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Propamidine decreas mitochondrial complex 3 activity of Botrytis cinerea
( Fangli Wu ),( Weibo Jin ),( Juntao Feng ),( Anliang Chen ),( Zhiqing Ma ),( Xing Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.9
Propamidine, an aromatic diamidine compound, is widely used as an antimicrobial agent. To uncover its mechanism on pathogenetic fungi, Botrytis cinerea as an object was used to investigate effects of propamidine in this paper. The transmission electron microscope results showed that the mitochondrial membranes were collapsed after propamidine treatment, followed that mitochondria were disrupted. Inhibition of whole-cell and mitochondrial respiration by propamidine suggested that Propamidine is most likely an inhibitor of electron transport within Botrytis cinerea mitochondria. Furthermore, the mitochondrial complex 3 activity were inhibited by propamidine. [BMB reports 2010; 43(9): 614-621]
Yanqiu Chen,Jin Zhang,Peishi Yu,Jian Wu,Weibo Wang,Junhua Zhao 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.4
The stress and strain concentration in some component has been a signifi cant topic for structural safety assessment. However, the evaluation of the stress and strain concentration based on the widely existing solutions for linear elastic material under static loading would lead to remarkable errors when the material undergoes the dynamic loading, since the coupling eff ect induced by the nonlinearity of the stress–strain relationship and the strain-rate strengthening could be of signifi cant infl uence. Here we analyzed the strain-rate dependent concentration of stress and strain for a visco-plastic plate with an elliptic hole subjected to dynamic loading. The three-dimensional stress and strain are calculated by fi nite element analyses based on a rate-dependent Johnson–Cook model in which the material constants are set according to a typical visco-plastic standard 45 carbon steel. Our results show that both the plastic stress and strain concentration factors signifi cantly depend on not only the strain but also the strain rate. With the increment of the remote strain rate, the stress concentration monotonically increases, while the strain concentration shows decreasing tendency.