Effect of Oral Administration of Acetaminophen and Topical Application of EMLA on Pain during Transrectal Ultrasound-Guided Prostate Biopsy

Kim, Seol,Yoon, Byung Il,Kim, Su Jin,Cho, Hyuk Jin,Kim, Hyo Sin,Hong, Sung Hoo,Lee, Ji Youl,Hwang, Tae-Kon,Kim, Sae Woong The Korean Urological Association 2011 Korean Journal of Urology Vol.52 No.7

<P><B>Purpose</B></P><P>Transrectal ultrasound-guided prostate biopsy is the procedure of choice for diagnosing prostate cancer. We compared with pain-relieving effect of acetaminophen, a known drug for enhancing the pain-relieving effect of tramadol, and eutectic mixture of local anesthetics (EMLA), a local anesthetic agent, with that of the conventional periprostatic nerve block method.</P><P><B>Materials and Methods</B></P><P>This was a prospective, randomized, single-blinded study. A total of 430 patients were randomly assigned to three groups. Group 1 received a periprostatic nerve block with 1% lidocaine, group 2 received acetaminophen 650 mg, and group 3 received EMLA cream for pain control. All patients were given 50 mg of tramadol intravenously 30 minutes before the procedure. At 3 hours after completion of the procedure, the patients were asked to grade their pain on a horizontal visual analogue scale (VAS). The patients were also asked whether they were willing to undergo future biopsy if required.</P><P><B>Results</B></P><P>There were no significant differences between the three groups in terms of age, prostate-specific antigen, prostate size, or numbers of biopsy cores. The pain scores for groups 2 and group 3, which were 3.47±1.92 and 3.50±1.36, respectively, were similar and were significantly lower than that of group 1, which was 5.24±2.07.</P><P><B>Conclusions</B></P><P>Acetaminophen and EMLA cream with intravenous injection of tramadol are safe, easy, and effective methods of controlling pain during the procedure. These methods were more effective for pain relief than was the conventional periprostatic nerve block method.</P>

뜬 마이크로 디바이스를 이용한 dragline spider silk의 열전도율 측정과 ALD 증착에 의한 열전도율 감소

최지웅(Ji Woong Choi),한준규(Jun Kyu Han),김덕종(Duk Jong Kim),이승모(Seung Mo Lee),소혜미(Hye Mi So),설재훈(Jae Hun Seol) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.열공학 No.-

Fabrication of an ionic/electronic nanocomposite for a high flux oxygen ion transport membrane

Jong Seol Yoon,Young Chul Cha,Ji-Woong Moon,황해진 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.4

Ce0.9Gd0.1O2−δ (GDC)/Ba0.5Sr0.5Co0.8Fe0.2O3−δ (BSCF) nanocomposites were fabricated by a conventional power processing technique from a commercially available GDC and a BSCF powder prepared in-house. The BSCF was synthesized via the glycine-nitrate process (GNP). XRD analysis indicated that the GDC was found to be compatible with the BSCF at a sintering temperature of 1150 oC. Dense GDC/BSCF nanocomposites having a relative density above 95% could be obtained when a green compact of BSCF and GDC powder mixture was sintered at 1150 oC for 5 h. GDC particles were found to be homogeneously dispersed in the BSCF matrix and some smaller GDC particles less than a few hundred nm in size were incorporated inside the large BSCF grains. The grain size of the BSCF was decreased by an addition of the GDC, suggesting the GDC can hinder the grain growth of the BSCF. Ce0.9Gd0.1O2−δ (GDC)/Ba0.5Sr0.5Co0.8Fe0.2O3−δ (BSCF) nanocomposites were fabricated by a conventional power processing technique from a commercially available GDC and a BSCF powder prepared in-house. The BSCF was synthesized via the glycine-nitrate process (GNP). XRD analysis indicated that the GDC was found to be compatible with the BSCF at a sintering temperature of 1150 oC. Dense GDC/BSCF nanocomposites having a relative density above 95% could be obtained when a green compact of BSCF and GDC powder mixture was sintered at 1150 oC for 5 h. GDC particles were found to be homogeneously dispersed in the BSCF matrix and some smaller GDC particles less than a few hundred nm in size were incorporated inside the large BSCF grains. The grain size of the BSCF was decreased by an addition of the GDC, suggesting the GDC can hinder the grain growth of the BSCF.

드랙라인 거미줄의 (spider dragline silk) 열전도율 측정

최지웅(Ji Woong Choi),김덕종(Duk Jong Kim),이승모(Seung Mo Lee),소혜미(Hye Mi So),설재훈(Jae Hun Seol) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-3

뜬 마이크로 디바이스 (suspended microdevice) 를 이용한 드랙라인 거미줄의 (spider dragline silk) 열전도율 측정

최지웅(Ji Woong Choi),김덕종(Duk Jong Kim),이승모(Seung Mo Lee),소혜미(Hye Mi So),설재훈(Jae Hun Seol) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11

Consumptive coating layer synthesis by a sol-gel technique on a stainless steel substrate for an IT-SOFC separator

Eun A Lee,Jong Seol Yoon,Ji-Woong Moon,Nam-ung Cho,황해진 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.5

The manufacturing costs of solid oxide fuel cells (SOFCs) could feasibly be reduced by using ferritic stainless steel (SUS) interconnectors. However, the stainless steel interconnector suffers from poor oxidation resistance at the IT-SOFC operating temperature. In order to solve this problem, we coated LaCrO3 or strontium-doped LaCrO3 on SUS444 as an oxidation protective layer by a sol-gel technique. Precursor solutions with different metal ion concentrations (0.1, 0.3, and 0.5 mol/l) were prepared from metal nitrates, ethylene glycol, and nitric acid. Dense coating layers with a thickness of 0.8 to 2 μm could be obtained upon heat-treatment of gel films at 700 oC in an air atmosphere. It was found that the thickness and microstructure of the coating layers depended on the concentration of the precursor solution. The oxidation behavior of the LaCrO3 or strontium-doped LaCrO3-coated SUS444 was compared with that of bare SUS444. Area specific resistances (ASR) of the SUS444 substrates were measured as a function of temperature. The ASR monotonically decreased with an increase in the concentration of the precursor solution. The manufacturing costs of solid oxide fuel cells (SOFCs) could feasibly be reduced by using ferritic stainless steel (SUS) interconnectors. However, the stainless steel interconnector suffers from poor oxidation resistance at the IT-SOFC operating temperature. In order to solve this problem, we coated LaCrO3 or strontium-doped LaCrO3 on SUS444 as an oxidation protective layer by a sol-gel technique. Precursor solutions with different metal ion concentrations (0.1, 0.3, and 0.5 mol/l) were prepared from metal nitrates, ethylene glycol, and nitric acid. Dense coating layers with a thickness of 0.8 to 2 μm could be obtained upon heat-treatment of gel films at 700 oC in an air atmosphere. It was found that the thickness and microstructure of the coating layers depended on the concentration of the precursor solution. The oxidation behavior of the LaCrO3 or strontium-doped LaCrO3-coated SUS444 was compared with that of bare SUS444. Area specific resistances (ASR) of the SUS444 substrates were measured as a function of temperature. The ASR monotonically decreased with an increase in the concentration of the precursor solution.

Positive feedback regulation of Akt‐FMRP pathway protects neurons from cell death

Jeon, Se Jin,Han, Seol‐,Heui,Yang, Sung‐,Il,Choi, Ji woong,Kwon, Kyoung Ja,Park, Seung Hwa,Kim, Hahn Young,Cheong, Jae Hoon,Ryu, Jong Hoon,Ko, Kwang Ho,Wells, David G,Shin, Chan Young Blackwell Publishing Ltd 2012 Journal of Neurochemistry Vol.123 No.2

<P><I>J. Neurochem.</I> (2012) <B>123</B>, 226–238.</P><P><B>Abstract</B></P><P>Fragile X syndrome (FXS), the most common single genetic cause of mental retardation and autistic spectrum disease, occurs when <I>FMR1</I> gene is mutated. <I>FMR1</I> encodes fragile X mental retardation protein (FMRP) which regulates translation of mRNAs playing important roles in the development of neurons as well as formation and maintenance of synapses. To examine whether FMRP regulates cell viability, we induced apoptosis in rat primary cortical neurons with glutamate <I>in vitro</I> and with middle cerebral artery occlusion (MCAO) in striatal neurons <I>in vivo</I>. Both conditions elicited a rapid, but transient FMRP expression in neurons. This up‐regulated FMRP expression was abolished by pre‐treatment with PI3K and Protein Kinase B (Akt) inhibitors: LY294002, Akt inhibitor IV, and VIII. Reduced FMRP expression <I>in vitro</I> or <I>in vivo</I> using small hairpin <I>Fmr1</I> virus exacerbated cell death by glutamate or MCAO, presumably <I>via</I> hypophosphorylation of Akt and reduced expression of B‐cell lymphoma‐extra large (Bcl‐xL). However, over‐expression of FMRP using enhanced green fluorescent protein (eGFP)‐FMRP constructs alleviated cell death, increased Akt activity, and enhanced Bcl‐xL production. The pro‐survival role of Akt‐dependent up‐regulation of FMRP in glutamate‐stimulated cultured neuron as well as in ischemic brain may have a clinical importance in FXS as well as in neurodegenerative disorders and traumatic brain injury.</P>

Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors

Lee, Boram,Lee, Ji Won,Shim, Joon Ho,Joung, Je-Gun,Yun, Jae Won,Bae, Joon Seol,Shin, Hyun-Tae,Sung, Ki Woong,Park, Woong-Yang Neoplasia Press 2018 Translational oncology Vol.11 No.6

<P><I>PURPOSE:</I> Relapsed/refractory pediatric cancers show poor prognosis; however, their genomic patterns remain unknown. To investigate the genetic mechanisms of tumor relapse and therapy resistance, we characterized genomic alterations in diagnostic and relapsed lesions in patients with relapsed/refractory pediatric solid tumors using targeted deep sequencing. <I>PATIENTS AND METHODS:</I> A targeted sequencing panel covering the exons of 381 cancer genes was used to characterize 19 paired diagnostic and relapsed samples from patients with relapsed/refractory pediatric solid tumors. <I>RESULTS:</I> The mean coverage for all samples was 930.6× (SD = 213.8). Among the 381 genes, 173 single nucleotide variations (SNVs)/insertion-deletions (InDels), 100 copy number alterations, and 1 structural variation were detected. A total of 72.6% of SNVs in primary tumors were also found in recurrent lesions, and 27.2% of SNVs in recurrent tumors had newly occurred. Among SNVs/InDels detected only in recurrent lesions, 71% had a low variant allele fraction (<10%). Patients were classified into three categories based on the mutation patterns after cancer treatment. A significant association between the major mutation patterns and clinical outcome was observed. Patients whose relapsed tumor had fewer mutations than the diagnostic sample tended to be older, had longer progression-free survival, and achieved complete remission after relapse. Contrastingly, patients whose genetic profile only had concordant mutations without any change had the worst outcome. <I>CONCLUSIONS:</I> We characterized genomic changes in recurrent pediatric solid tumors. These findings could help to understand the biology of relapsed childhood cancer and to develop personalized treatment based on their genetic profile.</P>

NFI-C 결손 생쥐의 유지와 특성

Kawng Hee Cho,Dong-seol Lee,Seong-Ho Yoon,Hyun Sook Bae,Heung-Joong Kim,Ji-Woong Kim,JOO-CHEOL PARK 대한구강해부학회 2007 대한구강해부학회지 Vol.31 No.1

The phylogenetically conserved nuclear factorI (NFI) gene family encodes site- specific transcription factors essential for the development of a number of organ systems, 까lere are four Nfi genes in mammals (j\뼈, Nfib, Nfic, and Njix) and singJe Nfi genes in Drosophila melanogaster, Caenorhabditis elegans, Anophelesspp‘, and other simple animals, NF1-C nul1 mice demonstrated aberrant odontoblast differentiation, abnormal dentin formation, and thus molar lacking roots while other tissueslorgans in the body, including ameloblasts appear to be unaffected and nOlmal, However, little is known about the mechanism of NF1 -C function in odontoblast differentiation and dentin formation, 1n 뻐s study, growth, fertility and morphological characteristics of Nfic-disruption were observed in order to maintain and characterize the NF1 -C nul\ mice, The results were as follows: 1. Fourteen heterozygotes corsses prodllced 215 Fl progeny distribllted: 134 wild type, 78 Nji-c.I . , and 4 Nfi-c.I . , The single PCR distinguishes both genotype and sex, Primer A and B amplified 545 bp of the Njic gene with neo-cassette, whereas primerò A and C amplified 3많 bp of the original Nfic gene 2, Gross observations of the mOllth and jaw of Nji-c-l- mice revealed virtually no mandibular incisors overgrown, thin maxillary mClsors 3. There were no growth retardation and increased moπ머ity of Nfi-c.l . mice 4, 1n morphological observation, abnormal odontoblasts of the NF1 -C nul1 mouse were round in shape, lost their p뼈rity, organized as a sheet of cel1s, and trapped in osteodentin-like mineralized tissue, These results suggested that this animal model provides invaluable information on lInderstanding the molecular processes responsible for odontoblast differentiation and dentin formation.

sI 천연 메탄하이드레이드의 존재

연순화(Yeon, Sun-Hwa),설지웅(Seol, Ji-Woong),이흔(Lee, Huen) 한국신재생에너지학회 2006 한국신재생에너지학회 학술대회논문집 Vol.2006 No.06

We report here that under strong attacksof external CH₄ guest molecules the sII and sH methane hydrates are structurally transformed to the crystalline me framework of sI, leading to favorable change of the lattice dimension of the host-guest networks. The High Power Decoupling ¹³C NMR and Raman spectroscopies were used to identify structure transitions of the mixed CH₄+C₂H₆ hydrates (sIIl) and hydrocarbons (methylcyclohexane, isopentane) + CH₄ hydrates (sH). The resulting spectra indicate that most of the synthesized sII and sH hydrates were transformed to methane hydrate of sl under 110 bar and particularly the coexistence of sl with sII or sH appear according to the surrounding methane-rich gas conditions. The present findings might be expected to Provide rational evidences regarding the preponderant occurrence of naturally-occurring sI methane hydrates in marine sediments.