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- 저자 : ( Hasan Besim ) (검색결과 2 건)
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Efficacy of Platelet-Rich Fibrin on Bile Duct Anastomosis in a Rat
( Necdet Ozcay ),( Ali Ozant ),( Hanife Ozkayalar ),( Hasan Besim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Promoting the healing process and increasing the regen erative capacity of the biliary system might play a crucial role in preventing biliary complications following hepatopancreaticobi liary operations and liver transplantation. Aim of the study is to evaluate the effect of platelet-rich-fibrin (PRF) concentrate on the bile duct anastomosis healing process in rats. Methods: Thirty male Sprague Dawley (SD) rats were used for the study. The animals were allocated into three groups: Group I Control Group (n=10): Anastomosis to the common bile duct (CBD) with a stent. Group II PRF Group (n=10): Anastomosis to the CBD with a stent and covered with PRF. Group III Sham Group (n=10): Preparation of the common bile duct, no anas tomosis. The animals were followed up for 1 month, then sac rificed. Study parameters were adhesions around the anasto mosis, bridging the bile duct tissue thickness over the stent and histopathologic examination of the bridging bile duct tissue. Results: CBD anastomosis using a stent caused severe adhesion around the anastomosis, bridging bile duct tissues were weak and histopathologically, healing was incomplete in most of the control animals. However, PRF application significantly reduced the adhesions, increased the quality of the bridging bile duct tissues and caused complete healing histologically. Conclusions: PRF is a safe, autologous, easily prepared mem brane. The present study findings shows that PRF prevents local complications, and increases the healing capacity of the bile duct after CBD anastomosis. Therefore, it might be a new treatment option for preventing bile duct complications in liver transplantation patients.
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Bas, Koray,Guler, Tolga,Gunay, Levent Mert,Besim, Hasan,Uygur, Dilek Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
To date, there was no controlled-study regarding awareness and knowledge of colorectal cancer in the Turkish population. We therefore designed a questionnaire consisting of items related to socio-demographic parameters, medical and family history and questions of awareness and knowledge about colorectal cancer for use in a descriptive cross-sectional study. An interviewer-administered technique was applied and 450 subjects were interviewed in the outpatient clinics at Near East University Hospital. Among all subjects, 337 were found to be eligible for the study group. Exclusion criteria were age below 18 years, any cancer history, family history of colorectal cancer, current colorectal problems, history of any diagnostic or therapeutic interventions for colorectal diseases. All participants stated that they heard about colorectal cancer. When asked about the lifetime risk of colorectal carcinoma, only 25.4% of women and 37.9% of men estimated correctly. Univariate analysis revealed that the total awareness score was significantly correlated with age, marital status, parenthood and fecal occult blood testing history. On multivariate analysis of independent predictors for awareness of colorectal cancer were found to be history of fecal occult blood testing, age and marital status were found to be the most important determinants. As a conclusion, opportunistic screening with fecal occult blood test by physicians from non-gastrointestinal specialties not only helps to reduce the mortality but also increases the awareness of colorectal cancer.
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