 (12.8%) were 80 years or older. Higher American Society of Anesthesiologists (ASA) physical status classification and more advanced cancers were observed in the old-elderly group than in the young-elderly group. No significant difference in postoperative complications was found between the groups. At a median follow-up of 49.1 months, the 5-year overall survival rate after surgery for the old-elderly group was lower than that for the young-elderly group (75.6% vs. 87.0%, P < 0.001). However, the 5-year disease-specific survival rate was comparable between the groups (90.1% vs. 92.2%, P = 0.324). ASA physical status classification, pathologic stage, and surgical approach were independent predictors of overall survival. Conclusion: Old-elderly patients aged ≥80 years had comparable postoperative outcomes and disease-specific survival to the young-elderly group, suggesting that curative gastrectomy can be considered a viable option for octogenarian patients with gastric cancer.
데이터베이스에서 개인정보보호를 위한 정책기반 쿼리 변환기 설계 및 구현
김미영 ( Miyeong Kim ),이영록 ( Younglok Lee ),이형효 ( Hyunghyo Lee ),김용민 ( Bongnam Noh ) 한국정보처리학회 2008 한국정보처리학회 학술대회논문집 Vol.15 No.1
인터넷으로 대표되는 정보통신망 및 컴퓨터를 이용한 개인 정보 수집과 활용이 일반화됨에 따라 수집된 개인정보의 불법적인 접근 유출 사례가 증가하고 있다. 현재의 개인정보 이용 환경은 데이터 접근 시 사용자의 질의 내용과 그에 대한 결과가 그대로 노출되어 사용자의 프라이버시를 침해하는 문제를 안고 있다. 본 논문에서는 데이터베이스에서 개인정보보호를 위해 접근제어 정책 기반 쿼리 처리 시스템인 보안 게이트웨이를 설계하고 구현한다. 이 시스템은 클라이언트가 TDS 프로토콜을 이용하여 DBMS에 접근해 정보를 요청할 때 보안 정책을 반영함으로써 단순한 차단은 물론 변환된 쿼리 응답을 한다. 본 시스템은 불법적인 접근에 대한 제어는 물론이고, 정당한 인증자의 실수나 고의적인 개인정보 유출로 인한 경제적, 사회적 손실을 방지할 수 있다. 또한 주민등록번호 등 보안 대상 정보를 제외한 기타 정보에 대한 접근을 허용함으로써 데이터베이스 가용성을 보장한다.
Park, Miyeong,Jeong, Sang-Ho,Lee, Young-Joon,Park, Ji-Ho,Choi, Sang-Kyung,Hong, Soon-Chan,Jung, Eun-Jung,Ju, Young-tae,Jeong, Chi-Young,Lee, Jeong-Hee,Ha, Woo-Song The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.1
An 84-year-old man was diagnosed with two synchronous adenocarcinomas, a Borrmann type IV advanced gastric adenocarcinoma in his antrum and a well-differentiated Borrmann type I carcinoma on the anterior wall of the higher body of his stomach. Pre-operatively, computed tomography of the abdomen revealed the presence of advanced gastric cancer with peri-gastric and para-aortic lymph node (LN) metastasis. He planned for palliative total gastrectomy owing to the risk of obstruction by the antral lesion. We performed a frozen biopsy of a para-aortic LN during surgery and found that the origin of the para-aortic LN metastasis was from undiagnosed prostate cancer. Thus, we performed radical total gastrectomy and D2 LN dissection. Post-operatively, his total prostate-specific antigen levels were high (227 ng/mL) and he was discharged 8 days after surgery without any complications.
Effects of Oral Intake of Kimchi-Derived Lactobacillus plantarum K8 Lysates on Skin Moisturizing
( Hangeun Kim ),( Hye Rim Kim ),( Bong Jun Jeong ),( Seung Su Lee ),( Tae Rahk Kim ),( Ji Hye Jeong ),( Miyeong Lee ),( Sinai Lee ),( Jong Suk Lee ),( Dae Kyun Chung ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.1
Skin is the soft outer covering of vertebrates that provides protection from pathogenic infection, physical damage, or UV irradiation, and controls body temperature and water content. In this study, we examined the effects of oral intake of kimchi-derived Lactobacillus plantarum K8 lysates on skin moisturizing. In an in vitro study, we observed that the hyaluronic acid content increased in HaCaT cells treated with L. plantarum K8 lysates. Oral administration of L. plantarum K8 lysates effectively attenuated the horny layer formation and decreased epidermal thickening in DNCB-treated SKH-1 hairless mice skin. The damage to barrier function was reduced after 8 weeks of oral administration of L. plantarum K8 lysates as compared with that in the atopic dermatitis mice. For the test with volunteers, we manufactured experimental candy containing 2.1% L. plantarum K8 lysates, while control candy did not contain bacterial lysate. A significant increase in hydration in the experimental candy-administered group as compared with the control candy-administered group was observed on the face after 4 and 8 weeks, and on the forearm after 4 weeks. Decreases in horny layer thickness and TEWL value were observed on the face and forearm of the experimental group. Together, the in vitro cell line and in vivo mouse studies revealed that L. plantarum K8 lysates have a moisturizing effect. A clinical research study with healthy volunteers also showed an improvement in barrier repair and function when volunteers took L. plantarum K8 lysates-containing candy. Thus, our results suggest that L. plantarum K8 lysates may help to improve skin barrier function.
Joongwon Lee,Seik Park,Haikyung Seo,Miyeong Kim,Simoon Kim,Junhwa Chi,Kitae Kim 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.5
The integrated gasification combined cycle (IGCC) system is well known for its high efficiency compared with that of other coal fueled power generating systems. In this study, gasification using different types of burners with different oxygen supply angles in a bench-scale entrained flow gasifier was investigated. The effects of the oxygen gas supply angle of the coal burner and resulting oxygen supply location in the gasifier on the syngas composition and temperature of the gasifier were experimentally examined. These changes had a significant influence on the syngas composition of the final stream, carbon conversion, and efficiencies. According to the experimental results, the models using the Aspen Plus process simulator were positioned to define the effects of the experimental parameters and to find the optimum operating conditions in the bench gasifier facility.
강미영 ( Miyeong Kang ),이은옥 ( Eunok Lee ),박우창 ( Uchang Park ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.2
본 연구에서는 내용 기반의 텍스타일 이미지 검색 시스템을 구축하였다. 텍스타일 이미지에 대한 색상, 질감, 모양 특성 추출 조합을 각각 혹은 가중치를 이용한 방법으로 검색한다. 검색은 사용자 인터페이스에서 오라클 데이터베이스 시스템에서 제공되는 이미지의 색상, 질감 특성 값에 대한 검색과 결과 피드백을 보면서 진행된다. 또 검색 대상 이미지들을 유사도에 따라 다차원 비례법에 의하여 2차원 화면에 클러스터링하여 전체 이미지의 군집화 특성을 쉽게 파악할 수 있는 기능을 구현하였다.
간호사 맞춤 핸드크림 사용이 손 피부 보습에 미치는 효과
박미영 ( Park Miyeong ),이미라 ( Lee Mira ),정진희 ( Jung Jinhee ),황혜영 ( Hwang Hyeyoung ),박동순 ( Park Dongsoon ) 서울대학교 간호과학연구소 2020 간호학의 지평 Vol.17 No.2
Purpose: This study sought to verify the effectiveness of the Nurse Hand Cream developed to protect the skin of the hands of nurses damaged by frequent hand hygiene. Methods: A randomized controlled trial was conducted that compared the hand skin moisture content of subjects using the Nurse Hand Cream that had been developed for nurses with that of the other hand cream. Results: After applying the hand cream, the subjects’ skin moisture content were measured using a skin moisture measuring device; the moisture content of the experimental group significantly increased compared with the control group (p<.001). In particular, as a result of the second experiment that involved the four-time performance of hand hygiene every 30 minutes for two hours, the skin moisture content of the experimental group significantly increased compared with the control group, and 84.4% of the experimental group maintained a normal or higher skin moisture content. Conclusion: The hand cream for nurses was statistically confirmed to strengthen the moisturizing power and prevention of skin moisture loss compared with the other hand cream.