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Woo, Je Moon,Shin, Da-Yong,Lee, Sung Ju,Joe, Yeonsoo,Zheng, Min,Yim, Jin Ho,Callaway, Zak,Chung, Hun Taeg Molecular Vision 2012 Molecular vision Vol.18 No.-
<P><B>Purpose</B></P><P>To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells.</P><P><B>Methods</B></P><P>Effective concentrations and toxicities of curcumin were determined after 3 h of curcumin treatment with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Confluent human retinal pigment epithelium cell lines (ARPE-19) were preincubated with curcumin and oxidatively challenged with H<SUB>2</SUB>O<SUB>2</SUB>. HO-1 expression was determined with western blot analysis. To confirm the protective role of HO-1 in oxidative stress, small interfering RNA (siRNA) against HO-1 or inhibitor of HO-1 was treated with curcumin in retinal pigment epithelium cells. Intracellular levels of reactive oxygen species (ROS) were measured with flow cytometry and confocal microscopy. Apoptosis was evaluated with Annexin V-fluoroscein isothiocyanate staining.</P><P><B>Results</B></P><P>Curcumin had little cytotoxicity at concentrations less than 30 μM, and HO-1 expression was the highest at the 15 μM concentration. At this concentration, curcumin also increased the cytoprotective effect against the oxidative stress of H<SUB>2</SUB>O<SUB>2</SUB> through the reduction of ROS levels in human retinal pigment epithelial cells. Curcumin’s effect on the reduction of ROS was mediated by the increase in HO-1 expression.</P><P><B>Conclusions</B></P><P>Curcumin upregulated the oxidative stress defense enzyme HO-1 and may protect human retinal pigment epithelial cells against oxidative stress by reducing ROS levels.</P>
이민수,조숙행,한선호,서광윤,이병윤 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.2
To provide data on the clinical issues related to the birth order and other characteristic background in epilepsy, 331 idiopathic epileptic patients were evaluated and analyzed phenomenologically. The patients had been treated at the neuropsychiatric department of the Korea University Hospital during 1974 to 1980. The age at onset ranged from 1 to 45 years, with the mean age of 16.65 years. Males were 1.36 times more than females. Seventeen (5.13%) of the subjects had the family history of epilepsy. Attacks in the daytime only occurred in 67.67% (N=224) of the subjects, while 23.56% (N=78) had their seizures only at night, and 8.77% (N=20) had their seizures both at daytime and night. Grand mal was the most frequent type of seizure, followed by psychometer and petit mal. There was a higher incidence among the first born than the subsequent siblings and the children born second had a somewhat higher frequency of epilepsy than the subsequent children.
Joe, Min-Ho,Jeong, Hyun-Tak,Lee, Hyung-Min,Park, Hae-Jun,Kim, Dong-Ho,Park, Don-Hee,Bai, Suk Hindawi Limited 2017 Journal of nanomaterials Vol.2017 No.-
<P>This study investigates the phytosynthesis, characterization, and antibacterial efficacy of silver and gold nanoparticles (NPs) produced using the hot water extract of mixed woodchip powder. The woodchip extract (WCE) was successfully used as both a reducing and stabilizing agent for the phytosynthesis of both crystalline metal NPs. The effects of different physicochemical factors affecting the formation of the metal NPs including reaction pH, concentration of the precursor metal salts, amount of WCE, and external energy input were evaluated. The characterization of the metal NPs was performed by transmission electron microscopy, selected area electron diffraction (SAED), energy dispersive X-ray (EDX) spectroscopy, and X-ray diffraction (XRD) pattern analysis. In addition, the antibacterial efficacy of the phytosynthesized NPs was measured. The AgNPs showed clear antibacterial activity against four representative bacterial strains. However, the AuNPs did not exhibit bactericidal activity, probably due to their surface modifications and relatively large size. These results suggest that the phytosynthesis of the metal NPs using WCE is highly efficient, and its convenience makes it suitable for use in large-scale production.</P>
Joe, Min-Ho,Kim, Dong-Ho,Choi, Dae Seong,Bai, Suk The Korean Society for Microbiology and Biotechnol 2018 한국미생물·생명공학회지 Vol.46 No.4
In this study, a novel microalgal strain, Desmodesmus sp. KAERI-NJ5, was isolated, identified, and evaluated as a candidate for biodiesel feedstock. In a preliminary study, the effects of four general microalgal growth factors, including temperature, pH, light intensity, and concentration of nitrogen source ($KNO_3$), on the microalgal photoautotrophic growth were evaluated. With the exception of light intensity, the growth factors needed to be optimized for the microalgal biomass production. Optimization was done using response surface methodology. The optimal conditions for biomass production were pH 6.54, $27.66^{\circ}C$, and 0.52 g/l $KNO_3$. The biomass production at the optimal conditions was 1.55 g/l, which correlated well with the predicted value of 1.5 g/l. The total lipid and fatty acid methyl ester contents of the cells grown at the optimal conditions were 49% and 21.2% of cell dry weight, respectively. To increase the lipid content of the biomass, microalgae were challenged by nitrogen starvation. Enhancement of total lipid and fatty acid content up to 52.02% and 49%, respectively, were observed. Lipid analysis of the nitrogen-starved cells revealed that C16 and C18 species accounted for 95.9% of the total fatty acids. Among them, palmitic acid (46.17%) and oleic acid (39.43%) dominantly constituted the algal fatty acids. These results suggest Desmodesmus sp. KAERI-NJ5 as a promising feedstock for biodiesel production.
Genome-Wide Response of Deinococcus radiodurans on Cadmium Toxicity
( Min Ho Joe ),( Sun Wook Jung ),( Seong Hun Im ),( Sang Yong Lim ),( Hyun Pa Song ),( Oh Suk Kwon ),( Dong Ho Kim ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.4
Deinococcus radiodurans is extremely resistant to various genotoxic conditions and chemicals. In this study, we characterized the effect of a sublethal concentration (100 μM) of cadmium (Cd) on D. radiodurans using a whole-genome DNA microarray. Time-course global gene expression profiling showed that 1,505 genes out of 3,116 total ORFs were differentially expressed more than 2-fold in response to Cd treatment for at least one timepoint. The majority of the upregulated genes are related to iron uptake, cysteine biosynthesis, protein disulfide stress, and various types of DNA repair systems. The enhanced upregulation of genes involved in cysteine biosynthesis and disulfide stress indicate that Cd has a high affinity for sulfur compounds. Provocation of iron deficiency and growth resumption of Cd-treated cells by iron supplementation also indicates that CdS forms in iron-sulfur-containing proteins such as the [Fe-S] cluster. Induction of base excision, mismatch, and recombinational repair systems indicates that various types of DNA damage, especially base excision, were enhanced by Cd. Exposure to sublethal Cd stress reduces the growth rate, and many of the downregulated genes are related to cell growth, including biosynthesis of cell membrane, translation, and transcription. The differential expression of 52 regulatory genes suggests a dynamic operation of complex regulatory networks by Cd-induced stress. These results demonstrate the effect of Cd exposure on D. radiodurans and how the related genes are expressed by this stress.
Ho-Jung Kang,Sung-Ho Bae,Min-Kyu Jeong,Sung-Min Joe,Byung-Gook Park,Jong-Ho Lee IEEE 2015 IEEE electron device letters Vol.36 No.1
<P>A new method to extract the interface trap density (N<SUB>it</SUB>) on the surface of the Si region between adjacent wordlines (WLs-called space region) in NAND flash devices is presented in this letter. The N<SUB>it</SUB> is successfully extracted by applying charge pumping (CP) method, TCAD simulation, and modified equations. The CP current I<SUB>CP</SUB> of single WL and electrically tied two WLs are measured using fixed-base CP measurement as a function of pass bias. In addition, an effective space area for CP is extracted by TCAD simulation, and the equation, which is used to extract N<SUB>it</SUB>, is modified to extract separated N<SUB>it</SUB>s in the channel and the space regions. We confirm that our method is accurate by comparing the measured I<SUB>CP</SUB> with the calculated one.</P>
Min-Kyu Jeong,Ho-Jung Kang,Sung-Min Joe,Sung-Kye Park,Byung-Gook Park,Jong-Ho Lee IEEE 2015 IEEE electron device letters Vol.36 No.6
<P>The trap density (N<SUB>t</SUB>) in nitride storage layer of 3-D NAND flash memory cells with tube-type channel structure is extracted. To extract N<SUB>t</SUB> profile in the nitride layer, retention characteristics, and ac-transconductance (g<SUB>m</SUB>) method are used, and equations are derived in cylindrical coordinate. The N<SUB>t</SUB> profile at E - E<SUB>T</SUB> smaller than 1 eV is extracted using retention characteristics of the cells measured at high temperature. The peak value of extracted N<SUB>t</SUB> is ~1 × 1019 cm<SUP>-3</SUP> eV<SUP>-1</SUP> at a E<SUB>C</SUB> - E<SUB>T</SUB> of 0.93 eV. AC-g<SUB>m</SUB> method is used to profile the N<SUB>t</SUB> in E - E<SUB>T</SUB> higher than 1 eV. Extracted N<SUB>t</SUB> profile shows a reasonable continuity between both approaches and looks like a Gaussian function.</P>
( Min-ho Joe ),( Dong-ho Kim ),( Dae Seong Choi ),( Suk Bai ) 한국미생물 · 생명공학회 2018 한국미생물·생명공학회지 Vol.46 No.4
In this study, a novel microalgal strain, Desmodesmus sp. KAERI-NJ5, was isolated, identified, and evaluated as a candidate for biodiesel feedstock. In a preliminary study, the effects of four general microalgal growth factors, including temperature, pH, light intensity, and concentration of nitrogen source (KNO3), on the microalgal photoautotrophic growth were evaluated. With the exception of light intensity, the growth factors needed to be optimized for the microalgal biomass production. Optimization was done using response surface methodology. The optimal conditions for biomass production were pH 6.54, 27.66℃, and 0.52 g/l KNO3. The biomass production at the optimal conditions was 1.55 g/l, which correlated well with the predicted value of 1.5 g/l. The total lipid and fatty acid methyl ester contents of the cells grown at the optimal conditions were 49% and 21.2% of cell dry weight, respectively. To increase the lipid content of the biomass, microalgae were challenged by nitrogen starvation. Enhancement of total lipid and fatty acid content up to 52.02% and 49%, respectively, were observed. Lipid analysis of the nitrogen-starved cells revealed that C16 and C18 species accounted for 95.9% of the total fatty acids. Among them, palmitic acid (46.17%) and oleic acid (39.43%) dominantly constituted the algal fatty acids. These results suggest Desmodesmus sp. KAERI-NJ5 as a promising feedstock for biodiesel production.