Persistent Post-radiotherapy Pain and Locoregional Recurrence in Head and Neck Cancer- Is There a Hidden Link?

( Preety Srivastava ),( Pamela Alice Kingsley ),( Himanshu Srivastava ),( Jaineet Sachdeva ),( Paramdeep Kaur ) 대한통증학회 2015 The Korean Journal of Pain Vol.28 No.2

Background: To explore the relationship between persistent post-radiotherapy pain and locoregional recurrence in head and neck cancer patients. Methods: Five year retrospective data was reviewed of 86 patients of head and neck cancer treated with radiotherapy who continued to have pain at 6 weeks after completion of treatment. At follow-up after 3 months, these patients were stratified into: Group A (n = 39) constituted of patients whose pain subsided and Group B (n = 47) were patients who continued to have persistent pain. Results: At median follow-up time of 25 months (range: 8.47), one patient (2.6%) and 18 (38.3%) patients in group A and group B had locoregional recurrence respectively (P < 0.0001). Furthermore, group B patients had higher mean pain score levels as compared to group A (P = 0.03). Patients in whom pain subsided within 3 months had statistically much greater disease-free survival in comparison to those with persistent pain (P < 0.0001). Conclusions: Pain in head and neck cancer is an important symptom and should be considered a poor prognostic factor. In the current study, the majority of the patients with persistent pain had recurrent disease as compared to those in whom pain subsided within 3 months of post-treatment. It is suggested that patients with persistent pain need more intense follow-up and should be investigated thoroughly to detect recurrence at an early stage to provide a better quality of life. (Korean J Pain 2015; 28: 116-121)

Bayesian analysis of a repairable system subject to overhauls with bounded failure intensity

Preeti Wanti Srivastava,Nidhi Jain 한국신뢰성학회 2013 International Journal of Reliability and Applicati Vol.14 No.2

This paper deals with the Bayesian analysis of the failure data of a repairable mechanical system subject to minimal repairs and periodic overhauls. The effect of overhauls on the reliability of the system is modeled by a proportional age reduction model and the failure process between two successive overhauls is assumed to be 2-parameter Engelhardt-Bain process (2-EBP). Power Law Process (PLP) model has a disadvantage which 2-EBP can overcome. On the basis of the observed data and of a number of suitable prior densities, point and interval estimation of model parameters, as well as quantities of relevant interest are found. Also hypothesis tests on the effectiveness of performed overhauls have been developed using Bayes factor. Sensitivity analysis of improvement parameter is carried out. Finally, a numerical application is used to illustrate the proposed method.

Impact analysis of neem kernel extracts on the developmental profile of Anopheles stephensi

Preeti Sharma,Lalit Mohan,C.N. Srivastava 한국응용곤충학회 2006 Journal of Asia-Pacific Entomology Vol.9 No.1

evaluation of the larvicidal effi-cacy ofAgeratum conyzoides,Argemone mexicanaand Azadirachta indicawas carried out againstAno-pheles stephensito develop an effective ecofriendlyinsecticide of plant origin. The methanol extract ofA. indicawas observed remarkably active with LC50values 18.2 and 13.1 ppm after 24 and 48 hours ofexposure. Petroleum ether extracts ofAg. conyzoideswith LC50 425.6 and 267.9 pm, carbon tetra chlo-ride extract ofAr. mexicanawith LC50 313.2 and240.3 ppm and petroleum ether extract ofAz. indicawith LC50 189.1 and 53. 5 ppm after 24 and 48hours of exposure were also found effective. Theimpact of Az.indica methanol extract on the lifecycle of malaria vector was further observed. Me-thanol extract of Az.indica causes deformities indifferent developmental stages of the malaria vector.Total developmental period was also extended from10 to 15 It remarkably influenced hatching rates,larval-pupal transformation and development, adultemergence and growth index. Larval and pupalKey words An. stephensi, Ageratum, Argemone,Azadirachta, phytoextract, metamorphosis, larvicide.

Growth Inhibitory Nature of Artemisia annua Extract against Culex quinquefasciatus (Say)

Preeti Sharma,Lalit Mohan,C.N. Srivastava 한국응용곤충학회 2006 Journal of Asia-Pacific Entomology Vol.9 No.4

Petroleum ether (Pee), carbon tetrachloride (Cte) and methanol extract (Mee) of Artemisia annua, Chenopodium album and Sonchus oleraceus were screened for their efficacy against Culex quinquefasciatus larvae. Pee of A. annua, Mee of A. annua and Ch. album, Cte of A. Annua were found effective in descending order after 24 and 48 hrs of treatment. Pee of A. annua, the most potent extract with LC50 78.2 ppm was selected to study its influence on the development and metamorphosis of the culicine mosquito. The extract significantly affected the hatching, larval development, pupal transformation and also lengthened the larval and pupal periods. Growth index was remarkably reduced. Treated culicine eggs, larvae and pupae showed deformities including disruption of the body wall, distorted alimentary canal, damaged tracheal network and arrested histogenesis. The extract has remarkable effect on the metamorphosis and high larvicidal potential, hence, can be used as an effective alternative to the existing synthetic pesticides for the control of Cx. quinquefasciatus.

Role of Photosensitization of Certain Phytotoxins in the Management of Culex quinqueasciatus

Preeti Sharma Rawat,Lalit Mohan,C. N. Srivastava 한국응용곤충학회 2005 한국응용곤충학회 학술대회논문집 Vol.2005 No.05

Comparative Assessment of Diagnostic Performance of Cytochrome Oxidase Multiplex PCR and 18S rRNA Nested PCR

Preeti Kumari,Swati Sinha,Renuka Gahtori,Afshana Quadiri,Paras Mahale,Deepali Savargaonkar,Veena Pande,Bina Srivastava,Himmat Singh,Anupkumar R. Anvikar 대한기생충학ㆍ열대의학회 2022 The Korean Journal of Parasitology Vol.60 No.4

Malaria elimination and control require prompt and accurate diagnosis for treatment plan. Since microscopy and rapid diagnostic test (RDT) are not sensitive particularly for diagnosing low parasitemia, highly sensitive diagnostic tools are required for accurate treatment. Molecular diagnosis of malaria is commonly carried out by nested polymerase chain reaction (PCR) targeting 18S rRNA gene, while this technique involves long turnaround time and multiple steps leading to false positive results. To overcome these drawbacks, we compared highly sensitive cytochrome oxidase gene-based single-step multiplex reaction with 18S rRNA nested PCR. Cytochrome oxidase (cox) genes of P. falciparum (cox-III) and P. vivax (cox-I) were compared with 18S rRNA gene nested PCR and microscopy. Cox gene multiplex PCR was found to be highly specific and sensitive, enhancing the detection limit of mixed infections. Cox gene multiplex PCR showed a sensitivity of 100% and a specificity of 97%. This approach can be used as an alternative diagnostic method as it offers higher diagnostic performance and is amenable to high throughput scaling up for a larger sample size at low cost.

Design of ramp-stress accelerated life test plans for a bridge network

Preeti Wanti Srivastava,Savita 한국신뢰성학회 2018 International Journal of Reliability and Applicati Vol.19 No.2

The study of complex networks play an important role in many fields of technical. The system having no simple interconnections is called System with Complex Interconnection. In this paper, we have formulated optimum Accelerated life test(ALT) plan for a bridge network with independent components under ramp-stress loading scheme and Type-I censoring. In reliability theory, redundancy is understood as using additional units for replacement/substitution of failed units. A Bridge network structure is a kind of structural redundancy wherein failure of one component does not lead to failure of the system due to its redundant structure. Well known example of a bridge structure is Wheatstone bridge. The failure times of the system components are assumed to be exponential. The stress-life relationship is modeled using inverse power law, and cumulative exposure model is assumed to model the effect of changing stress. The optimal plan consists in finding out the optimum stress rate using D-optimality criterion. The method developed has been explained using a numerical example and sensitivity carried out.

Impact Analysis of Neem Kernel Extracts on the Developmental Profile of Anopheles stephensi

Sharma, Preeti,Mohan, Lalit,Srivastava, C.N. Korean Society of Applied Entomology 2006 Journal of Asia-Pacific Entomology Vol.9 No.1

Laboratory evaluation of the larvicidal efficacy of Ageratum conyzoides, Argemone mexicana and Azadirachta indica was carned out against Anopheles stephensi to develop an effective ecofriendly insecticide of plant origin. The methanol extract of A. indica was observed remarkably active with $LC_{50}$ values 18.2 and 13.1 ppm after 24 and 48 hours of exposure. Petroleum ether extracts of Ag. conyzoides with $LC_{50}$ 425.6 and 267.9 ppm, carbon tetra chloride extract of Ar. mexicana with $LC_{50}$ 313.2 and 240.3 ppm and petroleum ether extract of Az. indica with $LC_{50}$ 189.1 and 53. 5 ppm after 24 and 48 hours of exposure were also found effective. The impact of Az. indica methanol extract on the life cycle of malaria vector was further observed. Methanol extract of Az. indica causes deformities in different developmental stages of the malaria vector. Total developmental period was also extended from 10 to 15 It remarkably influenced hatching rates, larval-pupal transformation and development, adult emergence and growth index. Larval and pupal periods were also significantly prolonged.

Growth Inhibitory Nature of Artemisia annua Extract against Culex quinquefasciatus (Say)

Shaema, Preeti,Mohan, Lalit,Srivastava, C.N. Korean Society of Applied Entomology 2006 Journal of Asia-Pacific Entomology Vol.9 No.4

Petroleum ether (Pee), carbon tetrachloride (Cte) and methanol extract (Mee) of Artemisia anmua, Chenopodium album and Sonchus oleraceus were screened for their efficacy against Culex quinquefasciatus larvae. Pee of A. annua, Mee of A. annua and Ch. album, Cte of A. Annua were found effective in descending order after 24 and 48 hrs of treatment. Pee of A. annua, the most potent extract with $LC_{50}\;78.2\;ppm$ was selected to study its influence on the development and metamorphosis of the culicine mosquito. The extract significantly affected the hatching, larval development, pupal transformation and also lengthened the larval and pupal periods. Growth index was remarkably reduced. Treated culicine eggs, larvae and pupae showed deformities including disruption of the body wall, distorted alimentary canal, damaged tracheal network and arrested histogenesis. The extract has remarkable effect on the metamorphosis and high larvicidal potential, hence, can be used as an effective alternative to the existing synthetic pesticides for the control of Cx. quinquefasciatus.

Larvicidal activity of Pseudocalymma alliaceum and Allium sativum against Culex quinquefasciatus (Say)

Shrankhla,Preeti Sharma,Lalit Mohan,Chand Narayan SRIVASTAVA 한국곤충학회 2011 Entomological Research Vol.41 No.6

The larvicidal activity of the plant extracts Pseudocalymma alliaceum and Allium sativum were determined against Culex quinquefasciatus. The hexane extract of P. alliaceum and the petroleum ether extract of A. sativum exhibited larvicidal efficacy against Cx. quinquefasciatus larvae. Extracts of P. alliaceum resulted in concentrations that produced 50% mortality LC_50 and LC_90 values of 2.49 and 15.06 ppm, respectively, after 24 h and 1.16 and 8.45 ppm after 48 h. Extracts of A. sativum resulted in LC_50 and LC_90 values of 8.38 and 29.15 ppm after 24 h and 7.28 and 44.19 ppm after 48 h of exposure, respectively. The results indicate that the plant extract component(s) present in the hexane extract of P. alliaceum leaves demonstrated greater potential as an efficient larvicide than A. sativum against Cx. quinquefasciatus.