http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Jee Hung,Park, Hyung Soon,Heo, Su Jin,Kim, Sang Kyum,Han, Jung Woo,Shin, Kyoo-Ho,Kim, Seung Hyun,Hur, Hyuk,Kim, Kyung Sik,Choi, Young Deuk,Kim, Sunghoon,Lee, Young Han,Suh, Jin-Suck,Ahn, Joong-Ba S. Karger AG 2019 Oncology Vol.96 No.2
<P><B><I>Background:</I></B> We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). <B><I>Methods:</I></B> Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyzed. <B><I>Results:</I></B> Forty-six and 45 patients received pazopanib and gemcitabine/docetaxel, respectively. The median progression-free survival for the group treated with pazopanib was 4.5 months compared with 3.0 months for the gemcitabine/docetaxel group (<I>p</I> = 0.593). The median overall survival for the group treated with pazopanib was 12.6 months compared with 14.2 months for the gemcitabine/docetaxel group (<I>p</I> = 0.362). The overall response rates (ORRs) were 6.5 and 26.7% in the pazopanib and gemcitabine/docetaxel groups, respectively. The following parameters had ORRs favoring gemcitabine/docetaxel: age ≥50 years (31.6 vs. 2.9%, <I>p</I> = 0.006), histologic grade 1–2 (40.9 vs. 0%, <I>p</I> = 0.001), and poor first-line treatment response (23.3 vs. 3.0%, <I>p</I> = 0.022). Gemcitabine/docetaxel was associated with better ORRs for the following histologic subtypes: leiomyosarcoma (<I>p</I> = 0.624), malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (<I>p</I> = 0.055), and angiosarcoma (<I>p</I> = 0.182). However, the ORR of synovial sarcoma favored pazopanib (<I>p</I> = 0.99). <B><I>Conclusions:</I></B> The efficacies of pazopanib and gemcitabine/docetaxel as second-line treatments after doxorubicin or ifosfamide failure differed among clinical and histologic subgroups and appeared to facilitate a more personalized treatment approach for advanced STS.</P>
TERT promoter mutations and long-term survival in patients with thyroid cancer
Kim, Tae Hyuk,Kim, Young-Eun,Ahn, Soomin,Kim, Ji-Youn,Ki, Chang-Seok,Oh, Young Lyun,Kim, Kyunga,Yun, Jae Won,Park, Woong-Yang,Choe, Jun-Ho,Kim, Jung-Han,Kim, Jee Soo,Kim, Sun Wook,Chung, Jae Hoon Bioscientifica 2016 Endocrine-related cancer Vol.23 No.10
<P><I>TERT</I> promoter mutations are emerging prognostic biomarkers in multiple cancers and are found in highly aggressive thyroid cancer. Our aim is to investigate the prognostic value of these mutations for the outcome of thyroid cancer-related mortality in a large cohort of thyroid cancer patients. This was a retrospective study of 409 patients (393 with differentiated thyroid cancer) with a median age of 44 years (range 16-81 years) and median follow-up of 13 years (interquartile range 11-16 years). Analyses of associations between mutational status and various clinicopathological variables were performed. <I>TERT</I> promoter mutations were identified in 32 (9.8%) papillary, 11 (16.7%) follicular and seven (43.8%) poorly differentiated/anaplastic thyroid cancer patients. The presence of <I>TERT</I> promoter mutations was associated with factors such as increased age (<I>P</I> < 0.001), extrathyroidal invasion (<I>P</I> = 0.01), increased stage at diagnosis (<I>P</I> < 0.001) and dedifferentiated histological type (<I>P</I> = 0.001). A <I>TERT</I> promoter mutation was independently associated with poorer overall survival in patients with differentiated thyroid cancer (10-year survival rate, 66.2% vs 98.3% for wild type; adjusted HR, 7.18; 95% CI: 2.77-18.59) and in patients with papillary cancer (74.2% vs 99.3%; 14.20; 3.03-66.68). Concomitant <I>TERT</I> and <I>BRAF</I> mutations worsened the survival rate of patients with papillary cancer (82.6% vs 99.4% for exclusively <I>BRAF</I> mutation alone; 5.62; 1.85-17.09). In conclusion, the presence of <I>TERT</I> promoter mutations is independently associated with increased mortality in patients with differentiated thyroid cancer. The results suggest that inclusion of <I>TERT</I> promoter mutation analysis with conventional clinicopathological evaluation can lead to better prognostication and management for individual patients.</P>
P-48 A case of diffuse panbronchilitis following bronchiectasis
( Jee Hyuk Kim ),( Seung Yong Park ),( Yeong Hun Choe ),( So Ri Kim ),( Heung Bum Lee ),( Yong Chul Lee ),( Seoung Ju Park ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Diffuse panbronchiolitis (DPB) is characterized by bronchiolitis involved in all layers of the respiratory bronchioles, which show bronchiolectasis in high resolution computed tomography (HRCT). DPB commonly develops in the 2nd-5th decade of life and are slowly progressive over months to years. A 48-year-old man was admitted because of cough, sputum, and dyspnea for 1 month. He had been treated for bronchiectasis, chronic obstructive pulmonary disease, and chronic sinusitis for 1 year in our hospital. Physical examination revealed the inspiratory crackles in both lower lung fields. The chest radiography showed bronchiectasis on the left lower lung and bilateral, diffuse, small nodular shadows which were newly detected findings as compared with those 6 months ago. HRCT revealed diffuse ill-defined nodules up to 3 mm in diameter and nodular and linear opacities in both lobes and cystic bronchiectasis in the right middle lobe, left upper lobe, and left lower lobe. We diagnosed DPB developed in the patient with bronchiectasis and treated with clarithromycin. Untreated bronchiolectasis in DPB can be advanced to induce airway scarring leading to bronchiectasis. Although the causal relationship between DPB and bronchiectasis in our case, we hear report an interesting case of DPB developed in the patient with bronchiectasis.
Jee-Yeon Kim,Jae-Hyuk Ahn,Sung-Jin Choi,Maesoon Im,Sungho Kim,Duarte, J. P.,Chang-Hoon Kim,Tae Jung Park,Sang Yup Lee,Yang-Kyu Choi IEEE 2012 IEEE TRANSACTIONS ON NANOTECHNOLOGY Vol.11 No.2
<P>An underlap channel-embedded FET is proposed for electrical, label-free biosensor in both watery and dry environments, and current-voltage characteristics measured under each environment are compared. To investigate the effectiveness of the underlap device as a biosensor for both environments, antigen-antibody binding of an avian influenza (AI) is used. Antibody of AI binding on antigen-immobilized surface provides additional negative charge on underlap surface, and they give rise to channel potential increasing and result in drain current reduction. In this study, we have verified that the biosensor characteristics measured under dry environment is valid as much as they are valid for watery environment.</P>
Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability
Kim, Hyeongmin,Lee, Jong Hyuk,Kim, Jee Eun,Kim, Young Su,Ryu, Choong Ho,Lee, Hong Joo,Kim, Hye Min,Jeon, Hyojin,Won, Hyo-Joong,Lee, Ji-Yun,Lee, Jaehwi The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3
Ginsenosides, dammarane-type triterpene saponins obtained from ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated. The delivery systems improved the bioavailability of ginsenosides by enhancing solubility, permeability, and stability of the natural products. This mini-review aims to provide comprehensive information on the micro-/nano-sized delivery systems for increasing the bioavailability of ginsenosides, which may be helpful for designing better delivery systems to maximize the versatile therapeutic potential of ginsenosides.
Jee, Bo Young,Kim, Min Sun,Cho, Mi Young,Lee, Soon Jeong,Park, Myung Ae,Kim, Jin Woo,Choi, Seung Hyuk,Jeong, Hyun Do,Kim, Ki Hong The Korean Society of Fisheries and Aquatic Scienc 2014 Fisheries and Aquatic Sciences Vol.17 No.3
RNA interference (RNAi)-mediated transcriptional knock-down of Crassostrea gigas big defensin 1 and 2 genes (Cg-BigDef1 and Cg-BigDef2) was investigated. The cDNA sequences of Cg-BigDef1 and Cg-BigDef2 were identical, excluding an additional fragment of 20 nucleotides in Cg-BigDef1; thus, a long double-stranded RNA (dsRNA) targeting the mRNA of Cg-BigDef2 effectively downregulated both Cg-BigDef2 and Cg-BigDef1. In addition, long dsRNA targeting green fluorescent protein (GFP) did not affect transcription of the two big defensin genes. These results suggest that the transcriptional downregulation of Cg-BigDef1 and Cg-BigDef2 was mediated by sequence-specific RNA interference (RNAi). Despite injection of long dsRNA targeting Cg-BigDef2 into only the adductor muscle, knock-down of Cg-BigDef1 and Cg-BigDef2 was observed in the adductor muscle, hemocytes, mantle, and gills, suggestive of systemic spread of RNAi in C. gigas. Furthermore, the inhibitory effect of dsRNA persisted until 72 h post-injection, indicative of a long-lasting RNAi-mediated knock-down of target genes.
중첩격자를 이용한 제자리비행 로터 해석 코드의 수치특성
김지웅(Jee-Woong Kim),박수형(Soo Hyung Park),유영훈(Yung Hoon Yu),김유진(Eugene Kim),권장혁(Jang Hyuk Kwon) 한국항공우주학회 2008 韓國航空宇宙學會誌 Vol.36 No.8
중첩격자를 이용한 3차원 압축성 Navier-Stokes 코드를 사용하여 정지비행 로터 주위의 유동장을 해석하였다. 후류격자의 간격, 수치기법의 정확도, 난류 모델 등에 따른 유동코드의 수치특성을 확인하였다. 두 가지 형태의 중첩격자 시스템을 사용하여 계산을 수행하였다. 공력 및 끝단 와류의 거동을 Caradonna 동의 실험과 비교하였다. 표면 압력분포 및 끝단 와류의 거동은 실험값과 잘 일치하였다. 적용한 수치해석 기법에 따라 압력분포는 거의 변화가 없는 반면, 후류의 거동은 상당히 큰 편차를 보였다. 자동화된 Cut-paste 알고리즘을 사용한 Chimera 기법을 사용했을 때의 결과는 예상과 달리 기존의 Chimera 기법을 사용하였을 때보다 더 약한 와류 강도를 보였다. A 3-D compressible Navier-Stokes solver using overlapped grids is developed to predict a flow-field around a hovering rotor. The flow solver is verified by a parametric study with the grid spacing of wake grid, spatial accuracy and turbulence model. Computations are performed with different Chimera grid systems. Computational results are compared with the experimental data of Caradonna et al. for both blade loading and the tip vortex behavior. Numerical results show good agreements with experiments for the distribution of surface pressure and tip vortex behavior. Pressure distributions over the blade have marginal differences for different numerical methods, whereas large discrepancies are seen in the prediction of the wake behavior. Results unexpectedly show that the vortex strength from an automated cut-paste Chimera grid is weaker than that from the conventional Chimera grid.
니알브론즈의 기계적 특성에 미치는 알루미늄 및 지르코늄 함량의 영향
안지혁 ( Jee Hyuk Ahn ),김동욱 ( Dong Wook Kim ),김민수 ( Min Soo Kim ),황종현 ( Jong-hyun Hwang ),한승전 ( Seung Zeon Han ) 대한금속재료학회(구 대한금속학회) 2017 대한금속·재료학회지 Vol.55 No.8
To study the effect of Al and Zr contents on the microstructural changes and tensile properties of Ni-Al-Bronze alloy, seven specimens were cast with different Al and Zr contents. The microstructure observation revealed that all specimens were composed of β` and κ phases in a α matrix. With increasing Al and Zr contents, the tensile strength of the Ni-Al-Bronze increased, due to an increase in the β` and κ phase fraction and grain refinement, but the elongation behavior of the Ni-Al-Bronze declined. Furthermore, the excessive addition of Zr caused a reduction in tensile strength and ductility. A successful combination of tensile strength and ductility, 688 MPa-23% was achieved by the controlled addition of Zr to Ni-Al-Bronze. (Received November 10, 2016; Accepted March 13, 2017)