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Jang, Holim,Srichayet, Phisamai,Park, Woo Jung,Heo, Ho Jin,Kim, Dae-Ok,Tongchitpakdee, Sasitorn,Kim, Tae-Jin,Jung, Sang Hoon,Lee, Chang Yong ELSEVIER SCIENCE B.V.; AMSTERDAM 2017 JOURNAL OF FUNCTIONAL FOODS Vol.37 No.-
<P><B>Abstract</B></P> <P>This study was to evaluate the protective effect of <I>Phyllanthus emblica</I> L. (Indian gooseberry) on retinal degeneration in a well-characterized animal model of Alzheimer’s disease. RGC-5 cells were treated with Indian gooseberry extract (IGE), and intracellular antioxidant activity was evaluated. IGE was orally administered to mice for 21days, then amyloid beta (Aβ) was administered by intracerebroventricular injection to induce neuronal damage in the brain and retina, and enucleated eyes were collected from the mice and analyzed using western blots and histological assays. As a result, we found that IGE inhibited intracellular oxidative stress and reduced the severity of histological changes caused by Aβ-induced retinal degeneration in retinal tissue. Furthermore, it regulated the levels of neurofilament (NF)-L, thymocyte differentiation antigen 1 (Thy-1), and sirtuin 1 (SIRT1) in the retina. These findings demonstrate that IGE protects against retinal degeneration and suggest that this effect is attributable to its antioxidant properties.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Intracerebroventricular (ICV) administration of amyloid beta (Aβ) causes retinal degeneration <I>in vivo</I>. </LI> <LI> Indian gooseberry extract (IGE) protects the retina against Aβ-induced retinal damage in mice. </LI> <LI> IGE regulates the levels of NF-L, Thy-1, and SIRT1 in mice retina. </LI> </UL> </P>
Chlorogenic Acid and Coffee Prevent Hypoxia-Induced Retinal Degeneration
Jang, Holim,Ahn, Hong Ryul,Jo, Hyoung,Kim, Kyung-A,Lee, Eun Ha,Lee, Ki Won,Jung, Sang Hoon,Lee, Chang Y. American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.1
<P>This study explored whether chlorogenic acid (CGA) and coffee have protective effects against retinal degeneration. Under hypoxic conditions, the viability of transformed retinal ganglion (RGC-5) cells was significantly reduced by treatment with the nitric oxide (NO) donor <I>S</I>-nitroso-<I>N</I>-acetylpenicillamine (SNAP). However, pretreatment with CGA attenuated cell death in a concentration-dependent manner. In addition, CGA prevented the up-regulation of apoptotic proteins such as Bad and cleaved caspase-3. Similar beneficial effects of both CGA and coffee extracts were observed in mice that had undergone an optic nerve crush (ONC) procedure. CGA and coffee extract reduced cell death by preventing the down-regulation of Thy-1. Our <I>in vitro</I> and <I>in vivo</I> studies demonstrated that coffee and its major component, CGA, significantly reduce apoptosis of retinal cells induced by hypoxia and NO, and that coffee consumption may help in preventing retinal degeneration.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-1/jf404285v/production/images/medium/jf-2013-04285v_0008.gif'></P>
( Chi Heung Cho ),( Holim Jang ),( Migi Lee ),( Hee Kang ),( Ho Jin Heo ),( Dae-ok Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.7
The present study was carried out to investigate the antioxidative and neuroprotective effects of sea buckthorn (Hippophae rhamnoides L.) leaves (SBL) harvested at different times. Reversed-phase high-performance liquid chromatography analysis revealed five major phenolic compounds: ellagic acid, gallic acid, isorhamnetin, kaempferol, and quercetin. SBL harvested in August had the highest total phenolic and flavonoid contents and antioxidant capacity. Treatment of neuronal PC-12 cells with the ethyl acetate fraction of SBL harvested in August increased their viability and membrane integrity and reduced intracellular oxidative stress in a dose-dependent manner. The relative populations of both early and late apoptotic PC-12 cells were decreased by treatment with the SBL ethyl acetate fraction, based on flow cytometry analysis using annexin V-FITC/PI staining. These findings suggest that SBL can serve as a good source of antioxidants and medicinal agents that attenuate oxidative stress.
Lee, Hyunah,Ha, Min Jung,Shahbaz, Hafiz Muhammad,Kim, Jeong Un,Jang, Holim,Park, Jiyong Elsevier 2018 Journal of food engineering Vol.238 No.-
<P><B>Abstract</B></P> <P>The traditional process of manufacturing red bean powder (RBP) using high temperature and extensive cooking causes quality changes, such as an off-flavor, destruction of colors, and a reduced nutritional value of the product. In this study, RBP was manufactured using a novel process of wet grinding, high hydrostatic pressure (HHP), and freeze-drying. The impact of HHP treatment in this innovative manufacturing process on the microbial count, antioxidant activity, anti-nutritional factors, and physicochemical properties of RBP was evaluated by comparison with the conventional method of thermal treatment. Microbial populations in final RBP were reduced to 1.83, 1.55, and 1.05 log CFU/g when treated using HHP 400, 500, and 600 MPa, respectively. HHP treatment improved the nutritional profile and reduced the effects of anti-nutritional factors in RBP. The most effective reduction of trypsin inhibitor activity and phytic acid content was achieved using HHP at 600 MPa for 5 min. Total phenols, flavonoids, proanthocyanidins and total antioxidant capacity in HHP treated RBP were more effectively preserved than in thermally treated RBP. Preparation of RBP using a novel manufacturing process involving HHP treatment rather than a thermal treatment improved physico-chemical and functional properties and enhanced microbiological safety.</P> <P><B>Highlights for review</B></P> <P> <UL> <LI> Red bean powder was manufactured using a novel process. </LI> <LI> Process included wet grinding, high hydrostatic pressure (HHP), and freeze-drying. </LI> <LI> HHP effectively disinfected naturally occurring microorganisms in red bean powder. </LI> <LI> Nutritional and functional properties of red bean powder were effectively preserved. </LI> </UL> </P>
Ahn, Hong Ryul,Lee, Hee Ju,Kim, Kyung-A,Kim, Chul Young,Nho, Chu Won,Jang, Holim,Pan, Cheol-Ho,Lee, Chang Yong,Jung, Sang Hoon American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.6
<P>We investigated the effects of an ethanol extract of <I>C. denticulatum</I> (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against <I>N</I>-methyl-<SMALL>d</SMALL>-aspartate-induced damage to the rat retinas. <I>In vitro</I>, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(<I>S</I>,<I>R</I>)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both <I>in vitro</I> and <I>in vivo</I> studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-6/jf4046232/production/images/medium/jf-2013-046232_0012.gif'></P>