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- 저자 : ( Eun Deuck Chang ) (검색결과 1 건)
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( Hiun Suk Chae ),( Hyung Keun Kim ),( Jin Soo Kim ),( Hye Sook Son ),( Yong Wan Park ),( Eun Deuck Chang ),( Hye Kyung Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Signaling pathways via ILK and beta-catenin are important ones in cancer progression and apoptosis of various cancer including colon and stomach. It roles of cancer cell are cell to adhesion, cell migration and motility. In colon cancer, two molecules are highly expressed. So we investigated their expression in colon polyps according to gross morphology and pathologic type. Methods: The expression of ILK and beta-catenin are measured with immunohistochemistry (Santa Cruz Co.) According to morphology, we calssified polyps into pedunculated polyps (Ip, 19), sessile polyps (Is, 31) and laterally spreading tumor (LST, 26). In pathologic type, colon polyps classified into adenocarcinoma (2), tubular adenoma (TA, 47), hyperplastic polyp (HP, 22), tubulovillous polyp (TV, 4), villous type (1). Results: According to morphology, there was no significant difference of ILK and beta-catenin expression among Ip, Is and LST (P>0.05). 2 malignant polyps revealed high expression of ILK and beta-catenin. ILK and beta-catenin expression in tubular adenomatous polyps were significantly higher than hyperplastic polyps (P<0.05). And in tubular adenoma, ILK and beta-catenin were highly expressed in high grade dysplasia (P<0.05). Conclusions: ILK and beta-catenin are not different in gross morphology of colon polyps but more expressed in tubular adenoma, especially in severe dysplasia.
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