비정형 향정신병약물을 투여 중인 정신분열병 환자의 주관적 삶의 질 : 정신병리, 약물 부작용 및 약물에 대한 주관적 반응과의 관련성

김종훈,윤정희,이자영,노경희,홍성극,윤세창,강웅구,김용식 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : The purpose of this study was to evaluate the characteristics of psychopathology, adverse drug effects, and Subjective response to drugs that have a significant impact on the subjective quality of life in schizophrenic patients receiving atypical antipsychotics. Methods : One hundred and one schizophrenic patients, who were receiving maintenance treatment with atypical antipsychotics, were evaluated. Subjective quality of life was assessed using the standardized Korean modification of a self-rating scale to measure subjective well-being under neuroleptics (KmSWN). Patients' psychopathology was evaluated using the Positive and Negative Syndrome Scale. Adverse effects and subjective response to drug were evaluated using the Liverpool University Neuroleptic Side Effect Rating Scale and the Drug Attitude Inventory-10, respectively. Correlation analysis and stepwise multiple regression analysis were conducted. Results : In psychopathology, the severity of depression and anxiety showed the most significant correlation with the score ofKmSWN. In adverse drug effects, the severity of psychic side effect and extrapyramidal side effect showed the most significant correlation with the score ofKmSWN. Regarding subjective response to drug, significant correlation was observed between the severity of subjective negative response and the score of KmSWN. Stepwise multiple regression analysis revealed that psychic side effect, extrapyramidal side effect, and depression contributed significantly to the total score of KmSWN. These variables accounted for 59.7% of the total variance. Conclusion : The results of the present study suggest that psychic side effect, extrapyramidal side effect and depressive symptom are the clinical characteristics that are significantly associated with the subjective quality of life. An effective management strategy for these variables should be established in developing a treatment program to enhance the quality of life of patients with schizophrenia.

YouTube as a Source of Information and Education on Hysterectomy

Lee Kyong-No,손가현,Park Sung-Ho,Kim Youngmi,박성택 대한의학회 2020 Journal of Korean medical science Vol.35 No.25

Background: Globally, YouTube is one of the most popular websites, and the content is not restricted to entertainment. The purpose of this study was to assess the quality of information in YouTube videos pertaining to hysterectomy. Methods: We explored YouTube using the search terms “hysterectomy” and “remove uterus.” The videos that appeared were sorted using the filter “sort by view count.” Of the initial 100 videos, the top 50 videos for each search term were included for review, as determined by the “relevance” filter based on YouTube's algorithm. After excluding 34 videos for various reasons, 66 were included in the final analysis. Each video rated as “useful” was further analyzed for reliability and completeness of information; a set of pre-determined criteria were modified from a previous study and used to grade the quality of videos. Results: The top 66 videos on hysterectomy had a total of 4,679,118 views. Based on authorship, the videos were categorized as follows: videos uploaded by patients, 37%; academic videos, 35%; videos uploaded by physicians, 13%; commercial videos, 4%; and videos uploaded by non-physicians, 2%. The type of content was also categorized: 50% of the videos recorded personal experiences, 23% recorded surgical techniques, 21% involved explanations of the surgery, and 4% were commercial videos. The majority of the videos made by patients were negatively biased toward hysterectomy surgery (71.72%), while the majority of those made by academics or physicians were surgical educational videos for doctors, not patients. Conclusion: YouTube is currently not an appropriate source for patients to gain information on hysterectomy. Physicians should be aware of the limitations and provide up-to-date and peer-reviewed content on the website.

History-indicated cerclage: Indication, Perioperative outcome, operative complications and new algorithm

( Kyong-no Lee ),( Ji-eun Kim ),( Ga-hyun Son ),( Keun-young Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: The aim of this study is to evaluate indication, perioperative outcome and further evaluation of history-indicated cervical cerclage. 방법: From January 2007 to June 2016, Among who underwent history-indicated cerclage in our hosipital (n=1214), we performed a retrospective observational study of a cohort of patients who delivered their baby in our hosipital (n=418), we evaluated the rates of perioperative and neonatal outcome based on indication for cerclage. Indication for history-indicated cerclage were as follows: 1 or more unexplained spontaneous second-trimester losses or preterm deliveries before 34weeks; a single documented second-trimester loss or preterm delivery characterized by painless cervical dilation suggestive of cervical insufficiency. 결과: There was no intraoperative complication. Peripartum complication include preterm premature rupture of membranes(8%), preterm delivery( 30%), and delivery before 32weeks’ gestational age(11%). And we analyzed neonatal birthweight, 1min Apgars and 5min Apgars and also progesterone treatment or not. 결론: Despite limited level 1 data, History-indicated cerlcage can be recommended for clinicial use in pregnancies with who experienced 1 or more unexplained spontaneous second-trimester losses.

Cervical funneling after Transabdominal cervicoisthmic cerclage, and Repeat cerclage

( Kyong No Lee ),( Eun Ji Whang ),( Keun Young Lee ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

Subcutaneous Toxicity Evaluation of a Combination Vaccine against Hantaan and Puumala Viruses in Rats for 4 Weeks

Lee, Su-Hae,Jung, Eun-Yong,No, Kyong-Ok,Sin, Ji-Soon,Ahn, Chang-Nam,Kim, Dae-Joong,Nam, Sang-Yoon,Kang, Jong-Koo Korean Society of ToxicologyKorea Environmental Mu 2002 Toxicological Research Vol.18 No.2

Hantaan (HTNV) and Puumala (PUUV) viruses cause hemorrhagic fever with renal syndrome in human. In the present study, the repeated dose toxicity of the HTNV-PUUV combination vaccine was evaluated in Sprague-Dawley rats. Animals were injected subcutaneously for 28 days with dosages of 0, 0.017, 0.17 and 1.7 dose/kg body weight per day, respectively. No any significant changes of body weight, food and water consumptions were shown. There were no death and clinical findings during the experimental period. In both male and female rats, there were not significant changes in hematological and serum biochemical analysis, urinalysis, and ophthalmoscopic and histopathological examination. These results indicate that the HTNV-PUUV combination vaccine may have no toxic effects and no observed adverse effect level (NOAEL) may be over 1.7 dose/kg/day at subcutaneous route in rats.

History-indicated cerclage: the association between previous preterm history and cerclage outcome

( Kyong-No Lee ),( Eun-Jee Whang ),( Kylie Hae-Jin Chang ),( Ji-Eun Song ),( Ga-Hyun Son ),( Keun-Young Lee ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.1

Objective Our hospital's policy is to perform history-indicated cerclage (HIC) for pregnant patients with 1 or more second-trimester pregnancy losses. Recently, the American College of Obstetricians and Gynecologists (ACOG) guideline regarding indications for HIC was changed from 3 or more previous second-trimester fetal losses to one or more. In this study, we aimed to evaluate the efficacy of the revised guideline and to investigate the association between previous preterm history and cerclage outcome. Methods We conducted a retrospective observational study of cases of HIC in singleton pregnancies performed at our hospital between January 2007 and June 2016. We compared the perioperative complications and incidences of preterm delivery in patients with one previous second-trimester pregnancy loss against those in patients with ≥2 losses. Results The incidence of preterm delivery (<32 weeks) was significantly lower in patients with one previous second-trimester pregnancy loss than in those with ≥2 losses (15/194 [8%] vs. 28/205 [14%]). In the 1 loss and ≥2 losses groups, the rates of preterm premature rupture of membranes (PPROM) were 7% and 8%, the rates of PPROM at <32 weeks 2.1% and 3.4%, and the ratios of neonatal intensive care unit admission 10% and 17%, respectively. Conclusion Comparison of HIC in one previous second-trimester pregnancy loss group with HIC in the 2 or more previous second-trimester pregnancy loss group found no difference in pregnancy outcome. This finding supports the amended ACOG guideline for HIC indications. Based on our results, we also propose development of a new protocol for HIC-related complications.

Factors associated with spontaneous preterm birth after physical examination-indicated cerclage: An 10-year retrospective cohort study

( Huinsol Lee ),( Kyong-no Lee ),( Byung Hun Kang ),( Young Bok Ko ),( Mina Lee ) 대한산부인과학회 2023 대한산부인과학회 학술대회 Vol.109 No.-

Brown Guinea Pig와 Hairless Mouse를 이용한 광노화 모델에서 LGNC-5의 경구반복투여에 의한 피부주름발생 및 색소침착억제 효과

노경옥(Kyong-Ok No),조호성(Ho-Song Cho),박상기(Sang-Ki Park),이헌식(Heon-Sik Lee),장민열(Min-Youl Chang),이민호(Min-Ho Lee),강상진(Sangjin Kang),조완구(Wan-Goo Cho),박혜지(Hye Ji Park),홍진태(Jin Tae Hong) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4

비타민과 불포화지방산, 그리고 폴리페놀의 복합처방인 LGNC-5 (LG생활건강 기술연구원 개발)가 건강기능식품의 개별인증을 받을 수 있는지의 여부를 확인하기 위해 hairless mice와 brown guinea pig 모델을 이용해 자외선에 의한 주름생성 및 색소침착 억제력 평가를 실시하여 다음과 같은 결괴를 얻었다. 1. Hairless mice를 대상으로 실시한 주름억제실험에서 육안관찰과 피부주형의 영상분석결과, LGNC-5군은 농도의존적인 주름발생 억제효과를 보였으며, 고용량군(x60)인 LGNC-5H군의 경우 10주후 정상군과 유사한 수준의 양호한 피부 상태를 보였다. Hematoxylin & Eosin stain 에서도 LGNC-5H군에서는 UV 대조군에 비해 표피 두께와 과각화가 현저하게 줄어드는 것으로 조사되어 우수한 주름발생억제 효과를 확인하였다. 2. Brown guinea pig을 대상으로 실시한 색소침착억제력 실험에서 육안관찰과 색차계를 이용한 측정결과, LGNC-5H군에서는 설험개시 7일 후부터 UV 대조군에 비해 색소침착이 억제되기 시작해, 설험 종료시까지 색소침착억제효과를 보였다(p<0.05). Fontana-masson silver stain 에서도 LGNC-5H군에서는 UV 대조군에 비해 melanin 침챡량이 현저하게 감소된 것으로 조사되어 LGNC-5H의 색소침착억제효과를 확인하였다. 3. 10주간의 주름억제실험과 4주간의 색소침착 억제실험에 사용한 모든 설험동물에서 사망 혹은 시험물질 투여로 인한 특이한 임상증상이 관찰되지 않았다. 시험물질 투여 기간 중 사료와 음수 소비량 역시 유의한 변화를 관찰할 수 없었으며, 대조군과 실험군 모두 정상적인 체중 증가를 나타내었다. 이상의 실험결과를 종합하면 LGNC-5은 안전하고 경구반복투여 시 UV조사로 인해 hairless mice에서 발생되는 주름과 brown guinea pig에서 생성되는 색소침착을 효과적으로 억제시키는 처방인 것으로 평가되었다. Chronic exposure of UV radiation in sunlight results in a number of biological responses, including erythema, sunburn cell formation, immune suppression, photoaging, and skin cancer. In this study, we investigated the effects of LGNC-5 (LG Nutricosmetics-5, the mixture of vitamins, unsaturated fatty acid and polyphenol) on UV-induced skin damage. Oral administration of LGNC-5 for 10 weeks resulted in inhibition of UVB-induced wrinkle formation in SKH-1 hairless mice skin compared to UV control group as a dose dependent manner. LGNC-5 treatment also inhibited UV radiation-induced skin pigmentation in brown guinea pigs examined by colorimeter and Fontana-masson silver staining. These results mean that LGNC-5 as a dietary supplement could be useful to attenuate solar UVB-induced melanogenesis and premature skin aging.

Subcutaneous Toxicity Evaluation of a Combination Vaccine against Hantaan and Puumala Viruses in Rats for 4 Weeks

Su-Hae Lee,Eun-Yong Jung,Kyong-Ok No,JI Soon Sin,Chang-Nam Ahn 한국독성학회 2002 Toxicological Research Vol.18 No.2

Hantaan (HTNV) and Puumala (PUUV) viruses cause hemorrhagic fever with renal syndrome in human. In the present study, the repeated dose toxicity of the HTNV-PUUV combination vaccine was evaluated in Sprague-Dawley rats. Animals were injected subcutaneously for 28 days with dosages of 0, 0.017, 0.17 and 1.7 dose/kg body weight per day, respectively. No any significant changes of body weight, food and water consumptions were shown. There were no death and clinical findings during the experimental period. In both male and female rats, there were not significant changes in hematological and serum biochemical analysis, urinalysis, and ophthalmoscopic and histopathological examinations. These results indicate that the HTNV-PUUV combination vaccine may have no toxic effects and no observed adverse effect level (NOAEL) may be over 1.7 dose/kg/day at subcutaneous route in rats.

The effect of continuous bupivacaine subfascial wound infusion after cesarean delivery

( Jung Yun Lee ),( Ji Hyun Choi ),( Hyeon Ji Kim ),( Kyong-no Lee ),( Eun Ji Oh ),( Jee Yoon Park ),( Kyung Joon Oh ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: After cesarean delivery, multimodal pain management allows early ambulation and helps rehabilitation. The aim of this study was to determine the effects of continuous bupivacaine subfascial wound infusion added to intravenous (IV) patient-controlled analgesia (PCA). Methods: This retrospective cohort study analyzed total number of 473 patients who underwent cesarean deliveries under spinal anesthesia from August of 2021 to May of 2022. Post-operative analgesic protocol is standardized as follows; 1) all patients were offered postoperative analgesia consisting of IV PCA fentanyl (15mcg/h) and oral ibuprofen (400mg every 8h) as a pain management until post-operative day (POD) 4. 2) additional analgesic was provided if needed. From the January of 2022, continuous subfascial infusion of bupivacaine (2mL/h until POD 2) was added to conventional pain management system for applicants only. Pain scores using numerical rating scale (NRS) and additional use of analgesic were compared between two groups divided by the time of initiation of continuous infusion of bupivacaine. Results: A total number of 473 patients, consisting of 206 patients before the January of 2022 (group 1) and 267 patients after the January of 2022 (group 2), were enrolled. Among the patients in group 2, 19.5% (52/267) of patients refused to use of continuous infusion of bupivacaine. There were no statistically significant differences between two groups, concerning NRS scores at POD 1 to 4 and the rate of additional use of analgesic at POD 1. However, the rate of additional use of analgesic during POD 2 to 4 was significantly lower in group 2, compared to group 1. Conclusion: Continuous subfascial infusion of bupivacaine can help reduce additional use of pain relief after cesarean delivery.