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RISS 인기검색어
- 검색키워드
- 저자 : ( Gooh Yeon Hong ) (검색결과 2 건)
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( Gooh Yeon Hong ),( Kyung Jong Lee ),( Kyeong Man Jeon ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( O Jung Kwon ),( Ho Joong Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Objectives: To investigate the clinical characteristics, management modalities and outcomes in patients with relapsing polychondritis (RP) involving airways. Methods: Medical records of RP patients involving airways were collected at the Samsung Medical Center from August 2004 to December 2011. Clinical manifestations including rheumatologic record, diagnostic tests, treatment modalities and clinical outcomes were retrospectively investigated. Results: Twelve patients (5 women and 7 men) with a median age of 48 yr (IQR, 44-60 yr) were included. All patients had airway involvement including trachea (100%), main bronchi (83%) and larynx (25%). Rheumatologic manifestation were frequent including inflammatory arthritis (50%), auricular chondritis (42%), keratoconjuntivitis(42%), nasal chondritis (42%), saddle nose (25%) and sensorineural hearing loss (17%). All patients were treated with high-dose corticosteroids (1,000 mg per day) for acute exacerbation and maintained with oral prednisolone (5-40 mg per day) with weekly methotrexate (2.5-15 mg per week) during follow up. Among the 12 patients, mechanical ventilation was required in 1 patient. Currently, 9 patients have survived without ventilator support and 8 patients without tracheostomy. Two patients underwent tracheostomy with endobronchial stenting. During follow up (median, 24months [IQR 7-50]), clinical outcome was favorable in 9 patients, but 3 patients died of pneumonia and respiratory failure. Conclusions: High doses of corticosteroids on acute exacerbation followed by maintenance-dose prednisolone with methotrexate could be recommended as a therapeutic option in patients with RP involving airways. Airway intervention is sometimes required in experienced hands.
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( Gooh Yeon Hong ),( Byeong Ho Jeong ),( Hye Yun Park ),( Kyeongman Jeon ),( O Jung Kwon ),( Seung Heon Lee ),( Chang Ki Kim ),( Sung Jae Shin ),( Won Jung Koh ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Objectives: To evaluate the clinical efficacy of a Moxifloxacin (MXF)-containing regimen for the treatment of Mycobacterium avium complex (MAC) lung disease. Patients and Methods: Consecutive patients with MAC lung disease who were diagnosed between January 2002 and December 2011 were identified using the database of the NTM Registry of Samsung Medical Center. We identified 47 patients (32 males and 15 females; median age, 65 yr [IQR 56-70 yr]) who received MXF for ≥4 weeks for the treatment of MAC lung disease. Results: Thirty-two patients (68%) were treated with MXF-containing regimens because of persistent positive culture after at least 6 months of clarithromycin (CLR)-based standardized antibiotic therapy and 15 patients (32%) received MXF as a substitute for ethambutol (EMB) because they discontinued EMB due to side effect such as optic neuritis. The sputum conversion rate after MXF therapy was 34% (11/32) and 27% (4/15), respectively. The overall treatment success rate was 32% (15/47) and sputum culture conversion failed in 32 patients (68%). A positive sputum AFB smear at the start of treatment with MXF containing-regimens was an independent predictor of an unfavorable microbiologic response. Conclusions: MXF-containing antibiotic treatment for MAC lung disease can be effective in some cases. Further research is needed to study the clinical efficacy of a MXF-containing regimen for the treatment of MAC lung disease.
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