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RISS 인기검색어
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- 저자 : ( Jacobo Sellares ) (검색결과 2 건)
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Mesenchymal stem cells reduce ER stress via PERK-Nrf2 pathway in an aged mouse model
이은주,( Nayra Cárdenes ),( Diana Álvarez ),( Jacobo Sellares ),( John Sembrat ),( Paola Aranda ),( Yating Peng ),( Jordan Bullock ),( Seyed Mehdi Nouraie ),( Ana L Mora ),( Mauricio Rojas ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Mesenchymal stem cells (MSCs) have been shown to ameliorate the deleterious effects of bleomycin. However, the mechanism responsible for protection of stem cell therapy in pulmonary fibrosis is still poorly understood, especially in terms of the endoplasmic reticulum (ER) stress. We hypothesized that ER stress could increase after a certain time elapse and then decrease to the baseline, resembling the fibrosis after bleomycin exposure. We also attempted to clarify the exact role of MSCs upon ER stress by a timely sacrifice of animals at the peak of ER stress. In order to determine the peak time in ER stress, the expression of ER stress marker proteins after bleomycin injury were measured in the lung of old mice at different time points (day 0, 3, 7, 14, and 21). For evaluation of the effect of MSCs on ER stress, we assessed the bleomycin insult by changes in body weight, lung tissues histology and the protein expression of ER stress markers. The level of expression of unfolded protein response (UPR) transcription factor XBP-1 and its regulator BiP were elevated at day 7 and progressively increased up to day 21. MSCs inhibited BiP expression in bleomycin-induced ER stress, whereas the expression levels of other ER stress markers were not reduced by MSCs. MSCs operate on ER stress via several pathways, but the PERK-Nrf2 pathway revealed to be the main functioning pathway. In conclusion, we demonstrated that MSCs attenuate ER stress via PERK-Nrf2 pathway.
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( Pilar Brito Zeron ),( Marta Perez De Lis Novo ),( Roberto Perez Alvarez ),( Jacobo Sellares ),( Soledad Retamozo ),( Xavier Bosch ),( Fernanda Hernandez ),( Josep Manel Santos ),( Antoni Siso Almira 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To analyse the infi uence of the epidemiological profi le in the disease expression of a large series of patients with sarcoidosis. Methods: Study cohort including 160 patients diagnosed with sarcoidosis in the last 10 years. The diagnosis of sarcoidosis was based on clinical criteria and imaging studies, together with the histopathological demonstration of non-necrotizing granulomas, and excluding other granulomatous diseases, mainly infectious (tuberculosis). Results: There were 106 women and 54 men, with a mean age at diagnosis of 46.87 years. The main clinical manifestations present at diagnosis were respiratory symptoms (40%), followed by general symptoms (31%), skin lesions (29%) and the incidental fi nding of imaging fi ndings in asymptomatic patients (18%). 37% of patients had adisease onset <40 years. This early onset of disease was reported mainly in males (44% vs 28%, p=0.027) and was associated with a higher frequency of general symptoms (42% vs 25%, p=0.023), erythema nodosum (29% vs 16%, p=0.041), uveitis (14% vs. 5%, p=0.05) and joint involvement (17% vs 5%, p=0.014), but with a lower frequency of interstitial lung disease (25% vs 42%, p=0.028) and splenic involvement (0% vs 7%, p=0.037). With respect to the differential presentation of the disease according to gender, women diagnosed with sarcoidosis had a higher mean age at diagnosis (48.8 vs 42.8 years, p=0.017), a higher frequency of skin involvement (35% vs 13%, p=0.003) and a lower frequency of pulmonary (34% vs 52%, p=0.022), hepatosplenic (2% vs 9%, p=0.044) and nervous system (3% vs 13%, p=0.032) involvements in comparison with males. Conclusions: An early disease onset (<40 years) was mainly associated with general and cutaneous involvement, while sarcoidosis in men affects more frequently vital organs.
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