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RISS 인기검색어
- 검색키워드
- 저자 : ( Jaineet Sachdeva ) (검색결과 3 건)
- 무료
- 기관 내 무료
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Deepti Arun Phansopkar,Jaineet Sachdeva,Manmohan Krishan Mahajan,Pamela Alice Kingsley,Shekhar Upadhyay,Rajesh Chakravarti 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.2
Purpose: This study evaluates the dose distribution of tangential beam intensity modulated radiotherapy (IMRT) compared to tangential beam three-dimensional conformal radiotherapy (3D-CRT) in carcinoma breast. Methods: Tangential beam IMRT and tangential beam 3D-CRT plans were generated in 54 postoperative breast cancer patients. Planning target volume (PTV) definition of chest wall and intact breast was done according to Breast Cancer Atlas for Radiation Therapy Oncology Group. The prescribed dose was 50 Gy in 25 fractions. Dose volume histograms was evaluated for PTV and organs at risk, parameters of the dose distribution were compared for 3D-CRT and IMRT using Wilcoxon Matched pairs test. The dosages were clinically correlated with normal tissue reactions. Results: No difference in the conformity index but IMRT improves the homogeneity index significantly (P<0.01). The mean dose to all organs at risk was lesser in IMRT as compared to 3D-CRT of which the dose to contralateral lung was significantly lower with IMRT (111.7 cGy vs. 41.98 cGy, P=0.024). Tangential beam IMRT significantly reduces ipsilateral lung V20% by 24%. Heart V70% is decreased by V74% and V30% by V38% doses but not statistically significant. Conclusion: Tangential beam IMRT in breast cancer offers the potential to significantly reduce the dose-volume of the ipsilateral lung and dose volume of the heart which will translate into decrease in risk of cardiac and lung toxicity and also decreased second cancer risk. IMRT definitely decreases the acute skin reactions in all patients.
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( Preety Srivastava ),( Pamela Alice Kingsley ),( Himanshu Srivastava ),( Jaineet Sachdeva ),( Paramdeep Kaur ) 대한통증학회 2015 The Korean Journal of Pain Vol.28 No.2
Background: To explore the relationship between persistent post-radiotherapy pain and locoregional recurrence in head and neck cancer patients. Methods: Five year retrospective data was reviewed of 86 patients of head and neck cancer treated with radiotherapy who continued to have pain at 6 weeks after completion of treatment. At follow-up after 3 months, these patients were stratified into: Group A (n = 39) constituted of patients whose pain subsided and Group B (n = 47) were patients who continued to have persistent pain. Results: At median follow-up time of 25 months (range: 8.47), one patient (2.6%) and 18 (38.3%) patients in group A and group B had locoregional recurrence respectively (P < 0.0001). Furthermore, group B patients had higher mean pain score levels as compared to group A (P = 0.03). Patients in whom pain subsided within 3 months had statistically much greater disease-free survival in comparison to those with persistent pain (P < 0.0001). Conclusions: Pain in head and neck cancer is an important symptom and should be considered a poor prognostic factor. In the current study, the majority of the patients with persistent pain had recurrent disease as compared to those in whom pain subsided within 3 months of post-treatment. It is suggested that patients with persistent pain need more intense follow-up and should be investigated thoroughly to detect recurrence at an early stage to provide a better quality of life. (Korean J Pain 2015; 28: 116-121)
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Survival of Triple Negative versus Triple Positive Breast Cancers: Comparison and Contrast
Negi, Preety,Kingsley, Pamela Alice,Jain, Kunal,Sachdeva, Jaineet,Srivastava, Himanshu,Marcus, Sudeep,Pannu, Aman Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: Triple negative (TN) and triple positive (TP) breast cancers both are aggressive types but TN generally has a shorter survival. Objectives: To compare the clinical characteristics and treatment outcomes for patients with TN versus TP breast cancer and to assess various prognostic factors affecting overall survival. Materials and Methods: A retrospective audit of 85 breast cancer patients was conducted in the Department of Radiation Oncology and Medical Oncology on patients from 2006 to 2013 for whom IHC for ER, PgR and Her-2 neu were available. The patients were stratified into: ER-, PR- and Her-2 neu- (Arm A, n=47) and ER+, PgR+ and Her-2 neu+ (Arm B, n=38). Results: TN subtype had higher numbers of premenopausal and advanced stage patients as compared to TP subtype. The locoregional recurrence (LRR) and distant metastatic rate was also higher in TN subtype but there was no definite pattern in both the arms. Among the prognostic factors, patients with premenopausal status and advanced stage in TN breast cancer had inferior survival (P=0.07) whereas for those with postmenopausal status and early stage there was no survival difference between the two arms. Conclusions: TN subtype tends to be more aggressive in terms of younger age and advanced stage at presentation, higher tumour grade, LRR and metastasis, suggesting need for future research efforts on providing aggressive treatment to these patients. We could attribute better outcome for TP subtype to receptor positivity enabling role of hormonal treatment and targeted therapy, although less number of patients received targeted therapy.
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