Anovel functional polymorphism in CIR1gene is associated with the risk of lung cancer

( Hyera Kim ),( Jineun Choi ),( Sun Ha Choi ),( Minjung Kim ),( Hyewon Seo ),( Yong Dae Lee ),( So Yeon Lee ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Jae 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

Purpose: We evaluated the associations between potentially functional variants in cancer-related genes and the risk of lung cancer to identify genetic factors responsible for lung cancer susceptibility in a Korean population. Material and Methods: A total of 1,969 potentially functional single nucleotide polymorphisms (SNPs) of 1,151 genes involved in carcinogenesis were evaluated using the Affymetrix custom-made GeneChipin 610 NSCLC patients and 610 healthy controls. A replication study was performed on an independent set of 490 cases and 486 controls. Results: Eighty two SNPs with P< 0.05 for genotype distribution in the discovery set were tested in the replication study. Among the 82 SNPs, three SNPs (corepressor interacting with RBPJ 1 [CIR1] SNP1T>C,solute carrier family 38, member 4[SLC38A4] SNP2C>T, ribonucleotide reductase M1 [RRM1] SNP3T>C) constantly showed significant associations with lung cancer(adjusted odds ratio[aOR] = 0.68, 95% CI = 0.59-0.84, P < 0.0001; aOR = 0.74, 95% CI = 0.63-0.88, P = 0.001;aOR = 0.72, 95% CI = 0.56-0.93, P = 0.01, respectively, under dominant model). Promoter assay demonstrated a decreased reporter gene expression for CIR1SNP1 C allele was observed compared with T allele (P = 0.02). Conclusions: Our results suggest that the three SNPs, particularly CIR1SNP1T>C, may contribute to lung cancer susceptibility in Koreans.

Clinical Relevance of Bronchial Anthracofibrosis in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

( Hyera Kim ),( Seung Ick Cha ),( Kyung Min Shin ),( Jae Kwang Lim ),( Se Rim Oh ),( Min Jung Kim ),( Yong Dae Lee ),( Mi Young Kim ),( Jae Hee Lee ),( Chang Ho Kim ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3

Background: Bronchial anthracofibrosis (BAF), which is associated with exposure to biomass smoke in inefficiently ventilated indoor areas, can take the form of obstructive lung disease. Patients with BAF can mimic or present with an exacerbation of chronic obstructive pulmonary disease (COPD). The purpose of the current study was to investigate the prevalence of BAF in Korean patients with COPD exacerbation as well as to examine the clinical features of these patients in order to determine its clinical relevance. Methods: A total of 206 patients with COPD exacerbation were divided into BAF and non-BAF groups, according to computed tomography findings. We compared both clinical and radiologic variables between the two groups. Results: Patients with BAF (51 [25%]) were older, with a preponderance of nonsmoking women; moreover, they showed a more frequent association with exposure to wood smoke compared to those without BAF. However, no differences in the severity of illness and clinical course between the two groups were observed. Patients in the BAF group had less severe airflow obstruction, but more common and severe pulmonary hypertension signs than those in the non-BAF group. Conclusion: Compared with non-BAF COPD, BAF may be associated with milder airflow limitation and more frequent signs of pulmonary hypertension with a more severe grade in patients presenting with COPD exacerbation.

Clinical Relevance of Bronchial Anthracofibrosis in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

Kim, Hyera,Cha, Seung-Ick,Shin, Kyung-Min,Lim, Jae-Kwang,Oh, Serim,Kim, Min Jung,Lee, Yong Dae,Kim, Miyoung,Lee, Jaehee,Kim, Chang-Ho The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3

Background: Bronchial anthracofibrosis (BAF), which is associated with exposure to biomass smoke in inefficiently ventilated indoor areas, can take the form of obstructive lung disease. Patients with BAF can mimic or present with an exacerbation of chronic obstructive pulmonary disease (COPD). The purpose of the current study was to investigate the prevalence of BAF in Korean patients with COPD exacerbation as well as to examine the clinical features of these patients in order to determine its clinical relevance. Methods: A total of 206 patients with COPD exacerbation were divided into BAF and non-BAF groups, according to computed tomography findings. We compared both clinical and radiologic variables between the two groups. Results: Patients with BAF (51 [25%]) were older, with a preponderance of nonsmoking women; moreover, they showed a more frequent association with exposure to wood smoke compared to those without BAF. However, no differences in the severity of illness and clinical course between the two groups were observed. Patients in the BAF group had less severe airflow obstruction, but more common and severe pulmonary hypertension signs than those in the non-BAF group. Conclusion: Compared with non-BAF COPD, BAF may be associated with milder airflow limitation and more frequent signs of pulmonary hypertension with a more severe grade in patients presenting with COPD exacerbation.

Profiling of the Major Phenolic Compounds and Their Biosynthesis Genes in <i> Sophora flavescens</i> Aiton

Lee, Jeongyeo,Jung, Jaeeun,Son, Seung-Hyun,Kim, Hyun-Bi,Noh, Young-Hee,Min, Sung Ran,Park, Kun-Hyang,Kim, Dae-Soo,Park, Sang Un,Lee, Haeng-Soon,Kim, Cha Young,Kim, Hyun-Soon,Lee, Hyeong-Kyu,Kim, HyeRa Hindawi 2018 The Scientific World Journal Vol.2018 No.-

<P>Sophorae Radix (<I>Sophora flavescens </I>Aiton) has long been used in traditional medicine in East Asia due to the various biological activities of its secondary metabolites. Endogenous contents of phenolic compounds (phenolic acid, flavonol, and isoflavone) and the main bioactive compounds of Sophorae Radix were analyzed based on the qualitative HPLC analysis and evaluated in different organs and at different developmental stages. In total, 11 compounds were detected, and the composition of the roots and aerial parts (leaves, stems, and flowers) was significantly different. trans-Cinnamic acid and<I> p</I>-coumaric acid were observed only in the aerial parts. Large amounts of rutin and maackiain were detected in the roots. Four phenolic acid compounds (benzoic acid, caffeic acid, ferulic acid, and chlorogenic acid) and four flavonol compounds (kaempferol, catechin hydrate, epicatechin, and rutin) were higher in aerial parts than in roots. To identify putative genes involved in phenolic compounds biosynthesis, a total of 41 transcripts were investigated. Expression patterns of these selected genes, as well as the multiple isoforms for the genes, varied by organ and developmental stage, implying that they are involved in the biosynthesis of various phenolic compounds both spatially and temporally.</P>

Predictors of Relapse in Patients with Organizing Pneumonia

Kim, Minjung,Cha, Seung-Ick,Seo, Hyewon,Shin, Kyung-Min,Lim, Jae-Kwang,Kim, Hyera,Yoo, Seung-Soo,Lee, Jaehee,Lee, Shin-Yup,Kim, Chang-Ho,Park, Jae-Yong The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. Methods: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). Results: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), $PaO_2/FiO_2$, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively). Conclusion: This study shows that FVC, $PaO_2/FiO_2$ and serum protein level at presentation can significantly predict relapse in OP patients.

Predictors of Relapse in Patients with Organizing Pneumonia

( Minjung Kim ),( Seung Ick Cha ),( Hyewon Seo ),( Kyung Min Shin ),( Jae Kwang Lim ),( Hyera Kim ),( Seung Soo Yoo ),( Jaehee Lee ),( Shin Yup Lee ),( Chang Ho Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. Methods: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). Results: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), PaO2/FiO2, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively). Conclusion: This study shows that FVC, PaO2/FiO2 and serum protein level at presentation can significantly predict relapse in OP patients.

서유럽 축제에서 감지되는 컨템포러리 춤 경향 분석(2015~2018)

김혜라 ( Hyera Kim ) 대한무용학회 2020 대한무용학회논문집 Vol.78 No.1

This research analyzes the aim of productions of the West Europe dance festivals in order to understand the dance trends recently (2015~2018) shown in West Europe by finding three major characteristics. The use of storytelling language in dance pieces has increased. Also, there is an increase in the use of grotesque expressions using multimedia, furthering boundaries of dancing bodies. Lastly, many works focus on the primitive emotions of humans, on pure movement itself, reminding us of the fundamental life of dance. The understanding of how today’s contemporary dance is changing is essential for choreographers and researchers.

전기화학적 효소면역센서

김민선,장봉화,허성민,신혜라,남학현,차근식 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

정서공감과 우울의 관계

최혜라(Hyera Choi),한수미(Sumi Han),김환(Hwan Kim) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.2

우울한 사람들은 슬픔에 빠져 있고 부정적인 측면에 대해 반추하므로 외부를 향한 관심이나 반응성은 저하되는 경향이 있다. 타인에 대한 관심과 반응성을 기반으로 하는 행동이라 볼 수 있는 공감에 있어서 우울한 사람이 어떠한 특성을 보일지에 대한 의문을 가지고, 본 연구에서는 146명의 온라인 대학생들로부터 자료를 얻어 공감과 우울의 관계에 대해 살펴보았다. 상관분석 결과, 공감의 인지적 측면인 조망수용은 우울과 부적상관을 나타냈고, 공감의 정서적 측면 중 공감적 반응과 공감적 관심 역시 우울과 부적 상관을 나타냈다. 그러나 또 다른 정서 공감의 지표인 개인적 고통의 경우 우울과 정적상관을 나타냈다. 공감 관련 변인들을 예측변인으로 설정한 회귀분석에서는 조망수용이 우울에 부적 영향을, 개인적 고통이 우울에 정적 영향을 미치는 것으로 나타났다. 개인적 고통이 자기비난을 매개로 하여 우울에 영향을 미친다는 가설을 다중회귀분석과 Sobel 검사를 통해 확인해 보았는데, 자기비난은 개인적 고통의 정적 효과를 완전 매개하는 것으로 나타났다. 이러한 결과를 바탕으로 본 연구의 함의와 제한점에 대해 논하였다. While depressives tend to be preoccupied with their own grief and the negative aspects, they might lack the capacity to interact with outside world. With the intention to determine whether depressives might have certain characteristics regarding empathic behavior, as behavior is highly based on responsiveness to others, we examined the relationship between emotional empathy and depression. In addition, we examined the mediating effect of self-criticism on the relationship between emotional empathy and depression. Data was collected from 146 online university students and analyzed using the correlation and multiple regression model. Results showed that perspective taking, which is the cognitive aspect of empathy, was negatively correlated with depression. Concerning the emotional aspects of empathy, both empathic responding and empathic concern were negatively correlated with depression, while personal distress was positively correlated with depression. Regression results, which set the empathy related variables as predicting variables, found perspective taking decreased depression, and personal distress enhanced depression. In addition, personal distress showed significant enhancing effect on depression and was completely mediated by self-criticism. With the result, implications and limitations of this study were discussed.

서비스직과 비서비스직의 감정노동 및 감정노동이 우울과 삶의 질에 미치는 영향

김환(Hwan Kim),한수미(Sumi Han),최혜라(Hyera Choi) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.4

감정노동이란 직업적인 요구에 맞춰 감정을 조절하여 표현하는 것을 말한다. 그간 서비스 근로자의 감정노동 특징이나 관련 요인에 대한 연구는 다양하게 이뤄졌으나 서비스 근로자와 비서비스 근로자의 감정노동을 비교한 연구가 많지 않았으므로, 본 연구에서는 근로자의 유형을 나누어 감정노동의 차이를 검증해보고자 하였다. 또한 감정노동의 부정적인 결과로 알려져 있는 우울과 삶의 질 저하에도 관심을 가지고 이들에게서 나타나는 우울, 삶의 질과 감정노동 간의 관계에 대해서도 알아보고자 하였다. 이러한 목적으로 125명의 서비스 근로자와 사이버대학교에 재학 중인 186명의 온라인 대학생 자료를 수집하였으며, 온라인 대학생의 경우 비서비스직 임을 확인하기 위하여 관리자, 군인 및 주부로 대상의 직업을 제한하였다. 집단 차를 알아보기 위해 일원변량분석에 더불어 사후분석으로 Fisher의 LSD를 실시하였다. 고객응대의 과부하 요인은 서비스직에서 다른 세 집단에 비해 높았고 감정조절의 요구와 규제, 감정 부조화, 우울은 서비스직과 주부 집단에서 높게 나타났다. 다중회귀분석의 시행 결과로는 감정부조화가 우울을 상승시키고 삶의 질을 저하시키는 영향이 있는 한편, 지지와 보호는 삶의 질을 향상시키고 우울은 저하시키는 효과가 나타났다. 이러한 결과를 토대로 연구의 함의와 제한점에 대해 논하였다. Emotional labor is the process of regulating feelings or emotions and expressing them in the way that fulfill job requirement. There have been many studies about characteristics or related variables of service workers’ emotional labor, but are few studies comparing emotional labor between service workers and non-service workers. Therefore we are to examine the differences of emotional labor among the different types of workers. And as depression and lowered quality of life are well known negative consequences of emotional labor, we also intend to study the relationship between depression, quality of life, and emotional labor. Data were collected from 125 sales workers, and 186 cyber university full time students. And as to assure the student participants to be non-service workers, we limited the participant job as administrator, soldier or housewife. To compare differences of groups, one-way ANOVA was performed with Fisher’s LSD as post hoc comparison. On overload in customer reception, service workers showed significantly higher scores, and on demand of emotional regulation/emotional dissonance/depression, both service workers and housewives showed significantly higher scores. Also analysis of multiple regression was performed, and the result showed that, emotional dissonance increased depression but decreased quality of life, while support/care increased quality of life, but decreased depression. With the result, implications and limitations of this study were discussed.