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RISS 인기검색어
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- 저자 : ( Hai-su Dai ) (검색결과 3 건)
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Su, Xiang-Yu,Yin, Hai-Tao,Li, Su-Yi,Huang, Xin-En,Tan, Hua-Yang,Dai, Hong-Yu,Shi, Fang-Fang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Objective: To study synergistic effects of nedaplatin and cisplatin on three human carcinoma cell lines (esophageal carcinoma cell line Eca-109, ovarian carcinoma Skov-3 and cervical carcinoma Hela). Methods: Inhibition effects were evaluated by MTT assay and cell apoptosis was detected by flow cytometry. In addition, changes of Ki-67, Bax and Bcl-2 at mRNA and protein levels were quantified by RT-PCR and Western blotting. Results: Growth inhibition in each cell lines was dose-dependent after exposure to nedaplatin or cisplatin alone. The interaction of the two drugs was synergistic at higher concentrations according to the median-effect principle. The inhibition rates with nedaplatin, cisplatin and combined treatment were $41.9{\pm}4.1%$, $47.4{\pm}2.9%$, $52.5{\pm}0.9%$(Eca-109), $39.0{\pm}1.26%$, $45.0{\pm}1.45%$, $56.2{\pm}1.44%$ (Skov-3) and $44.8{\pm}2.11%$, $46.9{\pm}0.99%$, $56.6{\pm}1.83%$ (Hela) respectively, with increase in apoptosis. Compared with the nedaplatin or cisplatin alone treatment group, the combinative treatment group's Ki-67 and bcl-2 mRNA (protein) expression was decreased while that of Bax mRNA (protein) was increased. Conclusion: Compared to the effects of nedaplatin or cisplatin alone at high concentrations, combination of nedaplatin and cisplatin at low concentrations proved to be much more effective for inhibition of proliferation and the induction of apoptosis in the Eca-109, Skov-3 and Hela cell lines.
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부신 갈색세포종에서 시행한 복강경하 부신절제술 : 초기경험 2예 Initial two Experiences
박수환,김성우,최대해,김대곤,이경섭,서영진 東國大學校醫學硏究所 2005 東國醫學 Vol.12 No.2
부신절제술은 재원기간, 술 후 통증, 미용적 장점 등에 있어 복강경 수술이 가장 효과적인 방법으로 보편화 되어 있다. 이에 저자들은 부신 갈색세포종환자의 복강경하 부신절제술 2예에 대한 임상경험을 보고하고자 한다. 첫 번째 증례는 28세 여자환자로 간헐적인 두통을 주소로 내원하였으며 술 전 6.5×6.0×5.6cm의 우측의 부신 갈색세포종으로 진단되어 복강경하 부신절제술을 시행하였다. 두 번째 증례는 51세 여자환자로 고혈압을 주소로 내원하였으며 술 전 5.6×4.5×4.4cm의 우측의 부신 갈색세포종으로 진단되어 복강경하 부신절제술을 시행하였다. 두 환자 모두 전신마취하에 측와위에서 복강을 통하여 시행하였다. 총 4개의 포트를 유치하였으며 간과 신장 상극을 박리한 후 부신정맥이 위치하는 내측부위의 박리를 시작하여 부신절제술을 시행하였다. 두 환자의 수술 시간은 각각 275, 255분 이었으며, 수술시 실혈량은 각각 110, 100cc였다. 술 후 재원기간은 각각 6일과 5일이었으며 술 중 및 술 후 합병증은 없었다. 복강경하 부신절제술은 부신 갈색세포종의 치료에 있어 안전하고 효과적인 치료법이라 생각된다. Laparoscopic adrenalectomy is very effective and generalized treatment because of short term hospital stay, less post operative pain and cosmetic effect. So. we presented the experience about two experiences of laparoscopic adrenalectomy in pheochromocytoma. In the first case, a 28 years old woman was hospitalized for the evaluation of intermittent headache and we found a 6.5×6.0×5.6 ㎝ sized tumor at the right adrenal and laparoscopic adrenalectomy was performed. In the second case, a 51 years old woman was hospitalized for the evaluation of hypertension. We found a right adrenal tumor. measuring 5.6×4.5×4.4 ㎝ and laparoscopic adrenalectomy was performed. Under the general anesthesia, we took this procedure to patients who were lateral positioned with transperitoneal approach. Using the 4 laparoscopic port, completed adrenalectomy was performed through the dissection of liver, upper pole of right kidney, and adrenal vein. It took 275 minutes and 255 minutes and intra—operative blood loss was about 110 ㎖ and 100 ㎖l respectively. The hospital stay was 6 days and 5 days, respectively. There was not any complications during and alter operation. Laparoscopic approach to the patient was technically safe and efficient therapy for adrenal pheochromocytoma.
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( Tian Yang ),( Hai-su Dai ),( Lei Liang ),( Cheng-cheng Zhang ),( Zhang-jun Cheng ),( Yong-hai Peng ),( Yao-ming Zhang ),( Zhi-yu Chen ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Iatrogenic biliary injury (IBI) following laparoscopic cholecystectomy (LC) is the most common and recognized iatrogenic complications. Little is known whether LC-IBI would lead to surgeon’s mental distress. This study reports the incidence of surgeon’s mental distress who have caused LC-IBI and risk factors of surgeon’s severe mental distress (SMD). Methods: A cross-sectional survey in the form of electronic questionnaire was conducted among Chinese general surgeons who have caused LC-IBI. The six collected clinical features relating to mental distress included: 1) feeling burnout, anxiety, or depression, 2) avoiding performing LC, 3) having physical reactions when recalling the incidence, 4) having the urge to quit surgery, 5) taking psychiatric medications, and 6) seeking professional psychological counseling. Univariable and multivariable analyses were performed to identify risk factors of SMD, which was defined as meeting ≥3 of the above-mentioned clinical features. Results: Among 1,466 surveyed surgeons, 1,236(84.3%) experienced mental distress following LC-IBI, and nearly half (49.7%, 614/1236) had SMD. Multivariable analyses demonstrated that surgeons from non-university affiliated hospitals (OR:1.873), patients who required multiple repair operations (OR:4.075), patients who required hepaticojejunostomy/partial hepatectomy (OR:1.859), existing lawsuit litigation (OR:10.491), existing violent doctor-patient conflicts (OR:4.995), needing surgeons’ personal compensation (OR:2.531), and additional administrative punishment by hospitals (OR:2.324) were independent risk factors of surgeon’s SMD. Conclusions: Four out of five surgeons experienced mental distress following LC-IBI, and nearly half had SMD. Several independent risk factors of SMD were identified, which could help to make strategies to improve mental well-being of these surgeons.
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