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( Dawn Chung ),( Kiyoon Eom ),( Sunyoung Park ),( Hyemi Cho ),( Kwang Hwa Park ),( Hyeyoung Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: MicroRNAs (miRNAs) are small noncoding RNAs of about 22 nucleotides and have negative regulatory action of gene expression at post-transcriptional period through mRNA degradation and/or translation repression. These molecules have been studied as potential biomarkers in many important biological processes, including cell growth, apoptosis, viral infection and cancer development. Several oncogenic miRNAs have been reported to be associated with cervical cancer tumorigenesis as well. 방법: Among many oncogenic miRNAs, miR-9, miR-21, miR-155, and miR-944 are known to promote cell growth, migration and invasion in cervical cancer. However, the relationship between miRNAs and HR-HPV infection has not been fully understood, and few studies have been generated using clinical samples. The aim of this study was to investigate the expression levels of miR-9, miR-21, miR-155, and miR-944 in formalin-fixed paraffin- embedded (FFPE) samples and to find out relationship between miRNA expression and HR-HPV infection using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In this study, HR-HPV infection was determined by RT-qPCR targeting E6/E7, oncogenes of HPV. 결과: In brief, the results from this study showed that the expression levels of miR-9, miR-21, miR-155, and miR-944 in FFPE cervical cancer tissues were higher than in normal tissues. Among four miRNAs, miR-21 expression levels in both HR-HPV E6/E7-positive cancer tissues and -negative cancer tissues were significantly up-regulated. In other words, miR-21 expression level was up-regulated regardless of HR-HPV E6/E7 expression levels. In conclusion, this study seems to suggest that four miRNAs were up-regulated in cervical cancer tissues compared to normal tissues. 결론: Therefore, miR-9, miR-21, miR-155 and miR-944 seem to can be useful biomarkers for the diagnosis of cervical cancer.
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