Scaling of binding affinities and cooperativities of surfactants on carbon nanotubes

Park, Minsuk,Park, Junmo,Lee, Jiyun,Ju, Sang-Yong Elsevier 2018 Carbon Vol.139 No.-

<P><B>Abstract</B></P> <P>High-end applications of single-walled carbon nanotube (SWNT) require detailed understanding of their binding affinity (<I>K</I> <SUB>d</SUB>) with surfactants. Here, we quantitatively determined the comprehensive <I>K</I> <SUB>d</SUB> and aggregation number (γ) of nine nonionic and anionic surfactants according to SWNT chirality. Photoluminescence (PL)-based titration using flavin mononucleotide (FMN)-SWNT complexes showing the largest redshifted optical transition enabled quantitative comparison of the surfactants and displayed distinct first and second regimes which correspond to partial and full replacements of FMN, respectively. Especially, the second transition exhibited sigmoidal PL change whose middle point denoted by the inverse of <I>K</I> <SUB>d</SUB> slightly differs from critical micelle concentration of surfactant alone, depending on its functional groups. Moreover, nonionic surfactants displayed larger <I>K</I> <SUB>d</SUB> and lower γ values than the anionic did. Specifically, <I>K</I> <SUB>d</SUB> values between Pluronic F108 and sodium dodecyl sulfonate differ by four orders of magnitude. Such differences were rationalized in terms of the occupied volume of the micelle based on the hydrodynamic volume and γ. During the replacement, <I>K</I> <SUB>d</SUB> and γ were affected by the degree of surfactant rearrangement induced by aging process, leading to more stable complex. Scaling the interactions between surfactant and SWNT provides useful guidelines to design novel SWNT sorting method using more than two surfactants.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A Pilot Study about Possible Gluten Sensitivity in Korean Urticaria Patients

( Jiyun Park ),( Daewook Lee ),( Seung Hwi Kwon ),( Jin Young Song ),( Yoo Sang Baek ),( Jiehyun Jeon ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.5

Brønsted Acid-Promoted C–H Bond Cleavage via Electron Transfer from Toluene Derivatives to a Protonated Nonheme Iron(IV)-Oxo Complex with No Kinetic Isotope Effect

Park, Jiyun,Lee, Yong-Min,Nam, Wonwoo,Fukuzumi, Shunichi American Chemical Society 2013 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.135 No.13

<P>The reactivity of a nonheme iron(IV)-oxo complex, [(N4Py)Fe<SUP>IV</SUP>(O)]<SUP>2+</SUP> (N4Py = <I>N</I>,<I>N</I>-bis(2-pyridylmethyl)-<I>N</I>-bis(2-pyridyl)methylamine), was markedly enhanced by perchloric acid (70% HClO<SUB>4</SUB>) in the oxidation of toluene derivatives. Toluene, which has a high one-electron oxidation potential (<I>E</I><SUB>ox</SUB> = 2.20 V vs SCE), was oxidized by [(N4Py)Fe<SUP>IV</SUP>(O)]<SUP>2+</SUP> in the presence of HClO<SUB>4</SUB> in acetonitrile (MeCN) to yield a stoichiometric amount of benzyl alcohol, in which [(N4Py)Fe<SUP>IV</SUP>(O)]<SUP>2+</SUP> was reduced to [(N4Py)Fe<SUP>III</SUP>(OH<SUB>2</SUB>)]<SUP>3+</SUP>. The second-order rate constant (<I>k</I><SUB>obs</SUB>) of the oxidation of toluene derivatives by [(N4Py)Fe<SUP>IV</SUP>(O)]<SUP>2+</SUP> increased with increasing concentration of HClO<SUB>4</SUB>, showing the first-order dependence on [HClO<SUB>4</SUB>]. A significant kinetic isotope effect (KIE) was observed when mesitylene was replaced by mesitylene-<I>d</I><SUB>12</SUB> in the oxidation with [(N4Py)Fe<SUP>IV</SUP>(O)]<SUP>2+</SUP> in the absence of HClO<SUB>4</SUB> in MeCN at 298 K. The KIE value drastically decreased from KIE = 31 in the absence of HClO<SUB>4</SUB> to KIE = 1.0 with increasing concentration of HClO<SUB>4</SUB>, accompanied by the large acceleration of the oxidation rate. The absence of KIE suggests that electron transfer from a toluene derivative to the protonated iron(IV)-oxo complex ([(N4Py)Fe<SUP>IV</SUP>(OH)]<SUP>3+</SUP>) is the rate-determining step in the acid-promoted oxidation reaction. The detailed kinetic analysis in light of the Marcus theory of electron transfer has revealed that the acid-promoted C–H bond cleavage proceeds via the rate-determining electron transfer from toluene derivatives to [(N4Py)Fe<SUP>IV</SUP>(OH)]<SUP>3+</SUP> through formation of strong precursor complexes between toluene derivatives and [(N4Py)Fe<SUP>IV</SUP>(OH)]<SUP>3+</SUP>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2013/jacsat.2013.135.issue-13/ja311662w/production/images/medium/ja-2012-11662w_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja311662w'>ACS Electronic Supporting Info</A></P>

Development and Effectiveness of a Basic Epidemiological Investigation Simulation Program of Emerging Respiratory Infectious Diseases for Nursing Students: Application of Standardized Patients

Jiyun Park,Gye Jeong Yeom 한국지역사회간호학회 2023 지역사회간호학회지 Vol.34 No.4

Purpose: This study aimed to develop a simulation-based education program of emerging respiratory infectious diseases using standardized patients for nursing students, and to test the effects on basic epidemiological investigation performed while wearing Level D Personal Protective Equipment (PPE). Methods: A total of 64 senior nursing students were recruited and assigned to either the experimental group (n=33) or a control group (n=31) in May 2022. This program was developed based on the analysis, design, development, implementation, and evaluation model. The analysis phase consisted of a literature review and target group survey. In addition, learning objectives and a structure were designed, and a scenario was developed with expert consulting. In the implementation phase, the program was conducted the course of 3 hours. The evaluation phase involved verification of the effects on clinical performance, self-efficacy, and anxiety related to basic epidemiological investigation, as well as an assessment of satisfaction with the program. Results: There were significant differences between the experimental and control groups in clinical performance (Z=-2.15, p=.010) and anxiety related to basic epidemiological investigation (Z=-4.02, p<.001). However, there was no significant difference in self-efficacy related to basic epidemiological investigation. Conclusion: The results indicate that this simulation-based education program was effective in improving clinical performance and reducing anxiety related to basic epidemiological investigation of nursing students. In addition, this program is expected to be widely used as an epidemiological investigation education for the initial prevention of infectious diseases.

Colorimetric detection of microRNA miR-21 based on nanoplasmonic core–satellite assembly

Park, Jiyun,Yeo, Jong-Souk The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.11

<P>In order to detect microRNAs (miRNAs), we developed a colorimetric sensing method on the basis of the plasmonic coupling effect. Gold nanoplasmonic particles (GNPs) are assembled in a core–satellite configuration in the presence of target miRNA, inducing remarkable changes in the scattering color and spectra at the picomolar level with selectivity.</P> <P>Graphic Abstract</P><P>We have developed a novel method to detect microRNAs with color change based on the nanoplasmonic coupling effect from core–satellite assembly. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc48154a'> </P>

Efficient Epoxidation of Styrene Derivatives by a Nonheme Iron(IV)-Oxo Complex via Proton-Coupled Electron Transfer with Triflic Acid

Park, Jiyun,Lee, Yong-Min,Ohkubo, Kei,Nam, Wonwoo,Fukuzumi, Shunichi American Chemical Society 2015 Inorganic Chemistry Vol.54 No.12

<P>Styrene derivatives are not oxidized by [(N4Py)Fe-IV(O)](2+) (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) in acetonitrile at 298 K, whereas epoxidation of styrene derivatives by the iron(IV)-oxo complex occurs efficiently in the presence of triflic acid (HOTf) via proton-coupled electron transfer (PCET) from styrene derivatives to the diprotonated species of [(N4Py)Fe-IV(O)](2+) with HOTf. Logarithms of the firstorder rate constants of HOTf-promoted expoxidation of styrene derivatives with [(N4Py)Fe-IV(O)](2+) and PCET from electron donors to [(N4Py)Fe-IV(O)](2+) in the precursor complexes exhibit a remarkably unified correlation with the driving force of PCET in light of the Marcus theory of electron transfer when the differences in the formation constants of precursor complexes are taken into account. The same PCET driving force dependence is obtained for the first-order rate constants of HOTf-promoted oxygen atom transfer from thioanisols to [(N4Py)Fe-IV(O)](2+) and HOTf-promoted hydrogen atom transfer from toluene derivatives to [(N4Py)Fe-IV(O)](2+) in the precursor complexes. Thus, HOTf-promoted epoxidation of styrene derivatives by [(N4Py)Fe-IV(O)](2+) proceeds via the rate-determining electron transfer from styrene derivatives to the diprotonated species of [(N4Py)Fe-IV(O)](2+), as shown in the reactions of HOTf-promoted oxygen atom transfer from thioanisols to [(N4Py)Fe-IV(O)](2+) and HOTf-promoted hydrogen atom transfer from toluene derivatives to [(N4Py)Fe-IV(O)](2+).</P>

The physical and emotional health of South Korean mothers of preterm infants in the early postpartum period: a descriptive correlational study

Jiyun Park,Kyung-Sook Bang 한국아동간호학회 2022 Child Health Nursing Research Vol.28 No.2

Purpose: This study investigated the physical and emotional health of South Korean mothers of preterm infants in the early postpartum period. Methods: In this descriptive correlational study, the participants included 91 mothers of preterm infants who were admitted to the neonatal intensive care unit of a tertiary hospital in South Korea. Physical health status was measured using a self-reported questionnaire, postpartum depression using the Edinburgh Postnatal Depression Scale, anxiety using the State-Trait Anxiety Inventory, and guilt using a 4-item scale. Results: Fatigue had the highest score among mothers' physical health problems, followed by shoulder pain, nipple pain, neck pain. The average postpartum depression score was 11.02 points, and 44% of women had postpartum depression with a score of 12 or above. Postpartum depression significantly was correlated with physical health (r=.35, p=.001), anxiety (r=.84, p<.001), and guilt (r=.75, p<.001) and was significantly higher for women with multiple births, and preterm infants who required ventilator and antibiotic treatment. Anxiety also showed a significant difference according to preterm infants’ condition. Conclusion: The significant correlations between postpartum depression and physical health, anxiety, and guilt indicate a need for nursing interventions that provide integrated management of mothers’ physical and emotional health.

Metal Ion Effect on the Switch of Mechanism from Direct Oxygen Transfer to Metal Ion-Coupled Electron Transfer in the Sulfoxidation of Thioanisoles by a Non-Heme Iron(IV)−Oxo Complex

Park, Jiyun,Morimoto, Yuma,Lee, Yong-Min,Nam, Wonwoo,Fukuzumi, Shunichi American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.14

<P>The mechanism of sulfoxidation of thioaniosoles by a non-heme iron(IV)−oxo complex is switched from direct oxygen transfer to metal ion-coupled electron transfer by the presence of Sc<SUP>3+</SUP>. The switch in the sulfoxidation mechanism is dependent on the one-electron oxidation potentials of thioanisoles. The rate of sulfoxidation is accelerated as much as 10<SUP>2</SUP>-fold by the addition of Sc<SUP>3+</SUP>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-14/ja200901n/production/images/medium/ja-2011-00901n_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja200901n'>ACS Electronic Supporting Info</A></P>

Overexpression of Neuron-Specific Enolase as a Prognostic Factor in Patients with Gastric Cancer

Park, Taejin,Lee, Young-Joon,Jeong, Sang-Ho,Choi, Sang-Kyung,Jung, Eun-Jung,Ju, Young-tae,Jeong, Chi-Young,Park, Miyeong,Hah, Young-Sool,Yoo, Jiyun,Ha, Woo-Song,Hong, Soon-Chan,Ko, Gyung Hyuck The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.3

Purpose: Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC). Materials and Methods: To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens. Cytoplasmic NSE expression was scored from 0 to 4, reflecting the percentage of NSE-positive cells. Results: In terms of histology as per the World Health Organization criteria (P=0.34), there were no differences between the NSE overexpression (NSE-OE) and NSE underexpression (NSE-UE) groups. The NSE-OE group showed a significantly lower rate of advanced GC (P<0.01), lymph node metastasis (P=0.01), advanced stage group (P<0.01), cancer-related death (P<0.01), and cancer recurrence (P<0.01). Additionally, a Kaplan-Meier survival analysis revealed that the NSE-OE group had longer cumulative survival times than the NSE-UE group (log-rank test, P<0.01). However, there were no significant differences in the serum levels of NSE expression in patients with GC and healthy volunteers (P=0.28). Conclusions: Patients with NSE overexpressing GC tissues showed better prognostic results, implying that NSE could be a candidate biomarker of GC.

Scandium Ion-Enhanced Oxidative Dimerization and <i>N</i>-Demethylation of <i>N</i>,<i>N</i>-Dimethylanilines by a Non-Heme Iron(IV)-Oxo Complex

Park, Jiyun,Morimoto, Yuma,Lee, Yong-Min,You, Youngmin,Nam, Wonwoo,Fukuzumi, Shunichi American Chemical Society 2011 Inorganic Chemistry Vol.50 No.22

<P>Oxidative dimerization of <I>N</I>,<I>N</I>-dimethylaniline (DMA) occurs with a nonheme iron(IV)-oxo complex, [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP> (N4Py = <I>N</I>,<I>N</I>-bis(2-pyridylmethyl)-<I>N</I>-bis(2-pyridyl)methylamine), to yield the corresponding dimer, tetramethylbenzidine (TMB), in acetonitrile. The rate of the oxidative dimerization of DMA by [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP> is markedly enhanced by the presence of scandium triflate, Sc(OTf)<SUB>3</SUB> (OTf = CF<SUB>3</SUB>SO<SUB>3</SUB><SUP>–</SUP>), when TMB is further oxidized to the radical cation (TMB<SUP>•+</SUP>). In contrast, we have observed the oxidative N-demethylation with <I>para</I>-substituted DMA substrates, since the position of the C–C bond formation to yield the dimer is blocked. The rate of the oxidative N-demethylation of <I>para</I>-substituted DMA by [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP> is also markedly enhanced by the presence of Sc(OTf)<SUB>3</SUB>. In the case of <I>para</I>-substituted DMA derivatives with electron-donating substituents, radical cations of DMA derivatives are initially formed by Sc<SUP>3+</SUP> ion-coupled electron transfer from DMA derivatives to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP>, giving demethylated products. Binding of Sc<SUP>3+</SUP> to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP> enhances the Sc<SUP>3+</SUP> ion-coupled electron transfer from DMA derivatives to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP>, whereas binding of Sc<SUP>3+</SUP> to DMA derivatives retards the electron-transfer reaction. The complicated kinetics of the Sc<SUP>3+</SUP> ion-coupled electron transfer from DMA derivatives to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP> are analyzed by competition between binding of Sc<SUP>3+</SUP> to DMA derivatives and to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP>. The binding constants of Sc<SUP>3+</SUP> to DMA derivatives increase with the increase of the electron-donating ability of the <I>para</I>-substituent. The rate constants of Sc<SUP>3+</SUP> ion-coupled electron transfer from DMA derivatives to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP>, which are estimated from the binding constants of Sc<SUP>3+</SUP> to DMA derivatives, agree well with those predicted from the driving force dependence of the rate constants of Sc<SUP>3+</SUP> ion-coupled electron transfer from one-electron reductants to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP>. Thus, oxidative dimerization of DMA and N-demethylation of <I>para-</I>substituted DMA derivatives proceed via Sc<SUP>3+</SUP> ion-coupled electron transfer from DMA derivatives to [Fe<SUP>IV</SUP>(O)(N4Py)]<SUP>2+</SUP>.</P><P>Competition between binding of Sc<SUP>3+</SUP> ion to <I>N</I>,<I>N</I>-dimethylaniline (DMA) derivatives and a non-heme iron(IV)-oxo complex results in overall enhancement of electron transfer from DMA derivatives to a non-heme iron(IV)-oxo complex, leading to oxidative dimerization of DMA and N-demethylation of para-substituted DMA.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2011/inocaj.2011.50.issue-22/ic201545a/production/images/medium/ic-2011-01545a_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic201545a'>ACS Electronic Supporting Info</A></P>