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Metalens for improving optical coherence tomography
Guo Songming,Feng Weibin,Long Yong,Liu Zhihao,Fu Xiao,Liang Haowen,Li Juntao 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.1
Optical coherence tomography is one of the most attractive new tomographic techniques, especially in the detection and imaging of biological tissues. For the detection and imaging of human corneas, the current ultra-high-resolution optical coherence tomography technology faces the challenge that the depth of focus is too short to scan the entire human cornea in a single amplitude scan. Here, we propose and design a silicon metalens to replace the objective lens in the sample arm of the optical coherence tomography system. In our simulation, a uniform focused beam with a depth of focus of 886 μm, an axial resolution of 3.1 μm and a lateral resolution of 2.2 μm can be generated by the metalens, which is under the excitation of broadband Gaussian light with wavelength coverage from 800 to 900 nm. This metalens fully satisfies the depth of focus and resolution requirements of the ultra-high-resolution optical coherence tomography system for human corneas, hence expands the application of optical coherence tomography in medical science for the benefit of mankind.
Propamidine decreas mitochondrial complex 3 activity of Botrytis cinerea
( Fangli Wu ),( Weibo Jin ),( Juntao Feng ),( Anliang Chen ),( Zhiqing Ma ),( Xing Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.9
Propamidine, an aromatic diamidine compound, is widely used as an antimicrobial agent. To uncover its mechanism on pathogenetic fungi, Botrytis cinerea as an object was used to investigate effects of propamidine in this paper. The transmission electron microscope results showed that the mitochondrial membranes were collapsed after propamidine treatment, followed that mitochondria were disrupted. Inhibition of whole-cell and mitochondrial respiration by propamidine suggested that Propamidine is most likely an inhibitor of electron transport within Botrytis cinerea mitochondria. Furthermore, the mitochondrial complex 3 activity were inhibited by propamidine. [BMB reports 2010; 43(9): 614-621]