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참깨粕 蛋白質과 Phytate의 溶解度에 의한 pH와 鹽類의 影響
崔淸,趙永濟,孫圭睦,林聖一,李宇濟 영남대학교 자원문제연구소 1989 資源問題硏究 Vol.8 No.-
The solubilities of phytate and protein in defatted sesame meal extracts as influenced by salts were measured. Optimum extraction conditions as influenced by only pH without salt were identified as: extraction of defatted sesame meal at pH 12.0 and precipitation of protein at pH5.0. Crude protein precipitation was better in higher pH. The protein extraction was more effective with the solution containing Na2C03 under the pH 8. The results showed that papain treatment increased the rates of the protein and phytate solubility when those values were compared to the salts treatment. Glutamic acid contents of water soluble protein and salts soluble protein were 33.3% and 20.0% respectively. Both proteins contained relatively high levels of essential amino acid.
( Jae Yun Han ),( Sang Kyu Lee ),( Ji Hye Yang ),( Sun Ju Kim ),( Ju Hee Sim ),( Mi Gwang Kim ),( Tae Cheon Jeong ),( Sae Kwang Ku ),( Ll Je Cho ),( Sung Hwang Ki ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Background: Alcoholic steatosis is the earliest and most common liver disease, and may precede the onset of more severe forms of liver injury. Methods :The effect of Korean Red Ginseng extract (RGE) was tested in two murine models of ethanol(EtOH)-feeding and EtOH-treated hepatocytes. Results: Blood biochemistry analysis demonstrated that RGE treatment improved liver function. Histo-pathology and measurement of hepatic triglyceride content verified the ability of RGE to inhibit fat accumulation. Consistent with this, RGE administration downregulated hepatic lipogenic gene induction and restored hepatic lipolytic gene repression by EtOH. The role of oxidative stress in the pathogenesis of alcoholic liver diseases is well established. Treatment with RGE attenuated EtOH-induced cytochrome P450 2E1, 4-hydroxynonenal, and nitrotyrosine levels, Alcohol consumption also decreased phosphor-ylation of adenosine monophosphate-activated protein kinase, which was restored by RGE. Moreover, RGE markedly inhibited fat accumulation in EtOH-treated hepatocytes, which correlated with a decrease in sterol regulatory element-binding protein-1 and a commensurate increase in sirtuin 1 and peroxisome proliferator-activated receptor-a expression. Interestingly, the ginsenosides RB2 and Rd, but not Rb1, significantly inhibited fat accumulation in hepatocytes. Conclusion: These results demonstrate that RGE and its ginsenoside components inhibit alcoholic stea-tosis and liver injury by adenosine monophosphate-activated protein kinase/sirtuin 1 actication both in vivo and in vitro, suggesting that RGE may have a potential to treat alcoholic liver disease. Copyrightⓒ2014. The Korean Society of Ginseng. Published by Elsevier. All rights reserved.